Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.046 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.046 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0228 | 0.3261 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.046 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0228 | 0.3261 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.046 | 1 | 1 |
Onchocerca volvulus | 0.046 | 1 | 1 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0228 | 0.3261 | 1 |
Giardia lamblia | Kinase, PLK | 0.0228 | 0.3261 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.046 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0228 | 0.3261 | 0.0386 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.046 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.046 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0228 | 0.3261 | 0.0386 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0228 | 0.3261 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.046 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0228 | 0.3261 | 0.0386 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.046 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.046 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0228 | 0.3261 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.046 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0228 | 0.3261 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0228 | 0.3261 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.046 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0228 | 0.3261 | 0.3261 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.046 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0228 | 0.3261 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.021 uM | Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay | ChEMBL. | 23522834 |
IC50 (binding) | = 0.48 uM | Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay | ChEMBL. | 23522834 |
Stabilty (ADMET) | = 27 % | Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins | ChEMBL. | 23522834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.