Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0408 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0408 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0408 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0408 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0408 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0408 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0408 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0408 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.4747 | 0.4377 |
Echinococcus granulosus | acetylcholinesterase | 0.0408 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0408 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 150 uM | Inhibition of mouse recombinant N-terminal GST-tagged TTLL7-mediated Ac-DATAEEEGEFEEEAEEEVA glutamylation expressed in Escherichia coli Rosetta2 DE3 after 16 hrs by LC-MS analysis | ChEMBL. | 23777780 |
Inhibition (binding) | Inhibition of TTL (unknown origin) | ChEMBL. | 23777780 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.