Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0323 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0323 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0203 | 0.3366 | 1 |
Onchocerca volvulus | 0.0323 | 1 | 1 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0203 | 0.3366 | 0.2875 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0203 | 0.3366 | 0.2875 |
Loa Loa (eye worm) | thymidylate synthase | 0.0323 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0203 | 0.3366 | 0.3366 |
Chlamydia trachomatis | pyruvate kinase | 0.0203 | 0.3366 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.3366 | 0.3366 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0323 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0203 | 0.3366 | 0.2875 |
Giardia lamblia | Pyruvate kinase | 0.0203 | 0.3366 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0323 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0203 | 0.3366 | 0.3366 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0203 | 0.3366 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0203 | 0.3366 | 0.2875 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0323 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0323 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0203 | 0.3366 | 0.3366 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0141 | 0 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0203 | 0.3366 | 0.2875 |
Echinococcus multilocularis | pyruvate kinase | 0.0203 | 0.3366 | 0.2611 |
Echinococcus multilocularis | pyruvate kinase | 0.0203 | 0.3366 | 0.2611 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.