Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Golgi-associated plant pathogenesis-related protein 1 homolog | Metabotropic glutamate receptor 3 | 879 aa | 827 aa | 35.9 % |
Onchocerca volvulus | Cell death abnormality protein 8 homolog | Metabotropic glutamate receptor 3 | 879 aa | 867 aa | 43.3 % |
Onchocerca volvulus | Metabotropic glutamate receptor 3 | 879 aa | 784 aa | 21.6 % | |
Loa Loa (eye worm) | hypothetical protein | Metabotropic glutamate receptor 3 | 879 aa | 782 aa | 21.0 % |
Schistosoma mansoni | metabotropic glutamate receptor | Metabotropic glutamate receptor 3 | 879 aa | 894 aa | 27.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0114 | 0.0684 | 0.1148 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0151 | 0.1262 | 0.1262 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0308 | 0.3739 | 1 |
Brugia malayi | hypothetical protein | 0.0147 | 0.1196 | 0.2631 |
Echinococcus granulosus | thymidylate synthase | 0.0308 | 0.3739 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0114 | 0.0684 | 0.0432 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0358 | 0.453 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0176 | 0.1658 | 0.4434 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.013 | 0.0942 | 0.1896 |
Onchocerca volvulus | 0.0308 | 0.3739 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0358 | 0.453 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0308 | 0.3739 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0358 | 0.453 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0308 | 0.3739 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0358 | 0.453 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0276 | 0.3227 | 0.7985 |
Brugia malayi | thymidylate synthase | 0.0308 | 0.3739 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.3739 | 0.3739 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0147 | 0.1196 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0308 | 0.3739 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0308 | 0.3739 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0358 | 0.453 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1658 | 0.3482 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0176 | 0.1658 | 0.4434 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0358 | 0.453 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | Negative allosteric modulation of rat mGlu3 receptor transfected in human TREX cells assessed as inhibition of glutamate-induced calcium mobilization after 2.5 mins | ChEMBL. | 23718281 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.