Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0018 | 0.0032 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0048 | 0.0121 | 0.0192 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0035 | 0.0078 | 0.0078 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0156 | 0.0468 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0078 | 0.2039 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0079 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0078 | 0.0078 |
Brugia malayi | WGR domain containing protein | 0.0116 | 0.034 | 0.034 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0156 | 0.0468 | 0.0744 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0331 | 0.1032 | 0.1032 |
Leishmania major | cytochrome p450-like protein | 0.003 | 0.006 | 0.1568 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | nuclear hormone receptor | 0.0156 | 0.0468 | 0.0744 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0018 | 0.0018 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.0036 | 0.0079 | 0.2059 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0187 | 0.0566 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0175 | 0.0528 | 0.0528 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.013 | 0.0384 | 0.9367 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.013 | 0.0384 | 0.0384 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0156 | 0.0468 | 0.0744 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0331 | 0.1032 | 0.1032 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0112 | 0.0327 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.3112 | 1 | 1 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.013 | 0.0384 | 0.627 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.013 | 0.0384 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0078 | 0.0078 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0187 | 0.0566 | 1 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0187 | 0.0566 | 0.0566 |
Schistosoma mansoni | geranylgeranyl transferase type II beta subunit | 0.0035 | 0.0078 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0331 | 0.1032 | 0.1032 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0036 | 0.0079 | 0.0016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0079 | 0.0016 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0018 | 0.0018 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0048 | 0.0121 | 0.3136 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0331 | 0.1032 | 0.1032 |
Plasmodium falciparum | Appr-1-p processing domain protein | 0.0036 | 0.0079 | 0.0016 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0156 | 0.0468 | 0.0817 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0187 | 0.0566 | 1 |
Mycobacterium tuberculosis | Possible lipoprotein LppD | 0.0036 | 0.0079 | 1 |
Onchocerca volvulus | 0.0156 | 0.0468 | 0.0392 | |
Brugia malayi | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0035 | 0.0078 | 0.0125 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0175 | 0.0528 | 0.0528 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0175 | 0.0528 | 0.084 |
Brugia malayi | Tnks protein | 0.0173 | 0.0523 | 0.0523 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0566 | 0.0566 |
Giardia lamblia | Phosphatase similar to the C-terminal domain of histone macroH2A1 | 0.0036 | 0.0079 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0081 | 0.0129 |
Giardia lamblia | Protein LRP16 | 0.0036 | 0.0079 | 0.0016 |
Brugia malayi | WGR domain containing protein | 0.0112 | 0.0327 | 0.0327 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0079 | 0.0126 |
Trypanosoma cruzi | geranylgeranyl transferase type II beta subunit, putative | 0.0035 | 0.0078 | 0.2039 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0112 | 0.0327 | 0.8506 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0156 | 0.0468 | 0.0392 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | ecdysone receptor | 0.0156 | 0.0468 | 0.0468 |
Echinococcus granulosus | H2A histone family member Y | 0.0036 | 0.0079 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Toxoplasma gondii | hypothetical protein | 0.0138 | 0.041 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0156 | 0.0468 | 0.0468 |
Mycobacterium leprae | putative cytochrome p450 | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0138 | 0.041 | 0.6802 |
Brugia malayi | nuclear receptor RXR | 0.0175 | 0.0528 | 0.0528 |
Brugia malayi | nuclear hormone receptor | 0.0156 | 0.0468 | 0.0468 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0018 | 0.0029 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.0048 | 0.0121 | 0.0192 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0187 | 0.0566 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0156 | 0.0468 | 0.0817 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0048 | 0.0121 | 0.3136 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.014 | 0.014 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0081 | 0.0081 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0331 | 0.1032 | 0.1802 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0331 | 0.1032 | 0.164 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0331 | 0.1032 | 0.1032 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0187 | 0.0566 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0331 | 0.1032 | 0.1802 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.0048 | 0.0121 | 0.0864 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0035 | 0.0078 | 0.0137 |
Leishmania major | geranylgeranyltransferase, putative | 0.0035 | 0.0078 | 0.2039 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Onchocerca volvulus | 0.0331 | 0.1032 | 0.0961 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Brugia malayi | steroid hormone receptor | 0.0331 | 0.1032 | 0.1032 |
Onchocerca volvulus | 0.0048 | 0.0121 | 0.0042 | |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | nuclear receptor | 0.0156 | 0.0468 | 0.0744 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0331 | 0.1032 | 0.164 |
Brugia malayi | hypothetical protein | 0.0251 | 0.0774 | 0.0774 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0331 | 0.1032 | 0.1032 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0112 | 0.0327 | 0.5093 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0112 | 0.0327 | 0.0571 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.3136 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0035 | 0.0078 | 0.2039 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0035 | 0.0078 | 0.0078 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.0036 | 0.0079 | 0.2059 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0112 | 0.0327 | 0.8506 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1787 | 0.5728 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0331 | 0.1032 | 0.164 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0331 | 0.1032 | 0.1802 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | DR-78 | 0.0156 | 0.0468 | 0.0468 |
Onchocerca volvulus | 0.0051 | 0.013 | 0.0051 | |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0018 | 0.0029 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0331 | 0.1032 | 0.1032 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0331 | 0.1032 | 0.1802 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0036 | 0.0079 | 0.0126 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0331 | 0.1032 | 0.164 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0331 | 0.1032 | 0.1032 |
Toxoplasma gondii | Rab geranylgeranyl transferase type II beta subunit, putative | 0.0035 | 0.0078 | 0.191 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0331 | 0.1032 | 0.164 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0187 | 0.0566 | 0.09 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1962 | 0.6291 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0331 | 0.1032 | 0.164 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.0864 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0187 | 0.0566 | 0.0989 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.3136 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.0864 |
Trypanosoma brucei | cytochrome P450, putative | 0.003 | 0.006 | 0.1568 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0018 | 0.0029 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0331 | 0.1032 | 0.164 |
Brugia malayi | nuclear hormone receptor | 0.0331 | 0.1032 | 0.1032 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0036 | 0.0079 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0135 | 0.0135 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0156 | 0.0468 | 0.0817 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0331 | 0.1032 | 0.164 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0156 | 0.0468 | 0.0744 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0331 | 0.1032 | 0.164 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0187 | 0.0566 | 0.09 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0156 | 0.0468 | 0.0468 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0036 | 0.0079 | 0.0016 |
Echinococcus granulosus | tankyrase | 0.0174 | 0.0526 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.0774 | 0.0774 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0048 | 0.0121 | 0.0121 |
Schistosoma mansoni | tankyrase | 0.0174 | 0.0527 | 0.0837 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0331 | 0.1032 | 0.1032 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0156 | 0.0468 | 0.0744 |
Leishmania major | farnesyltransferase beta subunit | 0.013 | 0.0384 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0018 | 0.0032 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0018 | 0.0029 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0331 | 0.1032 | 0.164 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0331 | 0.1032 | 0.1032 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.3136 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0112 | 0.0327 | 0.8506 |
Echinococcus multilocularis | geminin | 0.018 | 0.0544 | 0.095 |
Mycobacterium ulcerans | lipoprotein LppD | 0.0036 | 0.0079 | 1 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0187 | 0.0566 | 0.0566 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0187 | 0.0566 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.0864 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0175 | 0.0528 | 0.084 |
Trypanosoma brucei | Macro domain containing protein, putative | 0.0036 | 0.0079 | 0.2059 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0035 | 0.0078 | 0.9903 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.013 | 0.0384 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0331 | 0.1032 | 0.164 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0018 | 0.0029 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0331 | 0.1032 | 0.1802 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0331 | 0.1032 | 0.1802 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0331 | 0.1032 | 0.164 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.0048 | 0.0121 | 0.021 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0121 | 0.2937 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0112 | 0.0327 | 0.052 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.034 | 0.034 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0331 | 0.1032 | 0.1802 |
Echinococcus granulosus | geminin | 0.018 | 0.0544 | 0.0865 |
Brugia malayi | conserved hypotetical protein | 0.0156 | 0.0468 | 0.0468 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Brugia malayi | nuclear receptor RXR | 0.0156 | 0.0468 | 0.0468 |
Onchocerca volvulus | 0.0156 | 0.0468 | 0.0392 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Schistosoma mansoni | nuclear receptor | 0.0156 | 0.0468 | 0.0744 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0156 | 0.0468 | 0.0817 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0048 | 0.0121 | 0.3136 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0135 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0018 | 0.0029 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0035 | 0.0078 | 0.2039 |
Echinococcus granulosus | FTZ F1 alpha | 0.0331 | 0.1032 | 0.164 |
Brugia malayi | Probable protein farnesyltransferase beta subunit, putative | 0.0035 | 0.0078 | 0.0078 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0156 | 0.0468 | 0.0744 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.013 | 0.0384 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.006 | 0.1568 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0018 | 0.0029 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0036 | 0.0079 | 0.0016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.013 | 0.0206 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.013 | 0.0384 | 0.0611 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0175 | 0.0528 | 0.0528 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0018 | 0.0018 |
Entamoeba histolytica | zinc finger protein, putative | 0.0112 | 0.0327 | 0.5093 |
Loa Loa (eye worm) | CYP4Cod1 | 0.003 | 0.006 | 0.006 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0156 | 0.0468 | 0.0744 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0331 | 0.1032 | 0.164 |
Echinococcus multilocularis | H2A histone family, member Y | 0.0036 | 0.0079 | 0.0138 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Schistosoma mansoni | nuclear hormone receptor | 0.0331 | 0.1032 | 0.164 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0175 | 0.0528 | 0.084 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0035 | 0.0078 | 0.191 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0331 | 0.1032 | 0.1032 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Onchocerca volvulus | Bile acid receptor homolog | 0.3112 | 1 | 1 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.013 | 0.0384 | 0.0611 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0251 | 0.0774 | 0.1351 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0156 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0331 | 0.1032 | 0.164 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.3136 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0156 | 0.0468 | 0.0817 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.0112 | 0.0327 | 0.0571 |
Brugia malayi | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Brugia malayi | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0095 | 0.027 | 0.3936 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0175 | 0.0528 | 0.0923 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0156 | 0.0468 | 0.0468 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0048 | 0.0121 | 0.3136 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.013 | 0.0384 | 1 |
Brugia malayi | Appr-1-p processing enzyme family protein | 0.0036 | 0.0079 | 0.0079 |
Giardia lamblia | Prenyltransferase | 0.013 | 0.0384 | 0.627 |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0112 | 0.0327 | 0.0571 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0156 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0156 | 0.0468 | 0.0468 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Onchocerca volvulus | Tankyrase homolog | 0.0167 | 0.0502 | 0.0427 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0544 | 0.0865 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0331 | 0.1032 | 0.164 |
Trypanosoma brucei | geranylgeranyl transferase type II beta subunit, putative | 0.0035 | 0.0078 | 0.2039 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Trypanosoma brucei | lanosterol synthase | 0.0035 | 0.0078 | 0.2039 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0078 | 0.2039 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0048 | 0.0121 | 0.3136 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0331 | 0.1032 | 0.1032 |
Echinococcus multilocularis | Rab geranylgeranyltransferase, beta subunit | 0.0035 | 0.0078 | 0.0137 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0331 | 0.1032 | 0.1032 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0331 | 0.1032 | 0.1802 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0187 | 0.0566 | 1 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0331 | 0.1032 | 0.1032 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Brugia malayi | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0048 | 0.0121 | 0.0121 |
Schistosoma mansoni | thyroid hormone receptor | 0.0331 | 0.1032 | 0.164 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0544 | 0.0865 |
Schistosoma mansoni | nuclear hormone receptor | 0.0156 | 0.0468 | 0.0744 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0156 | 0.0468 | 0.0744 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.013 | 0.0206 |
Toxoplasma gondii | macro domain-containing protein | 0.0036 | 0.0079 | 0.1929 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.013 | 0.0384 | 0.0384 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0036 | 0.0079 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0081 | 0.0081 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0331 | 0.1032 | 0.1802 |
Schistosoma mansoni | coup transcription factor | 0.0331 | 0.1032 | 0.164 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0036 | 0.0079 | 0.0126 |
Brugia malayi | tailless protein | 0.0156 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.006 | 0.1568 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.0048 | 0.0121 | 0.0192 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0156 | 0.0468 | 0.0392 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0135 | 0.0135 |
Schistosoma mansoni | zinc finger protein | 0.0156 | 0.0468 | 0.0744 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0156 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0331 | 0.1032 | 0.1032 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0331 | 0.1032 | 0.164 |
Toxoplasma gondii | hypothetical protein | 0.0036 | 0.0079 | 0.1929 |
Brugia malayi | nuclear receptor NHR-88 | 0.0331 | 0.1032 | 0.1032 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0018 | 0.0032 |
Loa Loa (eye worm) | tnks protein | 0.0168 | 0.0506 | 0.0506 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0331 | 0.1032 | 0.0961 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0156 | 0.0468 | 0.0468 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0036 | 0.0079 | 0.0138 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.0048 | 0.0121 | 0.021 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Brugia malayi | nuclear receptor NHR-88 | 0.0156 | 0.0468 | 0.0468 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0036 | 0.0079 | 0.0016 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0156 | 0.0468 | 0.0744 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.003 | 0.006 | 0.7614 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0112 | 0.0327 | 0.052 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0035 | 0.0078 | 0.0125 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0112 | 0.0327 | 0.7968 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0112 | 0.0327 | 0.052 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0036 | 0.0079 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0112 | 0.0327 | 0.0327 |
Echinococcus multilocularis | tankyrase | 0.0174 | 0.0526 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0331 | 0.1032 | 0.1032 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1962 | 0.6291 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0135 | 0.0135 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0035 | 0.0078 | 0.0125 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0251 | 0.0774 | 0.123 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.0048 | 0.0121 | 0.3136 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0036 | 0.0079 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0331 | 0.1032 | 0.0961 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0048 | 0.0121 | 0.0864 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 54 % | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 250 ug/ml after 12 to 28 days by Lowenstein-Jensen method relative to control | ChEMBL. | 23747804 |
MIC (functional) | = 250 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition by broth microdilution method | ChEMBL. | 23747804 |
MIC (functional) | = 250 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition by broth microdilution method | ChEMBL. | 23747804 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.