Detailed information for compound 1780198

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 514.779 | Formula: C33H54O4
  • H donors: 0 H acceptors: 1 LogP: 7.73 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO[C@@H]1C[C@]2(C)C(=CC[C@H]3[C@@]2(C)CC[C@@H]2[C@]3(C)CC[C@@H](C2(C)C)OC)[C@H]2[C@@]1(CCC(C2)(C)C)C(=O)OC
  • InChi: 1S/C33H54O4/c1-28(2)17-18-33(27(34)37-10)22(19-28)21-11-12-24-30(5)15-14-25(35-8)29(3,4)23(30)13-16-31(24,6)32(21,7)20-26(33)36-9/h11,22-26H,12-20H2,1-10H3/t22-,23-,24+,25-,26+,30-,31+,32+,33+/m0/s1
  • InChiKey: KZMXAIQUPWUWGT-NROPBNNYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0243 0.5696 0.7078
Echinococcus multilocularis cpg binding protein 0.0031 0.0554 0.0554
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0241 0.0241
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0185 0.4303 0.5288
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0202 0.0202
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0031 0.0556 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0031 0.0556 0.108
Onchocerca volvulus Peroxidasin homolog 0.0042 0.081 0.7878
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0118 0.2656 0.3214
Echinococcus granulosus p2X purinoceptor 4 0.0199 0.4631 0.4631
Brugia malayi glutathione reductase 0.0339 0.8047 1
Schistosoma mansoni glutamate synthase 0.0031 0.0556 0.0556
Onchocerca volvulus Peroxidasin homolog 0.0042 0.081 0.7878
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.2656 0.3214
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0031 0.0556 0.0556
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0031 0.0556 0.108
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0031 0.0556 1
Plasmodium vivax JmjC domain containing protein 0.0017 0.02 0.0123
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0118 0.2656 0.6078
Schistosoma mansoni P2X receptor subunit 0.0066 0.1391 0.1391
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.02 0.0123
Schistosoma mansoni sulfide quinone reductase 0.0031 0.0556 0.0556
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0031 0.0556 0.0571
Brugia malayi hypothetical protein 0.0243 0.5696 0.7078
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0031 0.0556 0.0571
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0031 0.0556 0.108
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0031 0.0556 0.0691
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0118 0.2656 0.6078
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0672 0.0835
Plasmodium falciparum enoyl-acyl carrier reductase 0.0185 0.4303 0.5288
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0031 0.0556 0.0556
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.2656 0.3214
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.02 0.02
Trypanosoma cruzi NADH dehydrogenase, putative 0.0031 0.0556 0.0571
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0031 0.0556 0.0556
Plasmodium falciparum glutathione reductase 0.0339 0.8047 1
Plasmodium falciparum thioredoxin reductase 0.0118 0.2656 0.3214
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.2775 0.3449
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0031 0.0556 0.108
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1154 0.1324
Mycobacterium ulcerans ferredoxin reductase 0.0031 0.0556 0.108
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.5696 0.5696
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0556 0.0571
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0185 0.4303 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1077 0.1339
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0031 0.0556 0.0571
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.02 0.02
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0031 0.0556 0.0571
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0031 0.0556 1
Brugia malayi MH2 domain containing protein 0.0123 0.2775 0.3449
Onchocerca volvulus 0.0042 0.081 0.7878
Trichomonas vaginalis mercuric reductase, putative 0.0118 0.2656 0.5604
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0031 0.0556 0.0571
Schistosoma mansoni hypothetical protein 0.005 0.1 0.1
Schistosoma mansoni cpg binding protein 0.0031 0.0554 0.0554
Plasmodium falciparum ferrodoxin reductase-like protein 0.0031 0.0556 0.0571
Loa Loa (eye worm) animal heme peroxidase 0.0042 0.081 0.1006
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0031 0.0556 0.0571
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0031 0.0556 0.0556
Chlamydia trachomatis thioredoxin reductase 0.0031 0.0556 0.108
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0031 0.0556 0.108
Trypanosoma cruzi NADH dehydrogenase, putative 0.0031 0.0556 0.0571
Brugia malayi jmjC domain containing protein 0.0017 0.02 0.0248
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0086 0.1897 0.2358
Loa Loa (eye worm) hypothetical protein 0.0017 0.02 0.0248
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.02 0.0248
Brugia malayi Animal haem peroxidase family protein 0.0042 0.081 0.1006
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.2656 0.3214
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1312 0.2879
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0556 0.0571
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0031 0.0556 0.108
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.2656 0.3214
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1312 0.2879
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0118 0.2656 0.6078
Trypanosoma brucei NADH dehydrogenase 0.0031 0.0556 0.0571
Loa Loa (eye worm) programmed cell death 8 0.0031 0.0556 0.0691
Brugia malayi jmjC domain containing protein 0.0062 0.1307 0.1625
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0118 0.2656 0.3214
Schistosoma mansoni jumonji domain containing protein 0.0017 0.02 0.02
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.02 0.0123
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0339 0.8047 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0202 0.0202
Leishmania major hypothetical protein, conserved 0.0031 0.0556 0.0571
Mycobacterium ulcerans NADH dehydrogenase 0.0031 0.0556 0.108
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0556 0.0571
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0118 0.2656 0.3214
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0031 0.0556 0.0571
Echinococcus granulosus GPCR family 2 0.0017 0.0202 0.0202
Brugia malayi Peroxidasin 0.0042 0.081 0.1006
Echinococcus multilocularis glutamate synthase 0.0031 0.0556 0.0556
Plasmodium falciparum thioredoxin reductase 0.0339 0.8047 1
Schistosoma mansoni protein phosphatase 2C 0.0017 0.02 0.02
Schistosoma mansoni hypothetical protein 0.042 1 1
Plasmodium vivax ferrodoxin reductase, putative 0.0031 0.0556 0.0571
Trichomonas vaginalis hypothetical protein 0.0185 0.4303 1
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.02 0.02
Brugia malayi jmjC domain containing protein 0.0017 0.02 0.0248
Trypanosoma cruzi trypanothione reductase, putative 0.0339 0.8047 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1312 0.1312
Plasmodium vivax thioredoxin reductase, putative 0.0339 0.8047 1
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0031 0.0556 0.0571
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0031 0.0556 0.108
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0031 0.0556 0.108
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0118 0.2656 0.3214
Loa Loa (eye worm) animal heme peroxidase 0.0042 0.081 0.1006
Loa Loa (eye worm) hypothetical protein 0.0017 0.02 0.0248
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0031 0.0556 0.0571
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0118 0.2656 0.3214
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0513 0.0638
Echinococcus granulosus p2X purinoceptor 4 0.0199 0.4631 0.4631
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1312 0.1312
Loa Loa (eye worm) hypothetical protein 0.0017 0.0202 0.0251
Echinococcus multilocularis peroxidasin 0.0042 0.081 0.081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.2656 0.3214
Mycobacterium ulcerans monoxygenase 0.0031 0.0556 0.108
Toxoplasma gondii selenide, water dikinase 0.0031 0.0556 0.0571
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.2656 0.3214
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0016 0.002
Leishmania major trypanothione reductase 0.0339 0.8047 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0102 0.0127
Schistosoma mansoni dihydropteridine reductase 0.0013 0.0102 0.0102
Loa Loa (eye worm) oxidoreductase 0.0013 0.0102 0.0127
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.02 0.0123
Schistosoma mansoni phd/f-box containing protein 0.0017 0.02 0.02
Echinococcus multilocularis thioredoxin glutathione reductase 0.0339 0.8047 0.8047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.2656 0.3214
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0031 0.0556 0.0556
Mycobacterium tuberculosis Probable reductase 0.0031 0.0556 0.0571
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.1348 0.1348
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0031 0.0556 0.0556
Schistosoma mansoni glutamate synthase 0.0031 0.0556 0.0556
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0031 0.0556 0.108
Trypanosoma cruzi trypanothione reductase, putative 0.0118 0.2656 0.3214
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0118 0.2656 0.3214
Loa Loa (eye worm) thioredoxin reductase 0.0339 0.8047 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1312 0.1312
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.02 0.0123
Entamoeba histolytica disulphide oxidoreductase, putative 0.0031 0.0556 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0031 0.0556 0.0556
Schistosoma mansoni hypothetical protein 0.0017 0.0202 0.0202
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.5696 0.5696
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0031 0.0556 0.0571
Echinococcus granulosus cpg binding protein 0.0031 0.0554 0.0554
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0185 0.4303 0.5288
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0031 0.0556 0.108
Schistosoma mansoni P2X receptor subunit 0.0066 0.1391 0.1391
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.1348 0.1348
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0031 0.0556 0.0556
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.02 0.0123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1077 0.1339
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Loa Loa (eye worm) blistered cuticle protein 3 0.0042 0.081 0.1006
Leishmania major NADH dehydrogenase, putative 0.0031 0.0556 0.0571
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0013 0.0102 0.0102
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0031 0.0556 0.0556
Brugia malayi glutamate synthase 0.0031 0.0556 0.0691
Schistosoma mansoni P2X receptor subunit 0.0199 0.4631 0.4631
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0031 0.0556 0.108
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0031 0.0556 0.0571
Entamoeba histolytica thioredoxin reductase, putative 0.0031 0.0556 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0202 0.0251
Echinococcus multilocularis geminin 0.0179 0.4148 0.4148
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0202 0.0251
Schistosoma mansoni peroxidasin 0.0042 0.081 0.081
Echinococcus multilocularis p2X purinoceptor 4 0.0199 0.4631 0.4631
Plasmodium vivax glutathione reductase, putative 0.0339 0.8047 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0031 0.0556 0.0571
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0556 0.0571
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0118 0.2656 0.3214
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.02 0.0123
Schistosoma mansoni hypothetical protein 0.0017 0.0202 0.0202
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.1307 0.1307
Echinococcus granulosus geminin 0.0179 0.4148 0.4148
Onchocerca volvulus 0.0042 0.081 0.7878
Brugia malayi Animal haem peroxidase family protein 0.0042 0.081 0.1006
Trichomonas vaginalis glutathione reductase, putative 0.0118 0.2656 0.5604
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0031 0.0556 0.0571
Onchocerca volvulus Peroxidase homolog 0.0042 0.081 0.7878
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0031 0.0556 0.108
Giardia lamblia NADH oxidase lateral transfer candidate 0.0118 0.2656 1
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0185 0.4303 0.5288
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0031 0.0556 0.0571
Plasmodium falciparum glutathione reductase 0.0118 0.2656 0.3214
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Schistosoma mansoni survival motor neuron protein 0.005 0.1 0.1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0118 0.2656 0.3214
Schistosoma mansoni hypothetical protein 0.0179 0.4148 0.4148
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0556 0.0571
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1 0.1243
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0031 0.0556 0.0571
Mycobacterium ulcerans dehydrogenase 0.0031 0.0556 0.108
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.02 0.02
Mycobacterium tuberculosis Probable dehydrogenase 0.0031 0.0556 0.0571
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.02 0.0248
Onchocerca volvulus Peroxidase homolog 0.0042 0.081 0.7878
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0118 0.2656 0.3214
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0031 0.0556 0.0571
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0031 0.0556 0.0571
Echinococcus multilocularis p2X purinoceptor 4 0.0199 0.4631 0.4631
Echinococcus granulosus phd:f box containing protein 0.0017 0.02 0.02
Leishmania major hypothetical protein, conserved 0.0031 0.0556 0.0571
Loa Loa (eye worm) retinol dehydrogenase 12 0.0013 0.0102 0.0127
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0185 0.4303 1
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0013 0.0102 0.0102
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0086 0.1897 0.2358
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.2656 0.3214
Onchocerca volvulus 0.005 0.1 1
Brugia malayi Animal haem peroxidase family protein 0.0042 0.081 0.1006
Trypanosoma brucei trypanothione reductase 0.0339 0.8047 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1312 0.2879
Schistosoma mansoni hypothetical protein 0.0017 0.0202 0.0202
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.0179 0.4148 0.4148
Schistosoma mansoni P2X receptor subunit 0.0199 0.4631 0.4631
Schistosoma mansoni sulfide quinone reductase 0.0031 0.0556 0.0556
Echinococcus multilocularis p2X purinoceptor 4 0.0199 0.4631 0.4631
Brugia malayi jmjC domain containing protein 0.0017 0.02 0.0248
Echinococcus multilocularis phd:f box containing protein 0.0017 0.02 0.02
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0185 0.4303 1
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0013 0.0102 0.0102
Brugia malayi Thioredoxin reductase 0.0339 0.8047 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Echinococcus granulosus thioredoxin glutathione reductase 0.0339 0.8047 0.8047
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0202 0.0251
Mycobacterium ulcerans glutamate synthase subunit beta 0.0031 0.0556 0.108
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.1307 0.1307
Loa Loa (eye worm) hypothetical protein 0.0053 0.1077 0.1339
Brugia malayi Animal haem peroxidase family protein 0.0042 0.081 0.1006
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0031 0.0556 0.0571
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0118 0.2656 0.2656
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.2656 0.3214
Schistosoma mansoni hypothetical protein 0.0036 0.0672 0.0672
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1312 0.1312
Loa Loa (eye worm) hypothetical protein 0.0013 0.0102 0.0127
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.2775 0.3449
Schistosoma mansoni disulfide oxidoreductase 0.0031 0.0556 0.0556
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0031 0.0556 0.108
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.02 0.0248
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.1307 0.1307
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0118 0.2656 0.3214
Brugia malayi Animal haem peroxidase family protein 0.0042 0.081 0.1006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0672 0.0835
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Schistosoma mansoni glutamate synthase 0.0031 0.0556 0.0556
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0556 0.0571
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0118 0.2656 0.6078
Schistosoma mansoni hypothetical protein 0.0017 0.0202 0.0202
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0031 0.0556 0.0571
Schistosoma mansoni jumonji domain containing protein 0.0062 0.1307 0.1307
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.02 0.02
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1312 0.1522
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.02 0.02
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0031 0.0556 0.0571
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0031 0.0556 0.0691
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0118 0.2656 0.3214
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0019
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.02 0.02
Onchocerca volvulus Chorion peroxidase homolog 0.0042 0.081 0.7878
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.1348 0.1675
Onchocerca volvulus Dual oxidase homolog 0.0042 0.081 0.7878
Echinococcus granulosus glutamate synthase 0.0031 0.0556 0.0556
Leishmania major hypothetical protein, conserved 0.0031 0.0556 0.0571
Onchocerca volvulus 0.0042 0.081 0.7878
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0031 0.0556 0.0691
Loa Loa (eye worm) glutathione reductase 0.0339 0.8047 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0031 0.0556 0.0571
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Onchocerca volvulus 0.0029 0.0513 0.4579
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0118 0.2656 0.3214
Schistosoma mansoni hypothetical protein 0.0031 0.0556 0.0556
Schistosoma mansoni cpg binding protein 0.0029 0.0513 0.0513
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0202 0.0202
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0019
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0118 0.2656 0.3301
Toxoplasma gondii NADPH-glutathione reductase 0.0118 0.2656 0.3214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1077 0.1339
Loa Loa (eye worm) animal heme peroxidase 0.0042 0.081 0.1006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0556 0.0691
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0102 0.0127
Schistosoma mansoni cpg binding protein 0.0031 0.0554 0.0554
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0102 0.0127
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0118 0.2656 0.6078
Mycobacterium ulcerans hypothetical protein 0.0031 0.0556 0.108
Echinococcus multilocularis GPCR, family 2 0.0017 0.0202 0.0202
Brugia malayi hypothetical protein 0.0042 0.081 0.1006
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0556 0.0571
Brugia malayi Blistered cuticle protein 3 0.0042 0.081 0.1006
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0118 0.2656 0.2656
Loa Loa (eye worm) hypothetical protein 0.0017 0.02 0.0248
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0118 0.2656 0.3214
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1312 0.1522
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0031 0.0556 0.0556
Echinococcus multilocularis dnaJ subfamily B 0.042 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1312 0.1522
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0031 0.0556 0.0571
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0031 0.0556 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.2656 0.6078
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0185 0.4303 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.1348 0.1348
Onchocerca volvulus 0.0031 0.0556 0.5052
Brugia malayi CXXC zinc finger family protein 0.0029 0.0513 0.0638
Echinococcus granulosus peroxidasin 0.0042 0.081 0.081
Brugia malayi jmjC domain containing protein 0.0064 0.1348 0.1675
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0031 0.0556 1
Schistosoma mansoni peroxidasin 0.0042 0.081 0.081
Treponema pallidum NADH oxidase 0.0118 0.2656 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.081 0.1006
Toxoplasma gondii thioredoxin reductase 0.0339 0.8047 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0031 0.0556 0.0571
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1317 0.1317
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0031 0.0556 0.108
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0031 0.0556 0.0691
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0118 0.2656 0.3214
Echinococcus granulosus p2X purinoceptor 4 0.0199 0.4631 0.4631
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0031 0.0556 0.0571
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0031 0.0556 0.108
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0118 0.2656 0.6078
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0031 0.0556 0.0556
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0118 0.2656 0.3214
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0031 0.0556 0.0556
Loa Loa (eye worm) animal heme peroxidase 0.0042 0.081 0.1006
Leishmania major hypothetical protein, conserved 0.0017 0.02 0.0123
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0118 0.2656 0.2656
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0118 0.2656 0.3214
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0031 0.0556 0.0571
Brugia malayi jmjC domain containing protein 0.0017 0.02 0.0248
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0031 0.0556 0.0571

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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