Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0551 | 0.6558 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0702 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0333 | 0.1614 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0702 | 1 | 0.5 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0564 | 0.6867 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0564 | 0.6867 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0702 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0551 | 0.6558 | 0.9436 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0555 | 0.6651 | 0.6651 |
Mycobacterium ulcerans | thymidylate synthase | 0.0551 | 0.6558 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0564 | 0.6867 | 0.6867 |
Onchocerca volvulus | 0.0564 | 0.6867 | 1 | |
Schistosoma mansoni | 6-phosphofructokinase | 0.0564 | 0.6867 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 0.6651 | 0.9604 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0333 | 0.1614 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0333 | 0.1614 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0551 | 0.6558 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0396 | 0.305 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0555 | 0.6651 | 0.6651 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0551 | 0.6558 | 0.9191 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0564 | 0.6867 | 0.0646 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0564 | 0.6867 | 0.0646 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0396 | 0.305 | 0.3022 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0702 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0551 | 0.6558 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0551 | 0.6558 | 0.9191 |
Brugia malayi | Dihydrofolate reductase | 0.0396 | 0.305 | 0.4651 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0564 | 0.6867 | 0.6867 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0396 | 0.305 | 0.4651 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0262 | 0 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0551 | 0.6558 | 0.9191 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.6867 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0702 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0396 | 0.305 | 0.2905 |
Brugia malayi | dihydrofolate reductase family protein | 0.0396 | 0.305 | 0.4651 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.