Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 9 | Starlite/ChEMBL | References |
Homo sapiens | nicotinamide phosphoribosyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 490 aa | 441 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0522 | 1 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0202 | 0.2809 | 0.3589 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.0418 | 0.7663 | 0.9777 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.0418 | 0.7663 | 0.9777 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0202 | 0.2809 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0097 | 0.0427 | 0.0546 |
Brugia malayi | Pre-B cell enhancing factor precursor | 0.0418 | 0.7663 | 0.9777 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0522 | 1 | 1 |
Onchocerca volvulus | 0.0425 | 0.7828 | 0.5 | |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0418 | 0.7663 | 0.9789 |
Echinococcus granulosus | thymidylate synthase | 0.0425 | 0.7828 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0425 | 0.7828 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0522 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0425 | 0.7828 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0522 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0202 | 0.2809 | 0.2809 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0 | 0.5 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.0418 | 0.7663 | 0.9777 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0425 | 0.7828 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0097 | 0.0427 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0097 | 0.0427 | 0.0546 |
Brugia malayi | thymidylate synthase | 0.0425 | 0.7828 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0425 | 0.7828 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0425 | 0.7828 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0522 | 1 | 1 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.0078 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0425 | 0.7828 | 1 |
Brugia malayi | hypothetical protein | 0.0202 | 0.2809 | 0.3218 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1400 nM | Inhibition of NAMPT (unknown origin) assessed as NAM conversion to NMN preincubated for 15 mins prior to substrate addition measured after 30 mins by mass spectrophotometric analysis | ChEMBL. | 23668988 |
IC50 (functional) | > 2000 nM | Antiproliferative activity against human A2780 cells after 72 hrs by sulforhodamine B assay | ChEMBL. | 23668988 |
IC50 (ADMET) | > 10000 nM | Inhibition of CYP2C9 in human liver microsomes after 30 mins | ChEMBL. | 23668988 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23668988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.