Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.015 | 0.0097 | 0.1446 |
Giardia lamblia | Vacuolar ATP synthase catalytic subunit A | 0.015 | 0.0097 | 1 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0553 | 0.0455 | 0.6779 |
Plasmodium falciparum | V-type proton ATPase catalytic subunit A | 0.015 | 0.0097 | 0.1762 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit beta | 0.0256 | 0.0192 | 0.0172 |
Trichomonas vaginalis | ATP synthase beta subunit, putative | 0.015 | 0.0097 | 1 |
Brugia malayi | ATP synthase gamma chain, mitochondrial precursor, putative | 0.0373 | 0.0295 | 0.6315 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit delta | 0.236 | 0.2062 | 0.2061 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.132 | 0.1137 | 0.1128 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit B | 0.2272 | 0.1983 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.132 | 0.1137 | 0.1119 |
Trypanosoma cruzi | ATP synthase F1, alpha subunit, putative | 0.0064 | 0.0021 | 0.001 |
Plasmodium vivax | ATP synthase subunit gamma, mitochondrial, putative | 0.0373 | 0.0295 | 0.6315 |
Treponema pallidum | flagellum-specific ATP synthase (fliI) | 0.0256 | 0.0192 | 1 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0796 | 0.0672 | 1 |
Leishmania major | ATP synthase, epsilon chain, putative | 0.0468 | 0.038 | 0.9214 |
Plasmodium falciparum | ATP synthase subunit O, mitochondrial, putative | 0.0088 | 0.0042 | 0.0504 |
Plasmodium vivax | ATP synthase subunit beta, mitochondrial, putative | 0.0256 | 0.0192 | 0.3933 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0373 | 0.0295 | 0.4394 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0373 | 0.0295 | 0.4394 |
Treponema pallidum | V-type ATP synthase subunit B | 0.015 | 0.0097 | 0.4479 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0088 | 0.0042 | 0.0562 |
Onchocerca volvulus | ATP synthase subunit delta, mitochondrial homolog | 0.0468 | 0.038 | 0.5284 |
Trypanosoma brucei | Vacuolar proton pump subunit B, putative | 0.015 | 0.0097 | 0.1965 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0553 | 0.0455 | 0.2214 |
Leishmania major | vacuolar ATP synthase catalytic subunit A, putative | 0.015 | 0.0097 | 0.1965 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0553 | 0.0455 | 1 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.015 | 0.0097 | 0.1965 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-2 | 0.0502 | 0.041 | 1 |
Echinococcus granulosus | mitochondrial ATP synthase subunit 9 | 0.0502 | 0.041 | 0.8967 |
Schistosoma mansoni | vacuolar ATP synthase proteolipid subunit 1 2 3 | 0.0064 | 0.0021 | 0.0305 |
Trichomonas vaginalis | ATP synthase, putative | 0.015 | 0.0097 | 1 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0553 | 0.0455 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0021 | 0.0011 |
Trypanosoma brucei | hypothetical protein | 0.0439 | 0.0354 | 0.8547 |
Chlamydia trachomatis | type III secretion system ATP synthase | 0.015 | 0.0097 | 0.4479 |
Echinococcus granulosus | H transporting ATP synthase O subunit | 0.0088 | 0.0042 | 0.0504 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0373 | 0.0295 | 0.4394 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.015 | 0.0097 | 0.1762 |
Echinococcus multilocularis | ATP synthase subunit delta, mitochondrial | 0.0468 | 0.038 | 0.8262 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-3 | 0.0502 | 0.041 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE DELTA CHAIN ATPH | 0.236 | 0.2062 | 0.2061 |
Trypanosoma cruzi | ATP synthase, epsilon chain, putative | 0.0468 | 0.038 | 0.9214 |
Schistosoma mansoni | vacuolar ATP synthase proteolipid subunit | 0.0064 | 0.0021 | 0.0305 |
Mycobacterium tuberculosis | Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) | 0.0502 | 0.041 | 0.039 |
Brugia malayi | ATP synthase delta chain, mitochondrial precursor, putative | 0.0468 | 0.038 | 0.8262 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.059 | 0.0489 | 0.0469 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0553 | 0.0455 | 0.0435 |
Trypanosoma brucei | V-type ATPase, A subunit, putative | 0.015 | 0.0097 | 0.1965 |
Loa Loa (eye worm) | vacuolar H ATPase family member | 0.015 | 0.0097 | 0.2132 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0467 | 0.0379 | 0.9198 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.015 | 0.0097 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0553 | 0.0455 | 0.0439 |
Loa Loa (eye worm) | ATP synthase F1 | 0.0088 | 0.0042 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0373 | 0.0295 | 0.7644 |
Echinococcus multilocularis | mitochondrial ATP synthase subunit 9 | 0.0502 | 0.041 | 0.8967 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit epsilon | 0.0468 | 0.038 | 0.0362 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.132 | 0.1137 | 0.569 |
Schistosoma mansoni | ATP synthase delta chain | 0.0088 | 0.0042 | 0.0632 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit B | 1.1202 | 0.9921 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit C | 0.0502 | 0.041 | 0.1985 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit gamma | 0.0373 | 0.0295 | 0.0277 |
Echinococcus multilocularis | ATP synthase gamma subunit | 0.0373 | 0.0295 | 0.6315 |
Mycobacterium tuberculosis | Probable ATP synthase epsilon chain AtpC | 0.0468 | 0.038 | 0.036 |
Echinococcus granulosus | ATP synthase gamma subunit | 0.0373 | 0.0295 | 0.6315 |
Toxoplasma gondii | ATP synthase F1 gamma subunit | 0.0373 | 0.0295 | 0.7043 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0502 | 0.041 | 1 |
Plasmodium falciparum | ATP synthase subunit gamma, mitochondrial | 0.0373 | 0.0295 | 0.6315 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0553 | 0.0455 | 1 |
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.015 | 0.0097 | 0.2132 |
Toxoplasma gondii | ATP synthase, putative | 0.0468 | 0.038 | 0.9214 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0502 | 0.041 | 1 |
Toxoplasma gondii | ATP synthase F0 subunit 9, putative | 0.0502 | 0.041 | 1 |
Leishmania major | ATPase alpha subunit | 0.0467 | 0.0379 | 0.9198 |
Brugia malayi | ATP synthase F1, delta subunit family protein | 0.0088 | 0.0042 | 0.0504 |
Entamoeba histolytica | vacuolar ATP synthase subunit B, putative | 0.0086 | 0.004 | 0.2553 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.059 | 0.0489 | 0.0472 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0373 | 0.0295 | 0.4394 |
Toxoplasma gondii | vacuolar ATP synthase subunit A, putative | 0.015 | 0.0097 | 0.1965 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-1 | 0.0502 | 0.041 | 1 |
Trichomonas vaginalis | ATP synthase, putative | 0.0086 | 0.004 | 0.2553 |
Echinococcus multilocularis | H+ transporting ATP synthase O subunit | 0.0088 | 0.0042 | 0.0504 |
Chlamydia trachomatis | transcription termination factor | 0.0064 | 0.0021 | 0.0024 |
Chlamydia trachomatis | type III secretion system ATPase | 0.0256 | 0.0192 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0468 | 0.038 | 0.8262 |
Plasmodium vivax | ATP synthase lipid-binding protein, mitochondrial precursor, putative | 0.0502 | 0.041 | 0.8967 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit delta | 0.0088 | 0.0042 | 0.011 |
Trypanosoma brucei | mitochondrial ATP synthase delta chain | 0.0468 | 0.038 | 0.9214 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.015 | 0.0097 | 0.1762 |
Plasmodium falciparum | V-type proton ATPase subunit B | 0.015 | 0.0097 | 0.1762 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.132 | 0.1137 | 0.1128 |
Treponema pallidum | transcription termination factor Rho | 0.0064 | 0.0021 | 0.0024 |
Plasmodium vivax | vacuolar ATP synthase subunit b, putative | 0.015 | 0.0097 | 0.1762 |
Chlamydia trachomatis | V-type ATP synthase subunit A | 0.015 | 0.0097 | 0.4479 |
Schistosoma mansoni | ATP synthase lipid-binding protein-like protein | 0.0502 | 0.041 | 0.611 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.015 | 0.0097 | 1 |
Schistosoma mansoni | ATP synthase alpha subunit vacuolar | 0.015 | 0.0097 | 0.1446 |
Echinococcus multilocularis | ATP synthase subunit beta, mitochondrial | 0.0256 | 0.0192 | 0.3933 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) | 0.0502 | 0.041 | 0.0393 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit epsilon | 0.0468 | 0.038 | 0.1829 |
Brugia malayi | vacuolar ATP synthase catalytic subunit A, osteoclast isoform | 0.015 | 0.0097 | 0.1762 |
Toxoplasma gondii | ATP synthase beta subunit ATP-B | 0.0256 | 0.0192 | 0.4386 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit gamma | 0.0373 | 0.0295 | 0.1398 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0373 | 0.0295 | 0.4394 |
Schistosoma mansoni | vacuolar ATP synthase proteolipid subunit 1 2 3 | 0.0064 | 0.0021 | 0.0305 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0553 | 0.0455 | 0.0439 |
Leishmania major | ATPase alpha subunit | 0.0467 | 0.0379 | 0.9198 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0553 | 0.0455 | 1 |
Brugia malayi | vacuolar ATP synthase subunit B | 0.015 | 0.0097 | 0.1762 |
Leishmania major | ATPase subunit 9, putative | 0.0502 | 0.041 | 1 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0502 | 0.041 | 1 |
Plasmodium vivax | ATP synthase delta chain, mitochondrial, putative | 0.0088 | 0.0042 | 0.0504 |
Trypanosoma cruzi | ATP synthase F1 subunit gamma protein, putative | 0.0373 | 0.0295 | 0.7043 |
Trypanosoma brucei | ATP synthase F1 subunit gamma protein, putative | 0.0373 | 0.0295 | 0.7043 |
Echinococcus granulosus | vacuolar H ATPase v1 sector subunit A | 0.015 | 0.0097 | 0.1762 |
Mycobacterium tuberculosis | Probable ATP synthase B chain AtpF | 1.1202 | 0.9921 | 0.9921 |
Loa Loa (eye worm) | ATP synthase subunit beta | 0.017 | 0.0115 | 0.2639 |
Brugia malayi | hypothetical protein | 0.0088 | 0.0042 | 0.0504 |
Leishmania major | hypothetical protein, conserved | 0.0088 | 0.0042 | 0.0562 |
Trypanosoma cruzi | V-type proton ATPase subunit B, putative | 0.015 | 0.0097 | 0.1965 |
Trypanosoma cruzi | ATP synthase subunit beta, mitochondrial, putative | 0.0256 | 0.0192 | 0.4386 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.015 | 0.0097 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG | 0.0373 | 0.0295 | 0.0277 |
Schistosoma mansoni | ATP synthase beta subunit | 0.0256 | 0.0192 | 0.2852 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit beta | 0.0256 | 0.0192 | 0.087 |
Plasmodium falciparum | ATP synthase subunit beta, mitochondrial | 0.0256 | 0.0192 | 0.3933 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.015 | 0.0097 | 0.4479 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0467 | 0.0379 | 0.9198 |
Trypanosoma cruzi | ATP synthase F1 subunit gamma protein, putative | 0.0373 | 0.0295 | 0.7043 |
Leishmania major | ATPase beta subunit, putative | 0.0256 | 0.0192 | 0.4386 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE B CHAIN ATPF | 1.1202 | 0.9921 | 1 |
Plasmodium falciparum | ATP synthase subunit C, putative | 0.0502 | 0.041 | 0.8967 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC | 0.0468 | 0.038 | 0.0362 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.015 | 0.0097 | 0.1965 |
Entamoeba histolytica | V-type ATPase, A subunit, putative | 0.015 | 0.0097 | 1 |
Leishmania major | ATPase subunit 9, putative | 0.0502 | 0.041 | 1 |
Treponema pallidum | V-type ATP synthase subunit B | 0.015 | 0.0097 | 0.4479 |
Mycobacterium tuberculosis | Probable ATP synthase gamma chain AtpG | 0.0373 | 0.0295 | 0.0275 |
Leishmania major | ATP synthase F1 subunit gamma protein, putative | 0.0373 | 0.0295 | 0.7043 |
Schistosoma mansoni | ATP synthase lipid-binding protein-like protein | 0.0502 | 0.041 | 0.611 |
Trypanosoma brucei | ATP synthase subunit beta, mitochondrial | 0.0256 | 0.0192 | 0.4386 |
Leishmania major | ATPase subunit 9, putative | 0.0502 | 0.041 | 1 |
Leishmania major | ATPase beta subunit, putative | 0.0256 | 0.0192 | 0.4386 |
Brugia malayi | ATP synthase lipid-binding protein, mitochondrial precursor | 0.0502 | 0.041 | 0.8967 |
Brugia malayi | ATP synthase beta chain, mitochondrial precursor, putative | 0.0256 | 0.0192 | 0.3933 |
Leishmania major | vacuolar ATP synthase subunit b, putative | 0.015 | 0.0097 | 0.1965 |
Schistosoma mansoni | ATP synthase delta chain mitochondrial | 0.0468 | 0.038 | 0.5654 |
Plasmodium falciparum | ATP synthase subunit delta, mitochondrial, putative | 0.0468 | 0.038 | 0.8262 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0502 | 0.041 | 1 |
Echinococcus multilocularis | vacuolar H+ ATPase v1 sector subunit A | 0.015 | 0.0097 | 0.1762 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0042 | 0.061 |
Treponema pallidum | V-type ATP synthase subunit A | 0.015 | 0.0097 | 0.4479 |
Echinococcus granulosus | ATP synthase subunit beta mitochondrial | 0.0256 | 0.0192 | 0.3933 |
Toxoplasma gondii | vacuolar ATP synthase subunit b, putative | 0.015 | 0.0097 | 0.1965 |
Loa Loa (eye worm) | ATP synthase subunit delta | 0.0468 | 0.038 | 1 |
Treponema pallidum | V-type ATP synthase subunit A | 0.015 | 0.0097 | 0.4479 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0553 | 0.0455 | 1 |
Plasmodium vivax | vacuolar ATP synthase catalytic subunit A, putative | 0.015 | 0.0097 | 0.1762 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit C | 0.0502 | 0.041 | 0.0393 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0502 | 0.041 | 1 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit 5 | 0.0088 | 0.0042 | 0.0562 |
Echinococcus granulosus | 5'partial|ATP synthase subunit delta mitochondrial | 0.0468 | 0.038 | 0.8262 |
Toxoplasma gondii | ATP synthase F1, delta subunit protein | 0.0088 | 0.0042 | 0.0562 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0553 | 0.0455 | 1 |
Trypanosoma cruzi | ATPase beta subunit, putative | 0.0064 | 0.0021 | 0.001 |
Trypanosoma cruzi | Vacuolar proton pump subunit B, putative | 0.015 | 0.0097 | 0.1965 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 50 % | Inhibition of human beta-N-acetyl-D-hexosaminidase-A/B using 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide as substrate at 50 uM incubated for 10 mins prior to substrate addition by spectrofluorometric analysis relative to control | ChEMBL. | 24900704 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.