Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | tailless protein | 0.0156 | 0.0468 | 0.0468 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.006 | 0.1568 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0331 | 0.1032 | 0.1802 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0081 | 0.0081 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Schistosoma mansoni | coup transcription factor | 0.0331 | 0.1032 | 0.164 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0036 | 0.0079 | 0.0126 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0036 | 0.0079 | 0.0016 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0331 | 0.1032 | 0.1032 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0331 | 0.1032 | 0.164 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | zinc finger protein | 0.0156 | 0.0468 | 0.0744 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0156 | 0.0468 | 0.0468 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.0048 | 0.0121 | 0.0192 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0156 | 0.0468 | 0.0392 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0135 | 0.0135 |
Schistosoma mansoni | thyroid hormone receptor | 0.0331 | 0.1032 | 0.164 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Brugia malayi | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0048 | 0.0121 | 0.0121 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0331 | 0.1032 | 0.1032 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0331 | 0.1032 | 0.1802 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0187 | 0.0566 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.013 | 0.0384 | 0.0384 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.013 | 0.0206 |
Toxoplasma gondii | macro domain-containing protein | 0.0036 | 0.0079 | 0.1929 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0544 | 0.0865 |
Schistosoma mansoni | nuclear hormone receptor | 0.0156 | 0.0468 | 0.0744 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0156 | 0.0468 | 0.0744 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0135 | 0.0135 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0331 | 0.1032 | 0.1032 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1962 | 0.6291 | 1 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0112 | 0.0327 | 0.0327 |
Echinococcus multilocularis | tankyrase | 0.0174 | 0.0526 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0036 | 0.0079 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0331 | 0.1032 | 0.0961 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0048 | 0.0121 | 0.0864 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.0048 | 0.0121 | 0.3136 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0251 | 0.0774 | 0.123 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0035 | 0.0078 | 0.0125 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0036 | 0.0079 | 1 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Brugia malayi | nuclear receptor NHR-88 | 0.0156 | 0.0468 | 0.0468 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0036 | 0.0079 | 0.0016 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0156 | 0.0468 | 0.0744 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.0048 | 0.0121 | 0.021 |
Loa Loa (eye worm) | tnks protein | 0.0168 | 0.0506 | 0.0506 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0331 | 0.1032 | 0.0961 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0036 | 0.0079 | 0.0138 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0156 | 0.0468 | 0.0468 |
Toxoplasma gondii | hypothetical protein | 0.0036 | 0.0079 | 0.1929 |
Brugia malayi | nuclear receptor NHR-88 | 0.0331 | 0.1032 | 0.1032 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0018 | 0.0032 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0112 | 0.0327 | 0.052 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0112 | 0.0327 | 0.052 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0035 | 0.0078 | 0.0125 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0112 | 0.0327 | 0.7968 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0025 | 0.0025 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.003 | 0.006 | 0.7614 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0175 | 0.0528 | 0.0528 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.013 | 0.0206 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.013 | 0.0384 | 0.0611 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0036 | 0.0079 | 0.0016 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.013 | 0.0384 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.006 | 0.1568 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0018 | 0.0029 |
Schistosoma mansoni | nuclear hormone receptor | 0.0331 | 0.1032 | 0.164 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0175 | 0.0528 | 0.084 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0035 | 0.0078 | 0.191 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0156 | 0.0468 | 0.0744 |
Loa Loa (eye worm) | CYP4Cod1 | 0.003 | 0.006 | 0.006 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0331 | 0.1032 | 0.164 |
Echinococcus multilocularis | H2A histone family, member Y | 0.0036 | 0.0079 | 0.0138 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0018 | 0.0018 |
Entamoeba histolytica | zinc finger protein, putative | 0.0112 | 0.0327 | 0.5093 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0331 | 0.1032 | 0.1802 |
Brugia malayi | conserved hypotetical protein | 0.0156 | 0.0468 | 0.0468 |
Echinococcus granulosus | geminin | 0.018 | 0.0544 | 0.0865 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Onchocerca volvulus | 0.0156 | 0.0468 | 0.0392 | |
Brugia malayi | nuclear receptor RXR | 0.0156 | 0.0468 | 0.0468 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0112 | 0.0327 | 0.052 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0121 | 0.2937 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.034 | 0.034 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0331 | 0.1032 | 0.164 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.0048 | 0.0121 | 0.021 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0331 | 0.1032 | 0.1802 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0018 | 0.0029 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0331 | 0.1032 | 0.1802 |
Echinococcus granulosus | FTZ F1 alpha | 0.0331 | 0.1032 | 0.164 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0035 | 0.0078 | 0.2039 |
Brugia malayi | Probable protein farnesyltransferase beta subunit, putative | 0.0035 | 0.0078 | 0.0078 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0156 | 0.0468 | 0.0744 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0018 | 0.0029 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0156 | 0.0468 | 0.0817 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0048 | 0.0121 | 0.3136 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Schistosoma mansoni | nuclear receptor | 0.0156 | 0.0468 | 0.0744 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0156 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0156 | 0.0468 | 0.0468 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Giardia lamblia | Prenyltransferase | 0.013 | 0.0384 | 0.627 |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0112 | 0.0327 | 0.0571 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.013 | 0.0384 | 1 |
Brugia malayi | Appr-1-p processing enzyme family protein | 0.0036 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0331 | 0.1032 | 0.1032 |
Echinococcus multilocularis | Rab geranylgeranyltransferase, beta subunit | 0.0035 | 0.0078 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0078 | 0.2039 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0048 | 0.0121 | 0.3136 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Trypanosoma brucei | lanosterol synthase | 0.0035 | 0.0078 | 0.2039 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Onchocerca volvulus | Tankyrase homolog | 0.0167 | 0.0502 | 0.0427 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0544 | 0.0865 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0331 | 0.1032 | 0.164 |
Trypanosoma brucei | geranylgeranyl transferase type II beta subunit, putative | 0.0035 | 0.0078 | 0.2039 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0331 | 0.1032 | 0.164 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.3136 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0156 | 0.0468 | 0.0817 |
Onchocerca volvulus | Bile acid receptor homolog | 0.3112 | 1 | 1 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.013 | 0.0384 | 0.0611 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0251 | 0.0774 | 0.1351 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0156 | 0.0468 | 0.0468 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0331 | 0.1032 | 0.1032 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0095 | 0.027 | 0.3936 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0175 | 0.0528 | 0.0923 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0048 | 0.0121 | 0.3136 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0156 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.013 | 0.0384 | 0.627 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.0112 | 0.0327 | 0.0571 |
Brugia malayi | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Brugia malayi | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Onchocerca volvulus | 0.0051 | 0.013 | 0.0051 | |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0018 | 0.0029 |
Schistosoma mansoni | thyroid hormone receptor | 0.0331 | 0.1032 | 0.164 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0018 | 0.0018 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0331 | 0.1032 | 0.1802 |
Loa Loa (eye worm) | DR-78 | 0.0156 | 0.0468 | 0.0468 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1787 | 0.5728 | 1 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.0864 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0187 | 0.0566 | 0.0989 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0331 | 0.1032 | 0.164 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0187 | 0.0566 | 0.09 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1962 | 0.6291 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0331 | 0.1032 | 0.164 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0036 | 0.0079 | 0.0126 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0331 | 0.1032 | 0.164 |
Toxoplasma gondii | Rab geranylgeranyl transferase type II beta subunit, putative | 0.0035 | 0.0078 | 0.191 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0331 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0331 | 0.1032 | 0.1802 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Brugia malayi | steroid hormone receptor | 0.0331 | 0.1032 | 0.1032 |
Onchocerca volvulus | 0.0048 | 0.0121 | 0.0042 | |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0035 | 0.0078 | 0.0137 |
Leishmania major | geranylgeranyltransferase, putative | 0.0035 | 0.0078 | 0.2039 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Onchocerca volvulus | 0.0331 | 0.1032 | 0.0961 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0331 | 0.1032 | 0.1032 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0187 | 0.0566 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0331 | 0.1032 | 0.1802 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.0048 | 0.0121 | 0.0864 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0331 | 0.1032 | 0.164 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.0036 | 0.0079 | 0.2059 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0035 | 0.0078 | 0.0078 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0112 | 0.0327 | 0.8506 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0035 | 0.0078 | 0.2039 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0331 | 0.1032 | 0.1032 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0112 | 0.0327 | 0.0571 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0112 | 0.0327 | 0.5093 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.3136 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0331 | 0.1032 | 0.164 |
Schistosoma mansoni | nuclear receptor | 0.0156 | 0.0468 | 0.0744 |
Brugia malayi | hypothetical protein | 0.0251 | 0.0774 | 0.0774 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0112 | 0.0327 | 0.8506 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0018 | 0.0029 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0331 | 0.1032 | 0.164 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0331 | 0.1032 | 0.1032 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.3136 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0331 | 0.1032 | 0.1032 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0156 | 0.0468 | 0.0744 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0018 | 0.0032 |
Leishmania major | farnesyltransferase beta subunit | 0.013 | 0.0384 | 1 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0048 | 0.0121 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.0774 | 0.0774 |
Schistosoma mansoni | tankyrase | 0.0174 | 0.0527 | 0.0837 |
Trypanosoma brucei | Macro domain containing protein, putative | 0.0036 | 0.0079 | 0.2059 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0035 | 0.0078 | 0.9903 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.013 | 0.0384 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0331 | 0.1032 | 0.164 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.0864 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0187 | 0.0566 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0175 | 0.0528 | 0.084 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0187 | 0.0566 | 0.0566 |
Mycobacterium ulcerans | lipoprotein LppD | 0.0036 | 0.0079 | 1 |
Echinococcus multilocularis | geminin | 0.018 | 0.0544 | 0.095 |
Trypanosoma brucei | cytochrome P450, putative | 0.003 | 0.006 | 0.1568 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0018 | 0.0029 |
Brugia malayi | nuclear hormone receptor | 0.0331 | 0.1032 | 0.1032 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0331 | 0.1032 | 0.164 |
Trichomonas vaginalis | ganglioside induced differentiation associated protein, putative | 0.0036 | 0.0079 | 0.0016 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.0864 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0121 | 0.3136 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0156 | 0.0468 | 0.0468 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0036 | 0.0079 | 0.0016 |
Echinococcus granulosus | tankyrase | 0.0174 | 0.0526 | 0.0836 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0187 | 0.0566 | 0.09 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0327 | 0.5093 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0156 | 0.0468 | 0.0744 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0156 | 0.0468 | 0.0817 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0331 | 0.1032 | 0.164 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0331 | 0.1032 | 0.164 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0135 | 0.0135 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0156 | 0.0468 | 0.0744 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0112 | 0.0327 | 0.052 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0331 | 0.1032 | 0.1032 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.013 | 0.0384 | 0.627 |
Loa Loa (eye worm) | hypothetical protein | 0.3112 | 1 | 1 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.013 | 0.0384 | 0.9367 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.013 | 0.0384 | 0.0384 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0175 | 0.0528 | 0.0528 |
Trypanosoma cruzi | Macro domain containing protein, putative | 0.0036 | 0.0079 | 0.2059 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0187 | 0.0566 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0331 | 0.1032 | 0.1032 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0036 | 0.0079 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0187 | 0.0566 | 0.0566 |
Schistosoma mansoni | geranylgeranyl transferase type II beta subunit | 0.0035 | 0.0078 | 0.0125 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.013 | 0.0384 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0078 | 0.0078 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0187 | 0.0566 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0156 | 0.0468 | 0.0744 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0035 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0048 | 0.0121 | 0.0192 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0156 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0018 | 0.0032 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0468 | 0.0468 |
Schistosoma mansoni | nuclear hormone receptor | 0.0156 | 0.0468 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0078 | 0.0078 |
Brugia malayi | WGR domain containing protein | 0.0116 | 0.034 | 0.034 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0331 | 0.1032 | 0.1032 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0156 | 0.0468 | 0.0744 |
Leishmania major | cytochrome p450-like protein | 0.003 | 0.006 | 0.1568 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0078 | 0.2039 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0079 | 0.0126 |
Echinococcus granulosus | H2A histone family member Y | 0.0036 | 0.0079 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1032 | 0.1032 |
Toxoplasma gondii | hypothetical protein | 0.0138 | 0.041 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0331 | 0.1032 | 0.1032 |
Brugia malayi | ecdysone receptor | 0.0156 | 0.0468 | 0.0468 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0156 | 0.0468 | 0.0392 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0112 | 0.0327 | 0.8506 |
Trypanosoma cruzi | geranylgeranyl transferase type II beta subunit, putative | 0.0035 | 0.0078 | 0.2039 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0331 | 0.1032 | 0.1032 |
Giardia lamblia | Protein LRP16 | 0.0036 | 0.0079 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0079 | 0.0126 |
Brugia malayi | WGR domain containing protein | 0.0112 | 0.0327 | 0.0327 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0156 | 0.0468 | 0.0817 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0048 | 0.0121 | 0.3136 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.014 | 0.014 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0081 | 0.0081 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0331 | 0.1032 | 0.1802 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0187 | 0.0566 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0018 | 0.0029 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.0048 | 0.0121 | 0.0192 |
Brugia malayi | nuclear receptor NHR-67 | 0.0156 | 0.0468 | 0.0468 |
Mycobacterium leprae | putative cytochrome p450 | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0138 | 0.041 | 0.6802 |
Brugia malayi | nuclear receptor RXR | 0.0175 | 0.0528 | 0.0528 |
Brugia malayi | nuclear hormone receptor | 0.0156 | 0.0468 | 0.0468 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0036 | 0.0079 | 0.0016 |
Mycobacterium tuberculosis | Possible lipoprotein LppD | 0.0036 | 0.0079 | 1 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0187 | 0.0566 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0331 | 0.1032 | 0.1032 |
Plasmodium falciparum | Appr-1-p processing domain protein | 0.0036 | 0.0079 | 0.0016 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0156 | 0.0468 | 0.0817 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0079 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0018 | 0.0018 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0331 | 0.1032 | 0.1032 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0048 | 0.0121 | 0.3136 |
Brugia malayi | Tnks protein | 0.0173 | 0.0523 | 0.0523 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0566 | 0.0566 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0175 | 0.0528 | 0.084 |
Giardia lamblia | Phosphatase similar to the C-terminal domain of histone macroH2A1 | 0.0036 | 0.0079 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0081 | 0.0129 |
Brugia malayi | hypothetical protein | 0.0175 | 0.0528 | 0.0528 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0035 | 0.0078 | 0.0125 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0175 | 0.0528 | 0.0528 |
Onchocerca volvulus | 0.0156 | 0.0468 | 0.0392 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 96 % | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 250 ug/ml after 12 to 28 days by Lowenstein-Jensen method relative to control | ChEMBL. | 23747804 |
MIC (functional) | = 100 ug ml-1 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 12 to 28 days by Lowenstein-Jensen method | ChEMBL. | 23747804 |
MIC (functional) | = 250 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition by broth microdilution method | ChEMBL. | 23747804 |
MIC (functional) | = 500 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition by broth microdilution method | ChEMBL. | 23747804 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.