Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.3128 | 0.2161 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0116 | 0.1234 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0336 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0116 | 0.1234 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3128 | 0.2161 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0116 | 0.1234 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0116 | 0.1234 | 0.1234 |
Leishmania major | trypanothione reductase | 0.0336 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3128 | 0.3128 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0336 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0116 | 0.1234 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3128 | 0.2161 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0116 | 0.1234 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0336 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0336 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0336 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0336 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0336 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.1234 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3128 | 0.2161 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0336 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.3128 | 0.2161 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0336 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0336 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.3128 | 0.2161 |
Plasmodium falciparum | glutathione reductase | 0.0336 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0116 | 0.1234 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3128 | 0.3128 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0116 | 0.1234 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0116 | 0.1234 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3128 | 0.2161 |
Toxoplasma gondii | thioredoxin reductase | 0.0336 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0336 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0116 | 0.1234 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0116 | 0.1234 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.03 uM | Inhibition of electric eel AChE using acetylcholine iodide as substrate incubated for 20 mins prior to substrate addition by Ellman method | ChEMBL. | 23562059 |
IC50 (binding) | = 11.02 uM | Inhibition of human serum BChE using butyrylthiolcholine iodide as substrate incubated for 20 mins prior to substrate addition by Ellman's method | ChEMBL. | 23562059 |
Ki (binding) | = 0.042 uM | Non-competitive inhibition of electric eel AChE using acetylcholine iodide as substrate by Lineweaver-Burk plot analysis | ChEMBL. | 23562059 |
Ki (binding) | = 15.64 uM | Competitive inhibition of human serum BChE using butyrylthiolcholine iodide as substrate by Lineweaver-Burk plot analysis | ChEMBL. | 23562059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.