Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | amyloid beta (A4) precursor protein | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131699 | All targets in OG5_131699 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131699 | All targets in OG5_131699 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | Get druggable targets OG5_131699 | All targets in OG5_131699 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131699 | All targets in OG5_131699 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Echinococcus multilocularis | peroxidasin | 0.0567 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0567 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Onchocerca volvulus | 0.0567 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Onchocerca volvulus | Peroxidasin homolog | 0.0567 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0369 | 0.5185 | 0.4849 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Brugia malayi | Animal haem peroxidase family protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Schistosoma mansoni | peroxidasin | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0567 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0567 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | notch protein | 0.0183 | 0.0654 | 0.0654 |
Echinococcus granulosus | peroxidasin | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0183 | 0.0654 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0567 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.3279 | 0.3279 |
Onchocerca volvulus | Dual oxidase homolog | 0.0567 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0183 | 0.0654 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Onchocerca volvulus | 0.0567 | 1 | 1 | |
Loa Loa (eye worm) | Notch2 | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Schistosoma mansoni | peroxidasin | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0567 | 1 | 1 |
Onchocerca volvulus | 0.0567 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0654 | 0.0654 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13.07 uM | Inhibition of self-mediated amyloid beta (1 to 42) aggregation (unknown origin) after 48 hrs by thioflavin T fluorescence assay | ChEMBL. | 23799643 |
Inhibition (binding) | = 62.5 % | Inhibition of self-mediated amyloid beta (1 to 42) aggregation (unknown origin) at 20 uM after 48 hrs by thioflavin T fluorescence assay relative to control | ChEMBL. | 23799643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.