Detailed information for compound 1780621

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.35 | Formula: C19H22F2NO8P
  • H donors: 3 H acceptors: 4 LogP: 2.4 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@@H](C([C@@H]1O)(F)F)OP(=O)(Oc1cccc2c1cccc2)N[C@H](C(=O)OC)C
  • InChi: 1S/C19H22F2NO8P/c1-11(17(25)27-2)22-31(26,30-18-19(20,21)16(24)15(10-23)28-18)29-14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11,15-16,18,23-24H,10H2,1-2H3,(H,22,26)/t11-,15+,16+,18+,31?/m0/s1
  • InChiKey: RXGRWLDVWJKIHZ-GQEDHWAVSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.005 0.0993 0.0968
Toxoplasma gondii thioredoxin reductase 0.0339 1 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0031 0.0422 0.0559
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.3107 0.292
Loa Loa (eye worm) hypothetical protein 0.005 0.0993 0.0993
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0076 0.1804 0.5148
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0023 0.0181 0.0181
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0117 0.3107 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0117 0.3107 0.3088
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0422 0.0559
Toxoplasma gondii selenide, water dikinase 0.0031 0.0422 0.0422
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0076 0.1804 0.1781
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0807 0.1433
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0076 0.1804 0.1804
Loa Loa (eye worm) hypothetical protein 0.0031 0.0422 0.0422
Leishmania major hypothetical protein, conserved 0.0031 0.0422 0.0422
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.005 0.0993 0.2567
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0076 0.1804 0.1763
Brugia malayi phospholipase C homolog 0.0029 0.0359 0.0359
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.3107 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.3107 0.292
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0031 0.0422 0.0422
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0076 0.1804 0.5148
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0023 0.0181 0.0181
Leishmania major hypothetical protein, conserved 0.0031 0.0422 0.0422
Schistosoma mansoni glutamate synthase 0.0031 0.0422 0.0373
Schistosoma mansoni sulfide quinone reductase 0.0031 0.0422 0.0373
Schistosoma mansoni CREB-binding protein 2 0.0117 0.309 0.3055
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0086 0.2137 0.2137
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0026 0.0263 0.0263
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0023 0.0181 0.0181
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.005 0.0993 0.0968
Trypanosoma brucei trypanothione reductase 0.0339 1 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0031 0.0422 0.0373
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0031 0.0422 0.0373
Loa Loa (eye worm) hypothetical protein 0.0052 0.1072 0.1072
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0031 0.0422 0.0395
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0076 0.1804 0.1763
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0031 0.0422 0.0422
Schistosoma mansoni glutamate synthase 0.0031 0.0422 0.0373
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0076 0.1804 0.1804
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0076 0.1804 0.1804
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.005 0.0992 0.2122
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0031 0.0422 0.0395
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0052 0.1072 0.1047
Schistosoma mansoni lipoxygenase 0.008 0.1955 0.1914
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0031 0.0422 0.0395
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0051 0.0022
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0992 0.0992
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0117 0.3107 0.3107
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0049 0.097 0.0924
Echinococcus granulosus thioredoxin glutathione reductase 0.0339 1 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0076 0.1804 0.1804
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0117 0.3107 0.3107
Echinococcus multilocularis glutamate synthase 0.0031 0.0422 0.0395
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0117 0.3107 0.292
Brugia malayi Doublecortin family protein 0.0019 0.0051 0.0051
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0076 0.1804 0.1804
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0117 0.3107 0.3107
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0051 0.0022
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0039 0.0658 0.0658
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0031 0.0422 0.0162
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0052 0.1076 0.1076
Plasmodium falciparum thioredoxin reductase 0.0117 0.3107 0.3072
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0076 0.1804 0.1804
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0076 0.1804 0.1763
Schistosoma mansoni hypothetical protein 0.0031 0.0422 0.0373
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0076 0.1804 0.5148
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0031 0.0422 0.0395
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0117 0.3107 1
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0117 0.309 0.3055
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0023 0.0181 0.0181
Trichomonas vaginalis mercuric reductase, putative 0.0117 0.3107 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0031 0.0422 0.0422
Echinococcus granulosus CREB binding protein 0.0074 0.1743 0.172
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.004 0.0689 0.0663
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0076 0.1804 0.1804
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0164 0.454 0.4512
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0117 0.3107 0.3072
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0339 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0992 0.0966
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0051 0.0022
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.005 0.0993 0.0993
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0031 0.0422 0.0373
Plasmodium falciparum glutathione reductase 0.0117 0.3107 0.3072
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0023 0.0181 0.0181
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0076 0.1804 0.1763
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0031 0.0422 0.0422
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0031 0.0422 0.0395
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0052 0.1072 0.1027
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0117 0.3107 0.3107
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0076 0.1804 1
Trichomonas vaginalis glutamate synthase, putative 0.0031 0.0422 0.0559
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0807 0.076
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0076 0.1804 0.1804
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0992 0.2561
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0031 0.0422 0.0162
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0422 0.0559
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0117 0.3107 0.3072
Echinococcus granulosus CREB binding protein 0.0117 0.309 0.307
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0031 0.0422 0.0422
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0117 0.3107 0.3107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0051
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0992 0.0992
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0117 0.3107 0.3107
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0807 0.2783
Treponema pallidum NADH oxidase 0.0117 0.3107 1
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0052 0.1072 0.1047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0117 0.3107 0.3107
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0076 0.1804 0.5419
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.005 0.0992 0.0992
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0031 0.0422 0.0555
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0422 0.0559
Brugia malayi Thioredoxin reductase 0.0339 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0117 0.3107 1
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.005 0.0992 0.0992
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0076 0.1804 0.1804
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0031 0.0422 0.0422
Giardia lamblia NADH oxidase lateral transfer candidate 0.0117 0.3107 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0117 0.3107 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0117 0.3107 0.3107
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0076 0.1804 0.1781
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0031 0.0422 0.0422
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0076 0.1804 0.1804
Loa Loa (eye worm) hypothetical protein 0.004 0.0689 0.0689
Brugia malayi ThiF family protein 0.0052 0.1072 0.1072
Plasmodium vivax thioredoxin reductase, putative 0.0339 1 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0031 0.0422 0.0422
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0031 0.0422 0.0422
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0031 0.0422 0.0395
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0031 0.0422 0.0162
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0052 0.1076 0.1076
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0031 0.0422 0.0162
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0117 0.3107 0.3107
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.004 0.0689 0.0663
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0076 0.1804 0.5419
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0031 0.0422 0.0395
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0992 0.0946
Trypanosoma cruzi NADH dehydrogenase, putative 0.0031 0.0422 0.0422
Echinococcus granulosus RUN 0.0019 0.0051 0.0022
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.4337 0.4321
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0117 0.3107 0.3072
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0031 0.0422 0.0395
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0117 0.3107 0.3088
Echinococcus granulosus glutamate synthase 0.0031 0.0422 0.0395
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0031 0.0422 0.0395
Leishmania major trypanothione reductase 0.0339 1 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0076 0.1804 0.1804
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0031 0.0422 0.0422
Leishmania major hypothetical protein, conserved 0.0031 0.0422 0.0422
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0117 0.3107 0.3107
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0422 0.0422
Trypanosoma cruzi trypanothione reductase, putative 0.0117 0.3107 0.3107
Trichomonas vaginalis glutamate synthase, putative 0.0031 0.0422 0.0559
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0031 0.0422 0.0395
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0031 0.0422 0.0162
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0076 0.1804 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0031 0.0422 0.0422
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0023 0.0181 0.0181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0117 0.3107 0.3107
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0076 0.1804 0.5148
Loa Loa (eye worm) hypothetical protein 0.0053 0.1102 0.1102
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.005 0.0992 0.0992
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.005 0.0993 0.0993
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0051 0.0022
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0076 0.1804 0.1804
Brugia malayi acetyltransferase, GNAT family protein 0.0164 0.454 0.454
Trypanosoma brucei NADH dehydrogenase 0.0031 0.0422 0.0422
Schistosoma mansoni lipoxygenase 0.0115 0.3033 0.2998
Loa Loa (eye worm) programmed cell death 8 0.0031 0.0422 0.0422
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.005 0.0992 0.0992
Echinococcus multilocularis thioredoxin glutathione reductase 0.0339 1 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0031 0.0422 0.0162
Plasmodium falciparum thioredoxin reductase 0.0339 1 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0031 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.004 0.0689 0.0689
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0117 0.3107 0.3072
Plasmodium vivax glutathione reductase, putative 0.0339 1 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0031 0.0422 0.0422
Trichomonas vaginalis glutathione reductase, putative 0.0117 0.3107 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0031 0.0422 0.0162
Trypanosoma cruzi trypanothione reductase, putative 0.0339 1 1
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0031 0.0422 0.0555
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0051 0.0022
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0076 0.1804 0.1804
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0117 0.3107 0.3107
Plasmodium falciparum glutathione reductase 0.0339 1 1
Onchocerca volvulus 0.0031 0.0422 0.5819
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0117 0.3107 0.3107
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0076 0.1804 0.1804
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0422 0.0422
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.3033 0.3013
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0031 0.0422 0.0373
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0992 0.2561
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.3033 0.3013
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0076 0.1804 0.5419
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0086 0.2137 0.2137
Onchocerca volvulus 0.004 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0051
Onchocerca volvulus 0.004 0.0689 1
Brugia malayi hypothetical protein 0.0019 0.0051 0.0051
Schistosoma mansoni phospholipase C beta 0.0039 0.0658 0.0611
Trichomonas vaginalis apoptosis inducing factor, putative 0.0031 0.0422 0.0559
Schistosoma mansoni glutamate synthase 0.0031 0.0422 0.0373
Schistosoma mansoni disulfide oxidoreductase 0.0031 0.0422 0.0373
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0031 0.0422 0.0555
Loa Loa (eye worm) thioredoxin reductase 0.0339 1 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0076 0.1804 0.1781
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0076 0.1804 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.005 0.0993 0.2567
Leishmania major NADH dehydrogenase, putative 0.0031 0.0422 0.0422
Echinococcus multilocularis CREB binding protein 0.0081 0.1986 0.1963
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0031 0.0422 0.0422
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0031 0.0422 0.0422
Mycobacterium tuberculosis Probable reductase 0.0031 0.0422 0.0162
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0031 0.0422 0.0559
Plasmodium vivax ubiquitin activating enzyme, putative 0.0052 0.1072 0.1027
Loa Loa (eye worm) CBP-B 0.0082 0.2016 0.2016
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0076 0.1804 0.1804
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0076 0.1804 0.1781
Brugia malayi hypothetical protein 0.0019 0.0051 0.0051
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0422 0.0422
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0422 0.0422
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0076 0.1804 0.1763
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0076 0.1804 0.5419
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0422 0.0559
Plasmodium vivax ferrodoxin reductase, putative 0.0031 0.0422 0.0373
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0117 0.3107 0.3107
Toxoplasma gondii NADPH-glutathione reductase 0.0117 0.3107 0.3107
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0422 0.0559
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0031 0.0422 0.0162
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0117 0.3107 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0422 0.0422
Mycobacterium tuberculosis Probable dehydrogenase 0.0031 0.0422 0.0162
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0031 0.0422 0.0555
Loa Loa (eye worm) acetyltransferase 0.0164 0.454 0.454
Echinococcus multilocularis RUN 0.0019 0.0051 0.0022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0031 0.0422 0.0162
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0031 0.0422 0.0395
Brugia malayi TAZ zinc finger family protein 0.0117 0.309 0.309
Loa Loa (eye worm) Plcb4 protein 0.0039 0.0658 0.0658
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0117 0.3107 0.3072
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0422 0.0559
Brugia malayi Variant SH3 domain containing protein 0.0121 0.323 0.323
Brugia malayi glutamate synthase 0.0031 0.0422 0.0422
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0076 0.1804 0.1763
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0422 0.0422
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0031 0.0422 0.0559
Loa Loa (eye worm) glutathione reductase 0.0339 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0117 0.3107 1
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0051 0.0022
Toxoplasma gondii hypothetical protein 0.0052 0.1072 0.1072
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0117 0.3107 0.3107
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0051 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0117 0.3107 0.3107
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0031 0.0422 0.0555
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0029 0.0359 0.031
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0031 0.0422 0.0422
Plasmodium falciparum ferrodoxin reductase-like protein 0.0031 0.0422 0.0373
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0031 0.0422 0.0395
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0117 0.3107 0.3107
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.3107 0.292
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0164 0.454 0.4524
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0076 0.1804 0.5419
Schistosoma mansoni sulfide quinone reductase 0.0031 0.0422 0.0373
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0117 0.3107 0.3107
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0031 0.0422 0.0422
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0031 0.0422 0.0162
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0052 0.1072 0.1027
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0076 0.1804 0.5148
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0422 0.0422
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0121 0.323 0.323
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0031 0.0422 0.0559

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) > 30 uM Cytotoxicity against mouse L1210 cells ChEMBL. 23541671
MCC (ADMET) >= 100 uM Cytotoxicity against human HEL cells ChEMBL. 23541671

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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