Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0648 | 0.5 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0648 | 0.5 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0648 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0648 | 0.5 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0648 | 0.5 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0648 | 0.5 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0648 | 0.5 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0648 | 0.5 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0648 | 0.5 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.