Detailed information for compound 1780056

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 433.405 | Formula: C21H21F2N3O5
  • H donors: 2 H acceptors: 4 LogP: 3.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC([C@H]1CO[C@H]2N1C(=O)c1n(C2)cc(c(=O)c1O)C(=O)NCc1ccc(cc1F)F)C
  • InChi: 1S/C21H21F2N3O5/c1-10(2)15-9-31-16-8-25-7-13(18(27)19(28)17(25)21(30)26(15)16)20(29)24-6-11-3-4-12(22)5-14(11)23/h3-5,7,10,15-16,28H,6,8-9H2,1-2H3,(H,24,29)/t15-,16-/m1/s1
  • InChiKey: UYGDHZSXXCJDHX-HZPDHXFCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0087 0.0094
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0002 0.0002
Schistosoma mansoni microtubule-associated protein tau 0.0755 0.2618 0.2821
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0186 0.0185
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0018
Entamoeba histolytica casein kinase, putative 0.0276 0.0946 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0477 0.0514
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0117 0.0116
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0047 0.0046
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0073 0.0238 0.0207
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0268 0.0917 0.1934
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0017 0.0018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0087 0.0094
Loa Loa (eye worm) hypothetical protein 0.0094 0.031 0.0334
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0018
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0224 0.0192
Trypanosoma cruzi aminopeptidase, putative 0.0094 0.031 0.0308
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0018
Entamoeba histolytica aminopeptidase, putative 0.0268 0.0917 0.9688
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0113 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0017
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0017 0.0018
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0064 0.0133
Brugia malayi thymidylate synthase 0.2663 0.9279 1
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0008 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0073 0.0238 0.0256
Loa Loa (eye worm) hypothetical protein 0.0098 0.0325 0.035
Trypanosoma cruzi casein kinase II, putative 0.0276 0.0946 0.0944
Onchocerca volvulus 0.0038 0.0113 0.0119
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0094 0.031 0.031
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0083 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Schistosoma mansoni ap endonuclease 0.0019 0.0047 0.0051
Onchocerca volvulus 0.0235 0.0803 0.0863
Mycobacterium tuberculosis Hypothetical protein 0.1362 0.4735 0.5079
Entamoeba histolytica acyl-CoA synthetase, putative 0.0098 0.0325 0.3428
Entamoeba histolytica hypothetical protein 0.001 0.0016 0.0164
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0224 0.0192
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0056 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0113 0.0237
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0268 0.0917 0.0916
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0083 0.0089
Brugia malayi Patched related family protein 12 0.0006 0.0003 0.0003
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0083 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0016 0.0014
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0268 0.0917 0.0988
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.0276 0.0946 0.1996
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0091 0.0098
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0049 0.0503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0018
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0049 0.0052
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0268 0.0917 0.1934
Leishmania major hypothetical protein, conserved 0.0038 0.0113 0.0112
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0029 0.0083 0.0082
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0052 0.0162 0.0175
Echinococcus granulosus dna polymerase kappa 0.0019 0.0049 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0325 0.035
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0268 0.0917 0.0988
Schistosoma mansoni hypothetical protein 0.0076 0.0246 0.0265
Trypanosoma brucei Aminopeptidase M1, putative 0.0268 0.0917 0.0916
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0041 0.0125 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0122
Brugia malayi follicle stimulating hormone receptor 0.0242 0.0827 0.0891
Trypanosoma brucei Casein kinase II 0.0276 0.0946 0.0945
Echinococcus multilocularis snurportin 1 0.031 0.1065 0.1148
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0083 0.0172
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0089
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0083 0.0089
Loa Loa (eye worm) hypothetical protein 0.0067 0.0217 0.0234
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0113 0.0071
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0268 0.0917 0.0916
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0017
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0137 0.0136
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0029 0.0083 0.0086
Schistosoma mansoni hypothetical protein 0.0031 0.0091 0.0098
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0328 0.3464
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0018
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0083 0.0082
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0091 0.0098
Giardia lamblia Replication factor C, subunit 1 0.001 0.0016 0.0148
Schistosoma mansoni hypothetical protein 0.0041 0.0125 0.0135
Echinococcus granulosus nibrin 0.001 0.0016 0.0017
Schistosoma mansoni ran 0.0021 0.0056 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0016 0.0014
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0083 0.0089
Onchocerca volvulus 0.0052 0.0162 0.0172
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0016 0.0017
Brugia malayi Myosin head containing protein 0.0006 0.0003 0.0003
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0328 0.0354
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0268 0.0917 0.0988
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0268 0.0917 0.0988
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0113 0.0122
Plasmodium falciparum casein kinase 2, alpha subunit 0.0276 0.0946 0.0945
Brugia malayi ecdysteroid receptor 0.001 0.0017 0.0018
Onchocerca volvulus 0.0038 0.0113 0.0119
Onchocerca volvulus 0.0094 0.031 0.0332
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0083 0.0038
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0083 0.0038
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0016 0.0017
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0268 0.0917 0.0988
Loa Loa (eye worm) hypothetical protein 0.0094 0.031 0.0334
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0047 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.287 1 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0094 0.031 0.0308
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0091 0.0088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0047 0.0045
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0094 0.031 0.031
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0047 0.0098
Brugia malayi Peptidase family M1 containing protein 0.0818 0.2839 0.3059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0046
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0268 0.0917 0.0914
Toxoplasma gondii aminopeptidase N protein 0.0094 0.031 0.0309
Loa Loa (eye worm) patched family protein 0.0006 0.0003 0.0003
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.2663 0.9279 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.0572
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Onchocerca volvulus 0.2663 0.9279 1
Echinococcus multilocularis expressed conserved protein 0.0093 0.0307 0.0331
Brugia malayi kap beta 3 protein 0.0005 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0076 0.0246 0.2591
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.2663 0.9279 1
Trypanosoma cruzi aminopeptidase, putative 0.0268 0.0917 0.0914
Echinococcus multilocularis casein kinase ii subunit alpha 0.0276 0.0946 0.1019
Echinococcus granulosus importin 5 0.0005 0.0001 0.0001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.0827 0.0891
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0016 0.0033
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0064 0.0062
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0004 0.0007
Toxoplasma gondii aminopeptidase N, putative 0.0094 0.031 0.0309
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.0056
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi DKFZp564C0469 protein 0.001 0.0016 0.0017
Echinococcus multilocularis geminin 0.0164 0.0555 0.0598
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0334 0.0359
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0046
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0064 0.0133
Echinococcus granulosus tumor protein p63 0.0353 0.1215 0.131
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0113 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0018
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0137 0.0134
Loa Loa (eye worm) hypothetical protein 0.003 0.0087 0.0094
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0094 0.031 0.0309
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0091 0.0098
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Mycobacterium ulcerans lipase LipD 0.0038 0.0113 0.0119
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0098 0.0325 0.0348
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Schistosoma mansoni patched 1 0.0043 0.013 0.014
Mycobacterium ulcerans hypothetical protein 0.0038 0.0113 0.0119
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0477 0.0514
Loa Loa (eye worm) hypothetical protein 0.0073 0.0238 0.0256
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.287 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0017
Echinococcus multilocularis protein patched 0.0043 0.013 0.014
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0091 0.009
Loa Loa (eye worm) oxidoreductase 0.0029 0.0083 0.0089
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.0098
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.013 0.014
Echinococcus multilocularis translational activator gcn1 0.0005 0.0001 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0113 0.0237
Echinococcus multilocularis protein dispatched 1 0.0049 0.0151 0.0163
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0094 0.031 0.0309
Loa Loa (eye worm) hypothetical protein 0.0724 0.251 0.2705
Schistosoma mansoni hypothetical protein 0.0041 0.0125 0.0135
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0083 0.0038
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0049 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Loa Loa (eye worm) acetyltransferase 0.0144 0.0483 0.0521
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0016 0.0033
Loa Loa (eye worm) patched family protein 0.0006 0.0003 0.0003
Toxoplasma gondii patched family protein 0.0006 0.0003 0.0002
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0094 0.031 0.0308
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0332 0.114 0.1226
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0049 0.0001
Schistosoma mansoni hypothetical protein 0.0164 0.0555 0.0598
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0016 0.0015
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0056 0.0061
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0098 0.0325 0.0301
Brugia malayi Patched related family protein 4 0.0006 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.0086
Mycobacterium ulcerans aminopeptidase N PepN 0.0268 0.0917 0.0985
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0083 0.0038
Echinococcus multilocularis transportin 1 0.0005 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0018
Brugia malayi polk-prov protein 0.0006 0.0002 0.0002
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0083 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0018
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0083 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0143 0.0154
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0083 0.0089
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Plasmodium falciparum importin beta, putative 0.0029 0.0083 0.0082
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0016 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0004 0.0007
Echinococcus granulosus FTZ F1 alpha 0.001 0.0017 0.0018
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0113 0.0071
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0326 0.0351
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0002 0.0002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.2836 0.3057
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0016 0.0014
Plasmodium vivax acyl-CoA synthetase, putative 0.0073 0.0238 0.0238
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0268 0.0917 0.0916
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0113 0.0112
Schistosoma mansoni importin beta-1 0.0029 0.0083 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0047 0.0051
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0029 0.0083 0.0086
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0083 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0033
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0069 0.0023
Brugia malayi CXXC zinc finger family protein 0.0028 0.0081 0.0087
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.287 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0046
Loa Loa (eye worm) aminopeptidase N 0.0268 0.0917 0.0988
Loa Loa (eye worm) hypothetical protein 0.0073 0.0238 0.0256
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0083 0.0082
Entamoeba histolytica protein kinase domain containing protein 0.0276 0.0946 1
Trichomonas vaginalis CMGC family protein kinase 0.0276 0.0946 0.1996
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0017 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.1362 0.4735 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.0086
Onchocerca volvulus 0.0268 0.0917 0.0985
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.0086
Brugia malayi steroid hormone receptor 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0099 0.0326 0.0351
Loa Loa (eye worm) hypothetical protein 0.0174 0.0588 0.0633
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0017 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0224 0.0192
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0017 0.0018
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0162 0.0175
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0483 0.0521
Onchocerca volvulus 0.0028 0.0081 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0122
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0268 0.0917 0.0988
Loa Loa (eye worm) hypothetical protein 0.0099 0.0328 0.0354
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0018
Entamoeba histolytica Ran family GTPase 0.0021 0.0056 0.0587
Brugia malayi beta-lactamase family protein 0.0038 0.0113 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0028 0.0027
Brugia malayi hypothetical protein 0.0268 0.0917 0.0988
Trichomonas vaginalis CMGC family protein kinase 0.0276 0.0946 0.1996
Plasmodium falciparum lipid/sterol:H+ symporter 0.0006 0.0003 0.0002
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0094 0.031 0.0308
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0017 0.0018
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0029 0.0083 0.0086
Brugia malayi Casein kinase II, alpha chain 0.0276 0.0946 0.1019
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.0086
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0001 0.0001
Onchocerca volvulus 0.0029 0.0083 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0018
Loa Loa (eye worm) thymidylate synthase 0.2663 0.9279 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.001 0.0011
Plasmodium falciparum acyl-CoA synthetase 0.0073 0.0238 0.0237
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0056 0.0056
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0004 0.0007
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0038 0.0113 0.0071
Onchocerca volvulus 0.0038 0.0113 0.0119
Brugia malayi RNA, U transporter 1 0.0083 0.027 0.0291
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Echinococcus multilocularis thymidylate synthase 0.2663 0.9279 1
Brugia malayi hypothetical protein 0.001 0.0016 0.0017
Brugia malayi hypothetical protein 0.1362 0.4735 0.5103
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0073 0.0238 0.1974
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0029 0.0083 0.0086
Trichomonas vaginalis ran, putative 0.0021 0.0056 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0004 0.0007
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0056 0.0054
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0325 0.0324
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.001 0.0011
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0083 0.008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0017 0.0018
Brugia malayi dihydrofolate reductase family protein 0.0332 0.114 0.1228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0004 0.0007
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0094 0.031 0.0334
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.1362 0.4735 0.4734
Plasmodium vivax patched family protein, putative 0.0006 0.0003 0.0003
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0049 0.01
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0083 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0174 0.0588 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.013 0.0274
Loa Loa (eye worm) histone methyltransferase 0.001 0.0016 0.0017
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0094 0.031 0.0654
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0268 0.0917 0.0988
Schistosoma mansoni hypothetical protein 0.0031 0.0091 0.0098
Loa Loa (eye worm) hypothetical protein 0.0044 0.0137 0.0147
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0002 0.0002
Toxoplasma gondii patched family protein 0.0006 0.0003 0.0002
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0083 0.0082
Toxoplasma gondii patched family protein 0.0006 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Toxoplasma gondii ABC1 family protein 0.0038 0.0113 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0018
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0268 0.0917 0.0988
Brugia malayi CHE-14 protein 0.0043 0.013 0.014
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0089
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0129 0.0128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0004 0.0007
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0018
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0117 0.1227
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0083 0.008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0017 0.0018
Schistosoma mansoni nuclear hormone receptor 0.001 0.0017 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0016 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0143 0.0154
Brugia malayi TATA binding protein associated factor 0.0094 0.031 0.0334
Echinococcus granulosus dihydrofolate reductase 0.0332 0.114 0.1228
Schistosoma mansoni hypothetical protein 0.0031 0.0091 0.0098
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0047 0.0045
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0049 0.0052
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0016 0.0033
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0469 0.0505
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0087 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.0086
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0113 0.0104
Mycobacterium ulcerans acetyl-CoA synthetase 0.0029 0.0083 0.0086
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0029 0.0083 0.0086
Schistosoma mansoni ap endonuclease 0.0019 0.0047 0.0051
Echinococcus multilocularis dihydrofolate reductase 0.0332 0.114 0.1228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0087 0.0094
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0268 0.0917 0.0988
Brugia malayi Peptidase family M1 containing protein 0.0268 0.0917 0.0988
Echinococcus multilocularis nibrin 0.001 0.0016 0.0017
Toxoplasma gondii exonuclease III APE 0.0019 0.0047 0.0046
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0113 0.0071
Brugia malayi hypothetical protein 0.0006 0.0003 0.0003
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0083 0.0172
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0049 0.0048
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0016 0.0015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0246 0.0265
Entamoeba histolytica acyl-coA synthetase, putative 0.0098 0.0325 0.3428
Toxoplasma gondii patched family protein 0.0006 0.0003 0.0002
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0483 0.0521
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0029 0.0083 0.0086
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.013 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0073 0.0238 0.0256
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0276 0.0946 0.1019
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0018
Loa Loa (eye worm) TATA binding protein associated factor 0.0094 0.031 0.0334
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0016 0.0017
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0016 0.0015
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0083 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0113 0.0237
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0004 0.0007
Leishmania major casein kinase II, putative 0.0276 0.0946 0.0945
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0017 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0083 0.0089
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Plasmodium vivax SET domain protein, putative 0.003 0.0087 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Echinococcus granulosus Protein patched homolog 1 0.0043 0.013 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0004 0.0007
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0083 0.0082
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0047 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0276 0.0946 0.1996
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0083 0.0089
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Mycobacterium ulcerans thymidylate synthase 0.2663 0.9279 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0047 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Plasmodium vivax unspecified product 0.0276 0.0946 0.0946
Schistosoma mansoni coup transcription factor 0.001 0.0017 0.0018
Leishmania major DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Onchocerca volvulus 0.0818 0.2839 0.3058
Brugia malayi hypothetical protein 0.001 0.0016 0.0017
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0083 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0087 0.0094
Mycobacterium ulcerans hypothetical protein 0.0098 0.0325 0.0348
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0029 0.0083 0.0071
Leishmania major DNA polymerase eta, putative 0.0044 0.0137 0.0136
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0018
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0004 0.0007
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0094 0.031 0.0308
Brugia malayi nuclear receptor NHR-88 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0004 0.0007
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0017 0.0015
Brugia malayi hypothetical protein 0.0094 0.031 0.0334
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0083 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0028 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0018
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0094 0.031 0.0334
Entamoeba histolytica acyl-CoA synthetase, putative 0.0098 0.0325 0.3428
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0008 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0047 0.0098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0004 0.0007
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0094 0.031 0.0334
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0083 0.0086
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0047 1
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0002 0.0002
Brugia malayi hypothetical protein 0.0006 0.0003 0.0003
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0129 0.0271
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0094 0.031 0.0309
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0047 0.0046
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0047 0.0051
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0098 0.0325 0.0333
Loa Loa (eye worm) dihydrofolate reductase 0.0332 0.114 0.1228
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.014
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0083 0.008
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0332 0.114 0.1213
Onchocerca volvulus 0.0029 0.0083 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0002 0.0002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0704 0.0759
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0047 0.0051
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0087 0.0086
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0129 0.0129
Echinococcus multilocularis importin 5 0.0005 0.0001 0.0001
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0064 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0028 0.0027
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0017 0.0018
Brugia malayi hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0018
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.287 1 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0029 0.0083 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0017
Echinococcus multilocularis tumor protein p63 0.0353 0.1215 0.131
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0083 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.0276 0.0946 0.1996
Trypanosoma brucei unspecified product 0.0019 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi Patched protein homolog 1 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0018
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0016 0.0164
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0332 0.114 0.1184
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0326 0.0351
Chlamydia trachomatis dihydrofolate reductase 0.0332 0.114 1
Echinococcus multilocularis dna polymerase eta 0.0044 0.0137 0.0147
Echinococcus granulosus geminin 0.0164 0.0555 0.0598
Echinococcus multilocularis cpg binding protein 0.003 0.0087 0.0093
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0268 0.0917 0.0988
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0083 0.0083
Brugia malayi beta-lactamase 0.0038 0.0113 0.0122
Trichomonas vaginalis esterase, putative 0.0038 0.0113 0.0237
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0113 0.0071
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0551 0.1904 0.2052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0087 0.0094
Brugia malayi protein C24B5.3 0.0006 0.0003 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0326 0.0351
Onchocerca volvulus 0.001 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0098 0.0325 0.035
Echinococcus granulosus expressed conserved protein 0.0093 0.0307 0.0331
Echinococcus granulosus leukotriene A 4 hydrolase 0.0094 0.031 0.0334
Mycobacterium ulcerans aminopeptidase N PepN 0.0094 0.031 0.0332
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0049 0.0048
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0056 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0083 0.0089
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0268 0.0917 0.0988
Brugia malayi Peptidase family M1 containing protein 0.0094 0.031 0.0334
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0325 0.0348
Echinococcus granulosus translational activator gcn1 0.0005 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0083 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0143 0.0154
Loa Loa (eye worm) patched family protein 0.0006 0.0003 0.0003
Onchocerca volvulus 0.0029 0.0083 0.0086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0246 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0018
Loa Loa (eye worm) peptidase family M1 containing protein 0.0645 0.2233 0.2406
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0091 0.0098
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0017 0.0018
Echinococcus granulosus GPCR family 2 0.0031 0.0091 0.0098
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0083 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0325 0.035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0143 0.0154
Loa Loa (eye worm) hypothetical protein 0.0073 0.0238 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0004 0.0007
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0268 0.0917 0.0988
Schistosoma mansoni hypothetical protein 0.0164 0.0555 0.0598
Schistosoma mansoni hypothetical protein 0.0031 0.0091 0.0098
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0122
Leishmania major importin beta-1 subunit, putative 0.0024 0.0064 0.0063
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0117 0.1213
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0325 0.0324
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0004 0.0007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0047 0.049
Toxoplasma gondii hypothetical protein 0.0006 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0033
Loa Loa (eye worm) hypothetical protein 0.0098 0.0325 0.035
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0016 0.0017
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0083 0.0038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0017 0.0018
Schistosoma mansoni ran 0.0021 0.0056 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Brugia malayi Importin beta-1 subunit 0.0029 0.0083 0.0089
Entamoeba histolytica hypothetical protein 0.0076 0.0246 0.2591
Echinococcus multilocularis aminopeptidase N 0.0818 0.2839 0.3059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0018
Brugia malayi Patched related family protein 10 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0217 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0113 0.0122
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0174 0.0588 0.0586
Onchocerca volvulus 0.0098 0.0325 0.0347
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0049 0.0048
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0049 0.0048
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0049 0.0052
Schistosoma mansoni importin-beta 2 0.0005 0.0001 0.0001
Echinococcus granulosus replication factor c subunit 1 0.001 0.0016 0.0017
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0129 0.0128
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0083 0.008
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Echinococcus granulosus aminopeptidase N 0.0818 0.2839 0.3059
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0018
Giardia lamblia DINP protein human, muc B family 0.0019 0.0049 0.0488
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0113 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0094 0.031 0.0334
Plasmodium vivax transportin, putative 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0129 0.0139
Leishmania major GTP-binding protein, putative 0.0021 0.0056 0.0056
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0056 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0113 0.0111
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0094 0.031 0.0334
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0017
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0049 0.01
Echinococcus granulosus casein kinase ii subunit alpha 0.0276 0.0946 0.1019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0113 0.0071
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.0086
Onchocerca volvulus 0.003 0.0087 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0143 0.0154
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0047 0.0475
Echinococcus granulosus microtubule associated protein 2 0.0755 0.2618 0.2821
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0087 0.0094
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0098 0.0325 0.0348
Schistosoma mansoni hypothetical protein 0.0041 0.0125 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0113 0.0237
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0224 0.0192
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0016 0.0015
Mycobacterium tuberculosis Conserved protein 0.0038 0.0113 0.0071
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0017 0.0018
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0049 0.0052
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0056 0.0056
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0174 0.0588 0.0633
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0325 0.035
Echinococcus granulosus importin subunit beta 1 0.0029 0.0083 0.0089
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.2663 0.9279 1
Loa Loa (eye worm) patched family protein 0.0006 0.0003 0.0003
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0048
Brugia malayi Dihydrofolate reductase 0.0332 0.114 0.1228
Leishmania major DNA polymerase eta, putative 0.0031 0.0091 0.009
Leishmania major DNA polymerase kappa, putative 0.0006 0.0002 0.0002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0113 0.0071
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0017 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0004 0.0007
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0049 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.0086
Loa Loa (eye worm) hypothetical protein 0.0052 0.0164 0.0176
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0276 0.0946 0.0946
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0016 0.0017
Onchocerca volvulus 0.0029 0.0083 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0325 0.0348
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0049 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0238 0.0254
Brugia malayi protein C24B5.3 0.0006 0.0003 0.0003
Onchocerca volvulus 0.001 0.0017 0.0015
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0094 0.031 0.0309
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0137 0.0147
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0002 0.0002
Leishmania major DNA damage repair protein, putative 0.0006 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0038 0.0113 0.0071
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0083 0.0863
Schistosoma mansoni DNA ligase IV 0.001 0.0016 0.0017
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0098 0.0325 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0033
Brugia malayi Pre-SET motif family protein 0.0207 0.0704 0.0759
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0091 0.0098
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0081 0.0087
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0129 0.0271
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0083 0.0082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0081 0.0087
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0017
Trypanosoma brucei unspecified product 0.0013 0.0028 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0049 0.005
Schistosoma mansoni cpg binding protein 0.0028 0.0081 0.0087
Trichomonas vaginalis CMGC family protein kinase 0.0276 0.0946 0.1996
Trypanosoma cruzi Aminopeptidase M1, putative 0.0268 0.0917 0.0914
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0821 0.0839
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0029 0.0083 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0143 0.0154
Echinococcus granulosus snurportin 1 0.031 0.1065 0.1148
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.013 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0143 0.0154
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0113 0.0119
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0113 0.0122
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.1065 0.1148
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0018
Schistosoma mansoni cpg binding protein 0.003 0.0087 0.0093
Echinococcus granulosus thymidylate synthase 0.2663 0.9279 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Trypanosoma brucei Aminopeptidase M1, putative 0.0268 0.0917 0.0916
Schistosoma mansoni cpg binding protein 0.003 0.0087 0.0093
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0094 0.031 0.0334
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0098 0.0325 0.0333
Trypanosoma brucei unspecified product 0.0013 0.0028 0.0027
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0049 0.0052
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0091 0.0098
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0083 0.0089
Trypanosoma brucei aminopeptidase, putative 0.0094 0.031 0.0309
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0113 0.0111
Echinococcus granulosus transportin 1 0.0005 0.0001 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0098 0.0325 0.0348
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0246 0.0265
Schistosoma mansoni hypothetical protein 0.031 0.1065 0.1148
Toxoplasma gondii aminopeptidase n, putative 0.0094 0.031 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0018
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.287 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0049 0.0052
Schistosoma mansoni topbp1 0.001 0.0016 0.0017
Brugia malayi beta-lactamase family protein 0.0038 0.0113 0.0122
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0196 0.0211
Plasmodium vivax importin-beta 2, putative 0.0029 0.0083 0.0083
Mycobacterium ulcerans beta-lactamase 0.0038 0.0113 0.0119
Trichomonas vaginalis CMGC family protein kinase 0.0276 0.0946 0.1996
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0047 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0018
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0328 0.0354
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0017 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0004 0.0007
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0016 0.0033
Loa Loa (eye worm) beta-lactamase 0.0038 0.0113 0.0122
Schistosoma mansoni topbp1 0.001 0.0016 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0122
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi hypothetical protein 0.0006 0.0003 0.0003
Giardia lamblia Kinase, CMGC CK2 0.0276 0.0946 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0113 0.0113
Trichomonas vaginalis helicase, putative 0.0006 0.0004 0.0007
Leishmania major pantothenate kinase subunit, putative 0.0008 0.0009 0.0008
Entamoeba histolytica hypothetical protein 0.0024 0.0064 0.0668
Brugia malayi hypothetical protein 0.0076 0.0246 0.0265
Echinococcus multilocularis microtubule associated protein 2 0.0755 0.2618 0.2821
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0174 0.0588 0.0633
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0016 0.0015
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0083 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0325 0.0348
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0083 0.0089
Loa Loa (eye worm) patched family protein 0.0006 0.0003 0.0003
Schistosoma mansoni protein kinase 0.0276 0.0946 0.1019
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0016 0.0033
Schistosoma mansoni hypothetical protein 0.0067 0.0217 0.0234
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0017 0.0018
Echinococcus granulosus cpg binding protein 0.003 0.0087 0.0093
Schistosoma mansoni aminopeptidase A (M01 family) 0.0094 0.031 0.0334
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0047 0.0046
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0113 0.0122
Entamoeba histolytica hypothetical protein 0.0076 0.0246 0.2591
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0018
Entamoeba histolytica hypothetical protein 0.0076 0.0246 0.2591
Brugia malayi topoisomerase 0.001 0.0016 0.0017
Schistosoma mansoni dihydrofolate reductase 0.0332 0.114 0.1228
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0091 0.0098
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Brugia malayi Patched family protein 0.0006 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0033
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0094 0.031 0.0334
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0016 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0017 0.0018
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0002 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0113 0.0237
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0017 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0143 0.0154
Toxoplasma gondii CMGC kinase, CK2 family 0.0276 0.0946 0.0945
Brugia malayi nuclear hormone receptor 0.001 0.0017 0.0018
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0083 0.0082
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0483 0.0521
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0328 0.0354
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0143 0.0154
Mycobacterium leprae Probable lipase LipE 0.0038 0.0113 0.0104
Echinococcus granulosus dna polymerase eta 0.0044 0.0137 0.0147
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0803 0.1695
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0113 0.0122
Brugia malayi Pre-SET motif family protein 0.003 0.0087 0.0094
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0018
Echinococcus multilocularis GPCR, family 2 0.0031 0.0091 0.0098
Schistosoma mansoni DNA polymerase eta 0.0044 0.0137 0.0147
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0083 0.0082
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0083 0.0082
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0098 0.0325 0.0301
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.0061
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0325 0.0324
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0018

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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