Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | purinergic receptor P2Y, G-protein coupled, 1 | 373 aa | 393 aa | 17.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | redoxin domain-containing protein | 0.01 | 0.0766 | 0.1245 |
Brugia malayi | Dihydrofolate reductase | 0.0508 | 0.6058 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0508 | 0.6058 | 1 |
Onchocerca volvulus | 0.0256 | 0.2796 | 1 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0256 | 0.2796 | 0.4615 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0508 | 0.6058 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0508 | 0.6058 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0508 | 0.6058 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0508 | 0.6058 | 1 |
Leishmania major | biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 | 0.0521 | 0.6222 | 0.6222 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.6152 | 0.6201 |
Brugia malayi | thymidylate synthase | 0.0256 | 0.2796 | 0.3482 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0508 | 0.6058 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0122 | 0.1053 | 0.1738 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0508 | 0.6058 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0508 | 0.6058 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0122 | 0.1053 | 0.1711 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0122 | 0.1053 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.6152 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0508 | 0.6058 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0515 | 0.6152 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0256 | 0.2796 | 0.4615 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.6152 | 0.6152 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.6152 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0515 | 0.6152 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0806 | 0.992 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 90 nM | Displacement of [beta-33P]-2MeS-ADP from human P2Y1 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysis | ChEMBL. | 23668989 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.