TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 583.634 | Formula: C32H33N5O6
H donors: 2 H acceptors: 5 LogP: 3.4 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: C=CCn1c(=O)c(cc2c1ccc(c2)OC)C1C(=C(N)N(C2=C1C(=O)CCC2)NC(=O)c1ccncc1)C(=O)OC(C)C
InChi: 1S/C32H33N5O6/c1-5-15-36-23-10-9-21(42-4)16-20(23)17-22(31(36)40)26-27-24(7-6-8-25(27)38)37(29(33)28(26)32(41)43-18(2)3)35-30(39)19-11-13-34-14-12-19/h5,9-14,16-18,26H,1,6-8,15,33H2,2-4H3,(H,35,39)
InChiKey: QZOKSQHTMCNROZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0187	0.0566	1
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0095	0.027	0.3936
Entamoeba histolytica	hypothetical protein	0.0112	0.0327	0.5093
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0018	0.0029
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0175	0.0528	0.084
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0112	0.0327	0.5093
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0112	0.0327	0.0571
Trypanosoma cruzi	protein farnesyltransferase, putative	0.013	0.0384	1
Schistosoma mansoni	nuclear hormone receptor	0.0331	0.1032	0.164
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0048	0.0121	0.0192
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0156	0.0468	0.0817
Schistosoma mansoni	tankyrase	0.0174	0.0527	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0025	0.0025
Brugia malayi	Tnks protein	0.0173	0.0523	0.0523
Schistosoma mansoni	zinc finger protein	0.0156	0.0468	0.0744
Schistosoma mansoni	nuclear receptor nhr-48	0.0156	0.0468	0.0744
Mycobacterium ulcerans	lipoprotein LppD	0.0036	0.0079	1
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0116	0.034	0.034
Brugia malayi	nuclear hormone receptor	0.0156	0.0468	0.0468
Giardia lamblia	Rab geranylgeranyltransferase	0.0187	0.0566	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0331	0.1032	0.1032
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0175	0.0528	0.084
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0048	0.0121	0.021
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0331	0.1032	0.164
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0048	0.0121	0.3136
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0156	0.0468	0.0744
Brugia malayi	steroid hormone receptor	0.0331	0.1032	0.1032
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0331	0.1032	0.1802
Schistosoma mansoni	thyroid hormone receptor	0.0331	0.1032	0.164
Schistosoma mansoni	nuclear receptor	0.0156	0.0468	0.0744
Brugia malayi	nuclear receptor NHR-88	0.0156	0.0468	0.0468
Loa Loa (eye worm)	steroid hormone receptor	0.0331	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0035	0.0078	0.191
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0331	0.1032	0.1032
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0078	0.2039
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.013	0.0384	0.9367
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.013	0.0384	0.0384
Schistosoma mansoni	hypothetical protein	0.0051	0.013	0.0206
Brugia malayi	hypothetical protein	0.0156	0.0468	0.0468
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.1962	0.6291	1
Schistosoma mansoni	nuclear receptor	0.0156	0.0468	0.0744
Echinococcus multilocularis	survival motor neuron protein 1	0.0251	0.0774	0.1351
Echinococcus granulosus	MACRO domain containing protein 2	0.0036	0.0079	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0331	0.1032	0.1032
Echinococcus multilocularis	nuclear receptor nhr 48	0.0156	0.0468	0.0817
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0327	0.5093
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0331	0.1032	0.1032
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0018	0.0018
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0156	0.0468	0.0392
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0331	0.1032	0.1032
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0078	0.2039
Brugia malayi	conserved hypotetical protein	0.0156	0.0468	0.0468
Echinococcus granulosus	ecdysone induced protein 78C	0.0331	0.1032	0.164
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0112	0.0327	0.8506
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0331	0.1032	0.164
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0331	0.1032	0.1032
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0331	0.1032	0.164
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Brugia malayi	hypothetical protein	0.0175	0.0528	0.0528
Brugia malayi	Nuclear hormone receptor E75	0.0156	0.0468	0.0468
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0187	0.0566	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0331	0.1032	0.1802
Schistosoma mansoni	thyroid hormone receptor	0.0331	0.1032	0.164
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.006	0.006
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0018	0.0018
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0048	0.0121	0.0192
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0079	0.0016
Trypanosoma brucei	Macro domain containing protein, putative	0.0036	0.0079	0.2059
Echinococcus granulosus	H2A histone family member Y	0.0036	0.0079	0.0126
Brugia malayi	Nuclear hormone receptor E75	0.0156	0.0468	0.0468
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0112	0.0327	0.0327
Schistosoma mansoni	hypothetical protein	0.0036	0.0079	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0327	0.5093
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0528	0.0528
Schistosoma mansoni	retinoic acid receptor RXR	0.1962	0.6291	1
Loa Loa (eye worm)	DR-78	0.0156	0.0468	0.0468
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0156	0.0468	0.0744
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.013	0.0384	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0528	0.0528
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0018	0.0032
Echinococcus granulosus	tankyrase	0.0174	0.0526	0.0836
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0035	0.0078	0.9903
Echinococcus multilocularis	ecdysone induced protein 78C	0.0331	0.1032	0.1802
Onchocerca volvulus	Protein ultraspiracle homolog	0.0331	0.1032	0.0961
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0018	0.0032
Brugia malayi	nuclear hormone receptor family member odr-7	0.0156	0.0468	0.0468
Echinococcus multilocularis	MACRO domain containing protein 2	0.0036	0.0079	0.0138
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0018	0.0029
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0331	0.1032	0.164
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0331	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0566	0.0566
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0331	0.1032	0.164
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0331	0.1032	0.1032
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0327	0.5093
Echinococcus granulosus	poly adp ribose polymerase 2	0.0112	0.0327	0.052
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0327	0.5093
Entamoeba histolytica	hypothetical protein	0.0112	0.0327	0.5093
Schistosoma mansoni	nuclear hormone receptor	0.0156	0.0468	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0135	0.0135
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0112	0.0327	0.8506
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0156	0.0468	0.0817
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0112	0.0327	0.0571
Brugia malayi	nuclear receptor RXR	0.0156	0.0468	0.0468
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.013	0.0384	0.0671
Trichomonas vaginalis	ganglioside induced differentiation associated protein, putative	0.0036	0.0079	0.0016
Brugia malayi	nuclear receptor NHR-88	0.0331	0.1032	0.1032
Echinococcus multilocularis	geminin	0.018	0.0544	0.095
Brugia malayi	Nuclear hormone receptor-like 1	0.0175	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.3112	1	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0156	0.0468	0.0468
Echinococcus multilocularis	tankyrase	0.0174	0.0526	0.0919
Echinococcus granulosus	GPCR family 2	0.0017	0.0018	0.0029
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0048	0.0121	0.3136
Brugia malayi	tailless protein	0.0156	0.0468	0.0468
Echinococcus multilocularis	FTZ F1 alpha	0.0331	0.1032	0.1802
Leishmania major	geranylgeranyltransferase, putative	0.0035	0.0078	0.2039
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0081	0.0081
Giardia lamblia	Prenyltransferase	0.013	0.0384	0.627
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0331	0.1032	0.1032
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0112	0.0327	0.052
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0331	0.1032	0.1032
Schistosoma mansoni	hypothetical protein	0.0017	0.0018	0.0029
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0331	0.1032	0.164
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0078	0.0078
Entamoeba histolytica	zinc finger protein, putative	0.0112	0.0327	0.5093
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0048	0.0121	0.0192
Entamoeba histolytica	hypothetical protein	0.0112	0.0327	0.5093
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.013	0.0384	0.0611
Loa Loa (eye worm)	tnks protein	0.0168	0.0506	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0331	0.1032	0.1032
Trichomonas vaginalis	ganglioside induced differentiation associated protein, putative	0.0036	0.0079	0.0016
Schistosoma mansoni	survival motor neuron protein	0.0051	0.013	0.0206
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.003	0.006	0.7614
Trypanosoma brucei	cytochrome P450, putative	0.003	0.006	0.1568
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0187	0.0566	1
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0035	0.0078	0.0125
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0048	0.0121	0.021
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0138	0.041	0.6802
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0156	0.0468	0.0468
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0112	0.0327	0.0571
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.013	0.0384	0.627
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1787	0.5728	1
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0079	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0327	0.5093
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0048	0.0121	0.3136
Brugia malayi	Steroid receptor seven-up type 2	0.0331	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0528	0.0528
Toxoplasma gondii	hypothetical protein	0.0048	0.0121	0.2937
Onchocerca volvulus		0.0156	0.0468	0.0392
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0035	0.0078	0.0078
Mycobacterium tuberculosis	Possible lipoprotein LppD	0.0036	0.0079	1
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.013	0.0384	0.627
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Plasmodium falciparum	Appr-1-p processing domain protein	0.0036	0.0079	0.0016
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0079	0.0016
Giardia lamblia	Rab geranylgeranyltransferase	0.0048	0.0121	0.0864
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0121	0.3136
Toxoplasma gondii	macro domain-containing protein	0.0036	0.0079	0.1929
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0156	0.0468	0.0744
Brugia malayi	WGR domain containing protein	0.0112	0.0327	0.0327
Mycobacterium leprae	putative cytochrome p450	0.0011	0	0.5
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0048	0.0121	0.0864
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0331	0.1032	0.1032
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0327	0.5093
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0156	0.0468	0.0744
Trypanosoma cruzi	lanosterol synthase, putative	0.0035	0.0078	0.2039
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0331	0.1032	0.164
Brugia malayi	nuclear receptor NHR-67	0.0156	0.0468	0.0468
Schistosoma mansoni	hypothetical protein	0.018	0.0544	0.0865
Schistosoma mansoni	hypothetical protein	0.0036	0.0079	0.0126
Brugia malayi	Nuclear hormone receptor-like 1	0.0331	0.1032	0.1032
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0331	0.1032	0.1032
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0331	0.1032	0.1032
Brugia malayi	Cytochrome P450 family protein	0.003	0.006	0.006
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.013	0.0384	0.627
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0187	0.0566	1
Entamoeba histolytica	hypothetical protein, conserved	0.0036	0.0079	0.0016
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0048	0.0121	0.0864
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0035	0.0078	0.0125
Trichomonas vaginalis	ganglioside induced differentiation associated protein, putative	0.0036	0.0079	0.0016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0331	0.1032	0.1032
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.013	0.0384	0.627
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0048	0.0121	0.0121
Brugia malayi	Nuclear hormone receptor-like 1	0.0175	0.0528	0.0528
Onchocerca volvulus		0.0331	0.1032	0.0961
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0331	0.1032	0.1032
Echinococcus granulosus	geminin	0.018	0.0544	0.0865
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0048	0.0121	0.0864
Leishmania major	cytochrome p450-like protein	0.003	0.006	0.1568
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0331	0.1032	0.164
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0112	0.0327	0.052
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0331	0.1032	0.164
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.013	0.0384	0.627
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0774	0.0774
Echinococcus granulosus	FTZ F1 alpha	0.0331	0.1032	0.164
Brugia malayi	Cytochrome P450 family protein	0.003	0.006	0.006
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.013	0.0384	0.627
Echinococcus granulosus	survival motor neuron protein 1	0.0251	0.0774	0.123
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0331	0.1032	0.1032
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.006	0.006
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.013	0.0384	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0156	0.0468	0.0392
Brugia malayi	hypothetical protein	0.0251	0.0774	0.0774
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0035	0.0078	0.0078
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0048	0.0121	0.3136
Giardia lamblia	Protein LRP16	0.0036	0.0079	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0331	0.1032	0.1032
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0331	0.1032	0.1802
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0135	0.0135
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0156	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0528	0.0528
Trypanosoma cruzi	Macro domain containing protein, putative	0.0036	0.0079	0.2059
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0175	0.0528	0.0528
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.013	0.0384	0.627
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0331	0.1032	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0081	0.0081
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0175	0.0528	0.084
Giardia lamblia	Phosphatase similar to the C-terminal domain of histone macroH2A1	0.0036	0.0079	0.0016
Trypanosoma cruzi	protein farnesyltransferase, putative	0.013	0.0384	1
Schistosoma mansoni	hypothetical protein	0.018	0.0544	0.0865
Echinococcus granulosus	MACRO domain containing protein 2	0.0036	0.0079	0.0126
Echinococcus multilocularis	MACRO domain containing protein 2	0.0036	0.0079	0.0138
Loa Loa (eye worm)	nuclear hormone receptor	0.0156	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0331	0.1032	0.1032
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0187	0.0566	0.09
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0331	0.1032	0.164
Loa Loa (eye worm)	hypothetical protein	0.0055	0.014	0.014
Echinococcus granulosus	nuclear receptor nhr 48	0.0156	0.0468	0.0744
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0331	0.1032	0.164
Trypanosoma cruzi	lanosterol synthase, putative	0.0035	0.0078	0.2039
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0036	0.0079	1
Entamoeba histolytica	hypothetical protein	0.0112	0.0327	0.5093
Loa Loa (eye worm)	hypothetical protein	0.0331	0.1032	0.1032
Onchocerca volvulus	Tankyrase homolog	0.0167	0.0502	0.0427
Echinococcus multilocularis	H2A histone family, member Y	0.0036	0.0079	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0035	0.0078	0.2039
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0331	0.1032	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0018	0.0018
Trypanosoma brucei	lanosterol synthase	0.0035	0.0078	0.2039
Schistosoma mansoni	hypothetical protein	0.0017	0.0018	0.0029
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0156	0.0468	0.0744
Onchocerca volvulus		0.0051	0.013	0.0051
Onchocerca volvulus	Bile acid receptor homolog	0.3112	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.0036	0.0079	0.0016
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0048	0.0121	0.3136
Onchocerca volvulus		0.0156	0.0468	0.0392
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0036	0.0079	0.0016
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0035	0.0078	0.0137
Brugia malayi	photoreceptor-specific nuclear receptor	0.0331	0.1032	0.1032
Schistosoma mansoni	hypothetical protein	0.0017	0.0018	0.0029
Brugia malayi	hypothetical protein	0.0156	0.0468	0.0468
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0121	0.3136
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0035	0.0078	0.191
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0112	0.0327	0.052
Brugia malayi	ecdysone receptor	0.0156	0.0468	0.0468
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0327	0.5093
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0035	0.0078	0.0078
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0187	0.0566	0.09
Schistosoma mansoni	nuclear hormone receptor	0.0156	0.0468	0.0744
Brugia malayi	WGR domain containing protein	0.0116	0.034	0.034
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0135	0.0135
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0079	0.0016
Entamoeba histolytica	hypothetical protein, conserved	0.0036	0.0079	0.0016
Schistosoma mansoni	coup transcription factor	0.0331	0.1032	0.164
Trypanosoma cruzi	Macro domain containing protein, putative	0.0036	0.0079	0.2059
Schistosoma mansoni	RAR-like nuclear receptor	0.0331	0.1032	0.164
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0018	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0078	0.0078
Brugia malayi	nuclear receptor RXR	0.0175	0.0528	0.0528
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0327	0.5093
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.013	0.0384	0.627
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0331	0.1032	0.164
Trypanosoma cruzi	cytochrome P450, putative	0.003	0.006	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0331	0.1032	0.1032
Toxoplasma gondii	hypothetical protein	0.0138	0.041	1
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0112	0.0327	0.7968
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.013	0.013
Onchocerca volvulus		0.0048	0.0121	0.0042
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0156	0.0468	0.0744
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.013	0.0384	0.0611
Brugia malayi	hypothetical protein	0.0175	0.0528	0.0528
Loa Loa (eye worm)	CYP4Cod1	0.003	0.006	0.006
Brugia malayi	nuclear hormone receptor	0.0331	0.1032	0.1032
Trichomonas vaginalis	ganglioside induced differentiation associated protein, putative	0.0036	0.0079	0.0016
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0156	0.0468	0.0817
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0187	0.0566	0.0989
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0048	0.0121	0.3136
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0327	0.5093
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0331	0.1032	0.1032
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0187	0.0566	0.0566
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0187	0.0566	1
Toxoplasma gondii	hypothetical protein	0.0036	0.0079	0.1929
Brugia malayi	Appr-1-p processing enzyme family protein	0.0036	0.0079	0.0079
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0112	0.0327	0.8506
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0331	0.1032	0.1032
Leishmania major	farnesyltransferase beta subunit	0.013	0.0384	1
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0187	0.0566	0.0566
Echinococcus granulosus	thyroid hormone receptor alpha	0.0156	0.0468	0.0744
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0018	0.0018
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0035	0.0078	0.0125
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0036	0.0079	0.0016
Trypanosoma brucei	hypothetical protein, conserved	0.0048	0.0121	0.3136
Brugia malayi	Cytochrome P450 family protein	0.003	0.006	0.006
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0331	0.1032	0.1802
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0331	0.1032	0.1802
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0331	0.1032	0.164
Loa Loa (eye worm)	hypothetical protein	0.0331	0.1032	0.1032
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0175	0.0528	0.0923
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0156	0.0468	0.0468
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0135	0.0135
Brugia malayi	orphan nuclear receptor NR2E1	0.0156	0.0468	0.0468
Mycobacterium leprae	Conserved hypothetical protein	0.0011	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0331	0.1032	0.1802
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0331	0.1032	0.1032
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0048	0.0121	0.3136
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0079	0.0079
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0048	0.0121	0.0864
Schistosoma mansoni	hypothetical protein	0.0017	0.0018	0.0029
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0035	0.0078	0.2039
Trypanosoma cruzi	cytochrome P450, putative	0.003	0.006	0.1568
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0048	0.0121	0.0121
Schistosoma mansoni	hypothetical protein	0.0036	0.0081	0.0129
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.013	0.0384	0.627
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0331	0.1032	0.1032
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0035	0.0078	0.0125
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0331	0.1032	0.1032
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0187	0.0566	1
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0468	0.0468
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0156	0.0468	0.0817
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0035	0.0078	0.0137

Activities

Activity type	Activity value	Assay description	Source	Reference
GI (functional)	= 27 %	Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 250 ug/ml after 12 to 28 days by Lowenstein-Jensen method relative to control	ChEMBL.	23747804
MIC (functional)	= 200 ug ml-1	Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition by broth microdilution method	ChEMBL.	23747804
MIC (functional)	= 250 ug ml-1	Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition by broth microdilution method	ChEMBL.	23747804

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2402132

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1780886