TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 602.674 | Formula: C34H38N2O8
H donors: 0 H acceptors: 3 LogP: 5.47 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: O=c1oc(c(o1)COC(=O)C(c1ccc(cc1)CN1CCC(CC1)COC(=O)c1c2OCCCn2c2c1cccc2)(C)C)C
InChi: 1S/C34H38N2O8/c1-22-28(44-33(39)43-22)21-42-32(38)34(2,3)25-11-9-23(10-12-25)19-35-16-13-24(14-17-35)20-41-31(37)29-26-7-4-5-8-27(26)36-15-6-18-40-30(29)36/h4-5,7-12,24H,6,13-21H2,1-3H3
InChiKey: REWWMMNQNRRVCQ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	orexin receptor type 2	0.0012	0.0013	0.0013
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0013	0.0013
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0013	0.0013
Toxoplasma gondii	propionate-CoA ligase	0.0014	0.0022	0.0908
Echinococcus multilocularis	para nitrobenzyl esterase	0.0388	0.1658	0.1657
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0014	0.0022	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0388	0.1658	0.1657
Schistosoma mansoni	opsin-like receptor	0.0012	0.0013	0.0008
Brugia malayi	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus granulosus	somatostatin receptor	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0012	0.0013	0.005
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0012	0.0013	0.0013
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0013	0.0008
Schistosoma mansoni	patched 1	0.0042	0.0147	0.0142
Schistosoma mansoni	neuropeptide f receptor 76f	0.0012	0.0013	0.0008
Echinococcus granulosus	dro:myosuppressin receptor	0.0012	0.0013	0.0013
Echinococcus multilocularis	somatostatin receptor	0.0012	0.0013	0.0013
Treponema pallidum	DNA ligase (lig)	0.001	0.0005	0.5
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0172	0.0167
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0005	0.0004
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.0393	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0013	0.0008
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0361	0.1539	0.1539
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0014	0.0022	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Brugia malayi	hypothetical protein	0.0012	0.0013	0.0013
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0012	0.0013	0.005
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0108	0.0572
Echinococcus multilocularis	protein patched	0.0042	0.0147	0.0146
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0014	0.0022	0.0022
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0005	0.0005
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0117	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus granulosus	hypothetical protein	0.0012	0.0013	0.0013
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0012	0.0013	0.0008
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0014	0.0022	0.0051
Echinococcus multilocularis	carboxylesterase 5A	0.2296	1	1
Onchocerca volvulus		0.0388	0.1658	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.04	0.0395
Onchocerca volvulus		0.0012	0.0013	0.005
Schistosoma mansoni	cpg binding protein	0.003	0.0095	0.009
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0013	0.0008
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0169	0.0169
Brugia malayi	hypothetical protein	0.001	0.0005	0.0005
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0031	0.003
Echinococcus granulosus	dnaJ subfamily B	0.041	0.1754	0.1754
Loa Loa (eye worm)	hypothetical protein	0.0388	0.1658	0.1657
Brugia malayi	Serotonin receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	amine GPCR	0.0012	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0048	0.0172	0.1012
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0012	0.0013	0.0013
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0012	0.0013	0.0008
Echinococcus multilocularis	orexin receptor type 2	0.0012	0.0013	0.0013
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0022	0.0116
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0012	0.0013	0.005
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0172	0.0172
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0169	0.0168
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0014	0.0022	0.0051
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0169	1
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0014	0.0022	0.0107
Brugia malayi	CHE-14 protein	0.0042	0.0147	0.0147
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0031	0.0031
Onchocerca volvulus		0.0388	0.1658	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0005	0.0000062381
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.02	1
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0013	0.0013
Brugia malayi	hypothetical protein	0.001	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0041	0.014	0.0135
Loa Loa (eye worm)	acetylcholinesterase 1	0.2296	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0012	0.0013	0.0008
Brugia malayi	sulfakinin receptor protein	0.0012	0.0013	0.0013
Schistosoma mansoni	hypothetical protein	0.0012	0.0013	0.0008
Echinococcus granulosus	Niemann Pick C1 protein	0.0141	0.0578	0.0578
Loa Loa (eye worm)	oxidoreductase	0.0014	0.0022	0.0022
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0013	0.0013
Echinococcus multilocularis	G protein coupled receptor 139	0.0012	0.0013	0.0013
Echinococcus granulosus	neuropeptide receptor A26	0.0012	0.0013	0.0013
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0013	0.0013
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Brugia malayi	Serotonin receptor	0.0012	0.0013	0.0013
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0022	0.0051
Schistosoma mansoni	opsin-like receptor	0.0012	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0004
Brugia malayi	hypothetical protein	0.0012	0.0013	0.0013
Schistosoma mansoni	hypothetical protein	0.0012	0.0013	0.0008
Brugia malayi	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0013	0.0013
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.0393	0.0393
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0022	0.0107
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0147	0.0146
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0388	0.1658	0.1654
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0013	0.0013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0022	0.0107
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0169	0.0993
Echinococcus granulosus	acetylcholinesterase	0.2296	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0012	0.0013	0.0013
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0012	0.0013	0.0013
Brugia malayi	hypothetical protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Schistosoma mansoni	amine GPCR	0.0012	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0188	0.0188
Schistosoma mansoni	amine GPCR	0.0012	0.0013	0.0008
Mycobacterium ulcerans	carboxylesterase, LipT	0.0388	0.1658	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0013	0.0008
Schistosoma mansoni	opsin-like receptor	0.0012	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0768	0.0767
Schistosoma mansoni	BC026374 protein (S09 family)	0.0388	0.1658	0.1654
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0012	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0012	0.0013	0.0013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Echinococcus granulosus	serotonin receptor	0.0012	0.0013	0.0013
Echinococcus granulosus	BC026374 protein S09 family	0.0388	0.1658	0.1657
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0169	0.4229
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0147	0.0146
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0012	0.0013	0.005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0147	0.0146
Echinococcus multilocularis	acetylcholinesterase	0.2296	1	1
Onchocerca volvulus		0.0014	0.0022	0.0107
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0013	0.0013
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0012	0.0013	0.005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0117	0.0116
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0013	0.0013
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0014	0.0022	0.0022
Onchocerca volvulus		0.0012	0.0013	0.005
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0031	0.003
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0388	0.1658	0.1657
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0147	0.0146
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0388	0.1658	0.1654
Onchocerca volvulus		0.0012	0.0013	0.005
Brugia malayi	larval opioid receptor	0.0012	0.0013	0.0013
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0012	0.0013	0.0013
Echinococcus granulosus	7tm_1 domain containing protein	0.0012	0.0013	0.0013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0022	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0393	0.0393
Brugia malayi	G-protein coupled receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0013	0.0008
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0119	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0169	0.0993
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.018	0.018
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.018	0.018
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.0994	0.0993
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Entamoeba histolytica	hypothetical protein	0.0036	0.0119	0.2949
Brugia malayi	GnHR receptor homolog	0.0012	0.0013	0.0013
Schistosoma mansoni	acetyl-CoA synthetase	0.0014	0.0022	0.0018
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.2296	1	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0031	0.0026
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0012	0.0013	0.0013
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0013	0.0013
Echinococcus granulosus	neuropeptide FF receptor 2	0.0012	0.0013	0.0013
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0031	0.0031
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0013	0.0013
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0169	1
Brugia malayi	neuropeptide F receptor	0.0012	0.0013	0.0013
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0012	0.0013	0.0013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0022	0.0107
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0388	0.1658	0.1657
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0014	0.0022	0.108
Echinococcus granulosus	carboxylesterase 5A	0.2296	1	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.0393	0.0393
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0022	0.0107
Schistosoma mansoni	hypothetical protein	0.041	0.1754	0.175
Loa Loa (eye worm)	carboxylesterase	0.2296	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus multilocularis	expressed conserved protein	0.0093	0.0367	0.0366
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0087	0.0087
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0029	0.0087	0.05
Schistosoma mansoni	gliotactin	0.0388	0.1658	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0031	0.003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0169	0.0993
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0005	0.5
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.0994	0.0993
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0012	0.0013	0.0013
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0229	0.0224
Brugia malayi	follicle stimulating hormone receptor	0.0012	0.0013	0.0013
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0014	0.0022	0.0022
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0173	0.0172
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0108	0.0572
Brugia malayi	hypothetical protein	0.0012	0.0013	0.0013
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0022	0.0051
Echinococcus multilocularis	nibrin	0.001	0.0005	0.0004
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0013	0.0013
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0013	0.0013
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0169	0.0993
Onchocerca volvulus		0.0012	0.0013	0.005
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0169	0.0993
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0014	0.0022	0.0116
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0014	0.0022	0.0022
Brugia malayi	Dopamine receptor	0.0012	0.0013	0.0013
Brugia malayi	Melatonin receptor type 1A	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0236	0.0994	0.0993
Schistosoma mansoni	acetylcholinesterase	0.0388	0.1658	0.1654
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0013	0.0008
Onchocerca volvulus		0.0012	0.0013	0.005
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0169	0.4229
Schistosoma mansoni	hypothetical protein	0.0048	0.0172	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0012	0.0013	0.005
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0013	0.0013
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0005	0.00000073702
Echinococcus multilocularis	g-protein coupled receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0013	0.0008
Schistosoma mansoni	hypothetical protein	0.0041	0.014	0.0135
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	histamine h1 receptor	0.0012	0.0013	0.0008
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0012	0.0013	0.0013
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0022	0.0022
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0388	0.1658	0.1654
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0147	0.0859
Loa Loa (eye worm)	TYRA-2 protein	0.0012	0.0013	0.0013
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0022	0.0116
Loa Loa (eye worm)	carboxylesterase	0.0388	0.1658	0.1657
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0013	0.0008
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.0393	0.0393
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0014	0.0022	0.0107
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0014	0.0022	0.108
Brugia malayi	neuropeptide F receptor	0.0012	0.0013	0.0013
Echinococcus granulosus	cpg binding protein	0.003	0.0095	0.0094
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0013	0.0008
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.018	0.018
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0031	0.003
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0108	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0388	0.1658	0.1657
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0014	0.0022	0.0107
Loa Loa (eye worm)	hypothetical protein	0.2296	1	1
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0012	0.0013	0.0013
Echinococcus multilocularis	serotonin receptor	0.0012	0.0013	0.0013
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0169	0.4229
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0013	0.0008
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0014	0.0022	0.0107
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus multilocularis	dnaJ subfamily B	0.041	0.1754	0.1754
Echinococcus granulosus	sex peptide receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0013	0.0008
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0087	0.0087
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0041	0.014	0.0135
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0169	0.0966
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0012	0.0013	0.0013
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0014	0.0022	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0388	0.1658	0.1657
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0013	0.0008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0022	0.0022
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0169	0.0993
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Entamoeba histolytica	hypothetical protein	0.0036	0.0119	0.2949
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0117	0.0116
Onchocerca volvulus		0.0014	0.0022	0.0107
Brugia malayi	hypothetical protein	0.0012	0.0013	0.0013
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0013	0.0008
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0012	0.0013	0.0013
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0119	0.0119
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0013	0.0013
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0361	0.1539	1
Onchocerca volvulus		0.0012	0.0013	0.005
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0014	0.0022	0.0116
Brugia malayi	hypothetical protein	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0012	0.0013	0.005
Echinococcus granulosus	nibrin	0.001	0.0005	0.0004
Schistosoma mansoni	cpg binding protein	0.0029	0.0087	0.0083
Onchocerca volvulus		0.0014	0.0022	0.0107
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0388	0.1658	0.1654
Echinococcus granulosus	acetylcholinesterase	0.2296	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0013	0.0008
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0388	0.1658	1
Echinococcus multilocularis	allatostatin A receptor	0.0012	0.0013	0.0013
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0388	0.1658	0.1657
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0014	0.0022	0.0107
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0012	0.0013	0.0008
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0111	0.0111
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0013	0.0008
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0169	0.0943
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0388	0.1658	1
Onchocerca volvulus		0.0014	0.0022	0.0107
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0388	0.1658	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0022	0.0107
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0014	0.0022	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0031	0.003
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0013	0.0008
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0012	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0169	0.0993
Echinococcus multilocularis	sex peptide receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0117	0.0116
Brugia malayi	RE15519p	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0361	0.1539	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0012	0.0013	0.0013
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0005	0.00000073702
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0388	0.1658	0.1657
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0022
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	amine GPCR	0.0012	0.0013	0.0008
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0014	0.0022	0.0051
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0388	0.1658	0.1657
Echinococcus granulosus	expressed conserved protein	0.0093	0.0367	0.0366
Onchocerca volvulus		0.0047	0.0169	0.0993
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0117	0.0676
Brugia malayi	AKH receptor	0.0012	0.0013	0.0013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0022	0.0107
Onchocerca volvulus		0.0012	0.0013	0.005
Echinococcus granulosus	neuropeptide s receptor	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0012	0.0013	0.005
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0005	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0012	0.0013	0.0013
Schistosoma mansoni	cpg binding protein	0.003	0.0095	0.009
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0108	0.0572
Loa Loa (eye worm)	hypothetical protein	0.2296	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0013	0.0008
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0169	0.0966
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0012	0.0013	0.005
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0013	0.0013
Echinococcus multilocularis	cpg binding protein	0.003	0.0095	0.0094
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0005	0.00000012189
Brugia malayi	Carboxylesterase family protein	0.0388	0.1658	0.1658
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0014	0.0022	0.1587
Brugia malayi	G protein-coupled receptor F59B2.13	0.0012	0.0013	0.0013
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0012	0.0013	0.0008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0013	0.0013
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0388	0.1658	0.1657
Brugia malayi	hypothetical protein	0.0012	0.0013	0.0013
Entamoeba histolytica	hypothetical protein	0.0036	0.0119	0.2949
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0813	0.3515	0.3515
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0169	0.0169
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0012	0.0013	0.0013
Echinococcus granulosus	fmrfamide receptor	0.0012	0.0013	0.0013
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0014	0.0022	0.0051
Leishmania major	C-8 sterol isomerase-like protein	0.0361	0.1539	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0013	0.0008
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0022	0.0051
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0022
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0117	1
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0014	0.0022	0.1587
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0013	0.0008
Echinococcus multilocularis	serotonin receptor	0.0012	0.0013	0.0013
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0022	0.0116
Onchocerca volvulus		0.0388	0.1658	1
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0014	0.0022	0.108
Echinococcus granulosus	g-protein coupled receptor	0.0012	0.0013	0.0013
Brugia malayi	putative neuropeptide receptor NPR1	0.0012	0.0013	0.0013
Brugia malayi	G-protein coupled receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Brugia malayi	hypothetical protein	0.0036	0.0119	0.0119
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0013	0.0013
Brugia malayi	Carboxylesterase family protein	0.0388	0.1658	0.1658
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Entamoeba histolytica	hypothetical protein	0.0036	0.0119	0.2949
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0169	0.0943
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0022	0.0107
Loa Loa (eye worm)	melatonin receptor type 1A	0.0012	0.0013	0.0013
Brugia malayi	topoisomerase	0.001	0.0005	0.0005
Onchocerca volvulus		0.0012	0.0013	0.005
Brugia malayi	hypothetical protein	0.0236	0.0994	0.0994
Echinococcus multilocularis	neuropeptide s receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0004
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0013	0.0013
Schistosoma mansoni	hypothetical protein	0.0016	0.0031	0.0026
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0005	0.00000073702
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0012	0.0013	0.005
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0147	0.0146
Schistosoma mansoni	hypothetical protein	0.0036	0.0119	0.0115
Echinococcus granulosus	neuroligin	0.0388	0.1658	0.1657
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0013	0.0008
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0012	0.0013	0.0008
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.005	0.018	0.018
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0013	0.0008
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0022	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0169	0.0168
Schistosoma mansoni	hypothetical protein	0.0041	0.014	0.0135
Brugia malayi	Carboxylesterase family protein	0.0388	0.1658	0.1658
Trichomonas vaginalis	spcc417.12 protein, putative	0.0388	0.1658	1
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0119	0.0115
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0012	0.0013	0.0008
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0014	0.0022	0.0107
Echinococcus multilocularis	Niemann Pick C1 protein	0.0141	0.0578	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0022	0.0107
Schistosoma mansoni	hypothetical protein	0.0016	0.0031	0.0026
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0014	0.0022	0.0107
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0022	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0117	0.0116
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0014	0.0022	0.0051
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0013	0.0013
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0388	0.1658	1
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0014	0.0022	0.0457
Brugia malayi	hypothetical protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0014	0.0022	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Schistosoma mansoni	hypothetical protein	0.0034	0.0111	0.0106
Echinococcus granulosus	G protein coupled receptor 139	0.0012	0.0013	0.0013
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0169	0.0169
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0169	0.0966
Schistosoma mansoni	hypothetical protein	0.0016	0.0031	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0012	0.0013	0.0013
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0031	0.003
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0004
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0117	1
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0014	0.0022	0.0107
Echinococcus granulosus	allatostatin A receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0005	0.0004
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0169	0.0993
Onchocerca volvulus		0.0012	0.0013	0.005
Brugia malayi	Dopamine receptor protein 1	0.0012	0.0013	0.0013
Echinococcus granulosus	para nitrobenzyl esterase	0.0388	0.1658	0.1657
Schistosoma mansoni	amine GPCR	0.0012	0.0013	0.0008
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0388	0.1658	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0117	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0013	0.0008
Echinococcus multilocularis	acetylcholinesterase	0.2296	1	1
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0005	0.0000031374
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0005	0.0005
Loa Loa (eye worm)	carboxylesterase	0.0388	0.1658	0.1657
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0013	0.0013
Brugia malayi	hypothetical protein	0.0388	0.1658	0.1658
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0012	0.0013	0.0013
Schistosoma mansoni	myosin xvIII	0.0012	0.0013	0.0008
Schistosoma mansoni	adenoreceptor	0.0012	0.0013	0.0008
Brugia malayi	Carboxylesterase family protein	0.0388	0.1658	0.1658
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0012	0.0013	0.0008
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0013	0.0013
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0031	0.003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0004
Brugia malayi	DKFZp564C0469 protein	0.001	0.0005	0.0005
Brugia malayi	Carboxylesterase family protein	0.2296	1	1
Brugia malayi	G protein-coupled receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0361	0.1539	0.1539
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0013	0.0013
Brugia malayi	Dopamine receptor protein 2	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0013	0.0008
Brugia malayi	putative neuropeptide receptor	0.0012	0.0013	0.0013
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0013	0.0013
Onchocerca volvulus		0.0388	0.1658	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0013	0.0013
Echinococcus multilocularis	neuroligin	0.0388	0.1658	0.1657
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0004
Echinococcus granulosus	GPCR family 2	0.0016	0.0031	0.003
Brugia malayi	ORL1-like opioid receptor	0.0012	0.0013	0.0013
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0014	0.0022	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Schistosoma mansoni	hypothetical protein	0.0012	0.0013	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0111	0.011

Activities

Activity type	Activity value	Assay description	Source	Reference
pKb (binding)		Antagonist activity at human 5-HT4B receptor expressed in HEK293 cells assessed as inhibition of 5-HT-stimulated adenylyl cyclase activity after 20 mins	ChEMBL.	23711770
pKi (binding)		Displacement of [3H]GR113808 from human 5-HT4B receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysis	ChEMBL.	23711770

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2391995

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1780223