Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | RUN | 0.01 | 0.1527 | 0.1303 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.083 | 0.1402 |
Giardia lamblia | AAA family ATPase | 0.0017 | 0.0114 | 0.5 |
Plasmodium falciparum | LCCL domain-containing protein | 0.01 | 0.1527 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0351 | 0.5772 | 0.5761 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.01 | 0.1527 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.083 | 0.1402 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0059 | 0.083 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0025 | 0.0257 | 0.0405 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0059 | 0.083 | 0.0588 |
Onchocerca volvulus | 0.0059 | 0.083 | 0.4516 | |
Schistosoma mansoni | rab6-interacting | 0.01 | 0.1527 | 0.1506 |
Echinococcus multilocularis | neuroligin | 0.0059 | 0.083 | 0.0808 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Trypanosoma brucei | Valosin-containing protein | 0.0027 | 0.0282 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0059 | 0.083 | 0.0808 |
Echinococcus granulosus | acetylcholinesterase | 0.0351 | 0.5772 | 0.566 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0028 | 0.0307 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.01 | 0.1527 | 0.1303 |
Schistosoma mansoni | acetylcholinesterase | 0.0059 | 0.083 | 0.0808 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0059 | 0.083 | 0.0808 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0059 | 0.083 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0025 | 0.0257 | 0.0405 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.01 | 0.1527 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.083 | 0.1402 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0059 | 0.083 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0059 | 0.083 | 0.0808 |
Schistosoma mansoni | rab6-interacting | 0.01 | 0.1527 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.083 | 0.1402 |
Schistosoma mansoni | polycystin 1-related | 0.01 | 0.1527 | 0.1506 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.01 | 0.1527 | 0.1506 |
Onchocerca volvulus | 0.0059 | 0.083 | 0.4516 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.083 | 0.1402 |
Onchocerca volvulus | 0.0059 | 0.083 | 0.4516 | |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0027 | 0.0282 | 0.1848 |
Schistosoma mansoni | lipoxygenase | 0.0419 | 0.6938 | 0.6931 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0027 | 0.0282 | 0.5 |
Schistosoma mansoni | loxhd1 | 0.01 | 0.1527 | 0.1506 |
Brugia malayi | Carboxylesterase family protein | 0.0351 | 0.5772 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0025 | 0.0257 | 0.0233 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.1527 | 0.1506 |
Echinococcus granulosus | carboxylesterase 5A | 0.0351 | 0.5772 | 0.566 |
Schistosoma mansoni | gliotactin | 0.0059 | 0.083 | 0.0808 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.5772 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0351 | 0.5772 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0059 | 0.083 | 0.1402 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0017 | 0.0114 | 0.0000097958 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0059 | 0.083 | 0.0808 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0059 | 0.083 | 0.0808 |
Loa Loa (eye worm) | carboxylesterase | 0.0059 | 0.083 | 0.1402 |
Loa Loa (eye worm) | carboxylesterase | 0.0059 | 0.083 | 0.1402 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0025 | 0.0257 | 0.0405 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0017 | 0.0108 | 0.0145 |
Brugia malayi | Animal haem peroxidase family protein | 0.0025 | 0.0257 | 0.0405 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.06 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.083 | 0.1402 |
Brugia malayi | hypothetical protein | 0.01 | 0.1527 | 0.2613 |
Onchocerca volvulus | 0.0059 | 0.083 | 0.4516 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Brugia malayi | Peroxidasin | 0.0025 | 0.0257 | 0.0405 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0059 | 0.083 | 1 |
Echinococcus granulosus | transitional endoplasmic reticulum atpase | 0.0028 | 0.0307 | 0.0051 |
Echinococcus multilocularis | acetylcholinesterase | 0.0351 | 0.5772 | 0.5761 |
Brugia malayi | Carboxylesterase family protein | 0.0059 | 0.083 | 0.1402 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Brugia malayi | Blistered cuticle protein 3 | 0.0025 | 0.0257 | 0.0405 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0027 | 0.0282 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Brugia malayi | Animal haem peroxidase family protein | 0.0025 | 0.0257 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0028 | 0.0307 | 0.0283 |
Schistosoma mansoni | peroxidasin | 0.0025 | 0.0257 | 0.0233 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.01 | 0.1527 | 0.1303 |
Brugia malayi | hypothetical protein | 0.01 | 0.1527 | 0.2613 |
Brugia malayi | Carboxylesterase family protein | 0.0059 | 0.083 | 0.1402 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0025 | 0.0257 | 0.0405 |
Brugia malayi | Doublecortin family protein | 0.01 | 0.1527 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Brugia malayi | vesicle-fusing ATPase | 0.0017 | 0.0108 | 0.0145 |
Onchocerca volvulus | 0.01 | 0.1527 | 1 | |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.01 | 0.1527 | 0.1303 |
Onchocerca volvulus | 0.0059 | 0.083 | 0.4516 | |
Schistosoma mansoni | lipoxygenase | 0.06 | 1 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0028 | 0.0307 | 0.0391 |
Echinococcus granulosus | neuroligin | 0.0059 | 0.083 | 0.0588 |
Brugia malayi | hypothetical protein | 0.0059 | 0.083 | 0.1402 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1527 | 0.2613 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0025 | 0.0257 | 0.0405 |
Brugia malayi | Carboxylesterase family protein | 0.0059 | 0.083 | 0.1402 |
Onchocerca volvulus | 0.01 | 0.1527 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1527 | 0.2613 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0059 | 0.083 | 0.0808 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0059 | 0.083 | 0.0588 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0059 | 0.083 | 0.0808 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0059 | 0.083 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0351 | 0.5772 | 0.566 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0027 | 0.0282 | 0.0258 |
Brugia malayi | Animal haem peroxidase family protein | 0.0025 | 0.0257 | 0.0405 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0059 | 0.083 | 0.0588 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0059 | 0.083 | 0.0808 |
Brugia malayi | Animal haem peroxidase family protein | 0.0025 | 0.0257 | 0.0405 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0028 | 0.0307 | 1 |
Echinococcus multilocularis | RUN | 0.01 | 0.1527 | 0.1506 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0027 | 0.0282 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0027 | 0.0282 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.083 | 0.1402 |
Brugia malayi | Carboxylesterase family protein | 0.0351 | 0.5772 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0351 | 0.5772 | 0.5761 |
Echinococcus multilocularis | acetylcholinesterase | 0.0351 | 0.5772 | 0.5761 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.5772 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0351 | 0.5772 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.01 | 0.1527 | 1 |
Brugia malayi | valosin containing protein | 0.0017 | 0.0108 | 0.0145 |
Schistosoma mansoni | peroxidasin | 0.0025 | 0.0257 | 0.0233 |
Loa Loa (eye worm) | doublecortin family protein | 0.01 | 0.1527 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0257 | 0.0405 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0059 | 0.083 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0025 | 0.0257 | 0.0405 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM | Antitrypanosomal activity against Trypanosoma brucei | ChEMBL. | 23611656 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.