Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0258 | 0.9706 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0263 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0155 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0258 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0155 | 0.2852 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.2852 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0263 | 1 | 1 |
Onchocerca volvulus | 0.0263 | 1 | 0.5 | |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0258 | 0.9706 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0263 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0263 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0155 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0263 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0258 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.9706 | 0.9604 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0263 | 1 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0155 | 0.2852 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 14 uM | Cytotoxicity against human HEL cells after 72 hrs by plate reader analysis | ChEMBL. | 23567961 |
Inhibition (binding) | Inhibition of IGF1R (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of TYRO3 (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of EPHA5 (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of FLT3 phosphorylation in mouse Ba/F3 cells transfected with FLT3-ITD cells at 500 nM after 90 mins by Western blot analysis | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of AXL (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of SRC (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of FYN (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of NTRK3 (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of EPHA2 (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of EGFR (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of MATK1 (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of HCK (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of SYK (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of MERTK (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of EPHA1 (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of FGFR3 (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of TNK1 (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 | |
Inhibition (binding) | Inhibition of YES (unknown origin) transfected in mouse Ba/F3 cells at 5 uM after 24 hrs | ChEMBL. | 23567961 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23567961 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.