Detailed information for compound 1781159

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.462 | Formula: C23H25N3O4
  • H donors: 2 H acceptors: 3 LogP: 2.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)/C=C/c1ccc2c(c1)C(=O)N(C1(O2)CCN(CC1)C)Cc1ccccc1
  • InChi: 1S/C23H25N3O4/c1-25-13-11-23(12-14-25)26(16-18-5-3-2-4-6-18)22(28)19-15-17(7-9-20(19)30-23)8-10-21(27)24-29/h2-10,15,29H,11-14,16H2,1H3,(H,24,27)/b10-8+
  • InChiKey: KHLXXXDFKJAZBV-CSKARUKUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0128 0.0302
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0307 0.0984
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0054 0.0349 0.0647
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1467 0.6754
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0102 0.0242
Loa Loa (eye worm) cyclin C 0.0013 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0106 0.0794 0.1473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0053 0.0339 0.0629
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0102 0.0242
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Brugia malayi Protein kinase domain containing protein 0.0015 0.0017 0.004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0309 0.1407
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0219 0.1754 0.2445
Loa Loa (eye worm) hypothetical protein 0.0065 0.044 0.0816
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Trichomonas vaginalis AGC family protein kinase 0.0116 0.088 0.4043
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0021 0.0071 0.0132
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0086 0.0621 0.1145
Brugia malayi Protein kinase domain containing protein 0.002 0.0057 0.0136
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.016 0.1256 0.4058
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0098 0.0723 0.1341
Onchocerca volvulus 0.0054 0.0349 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0023 0.009
Entamoeba histolytica protein kinase, putative 0.0034 0.0178 0.0984
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.1043 0.1929
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0025 0.004
Trypanosoma brucei histone deacetylase 4 0.0051 0.0325 0.1042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0171
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.027 0.0494
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0026 0.0119
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0015 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.1043 0.1935
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0015 0.0016
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0054 0.0349 0.0482
Echinococcus granulosus somatostatin receptor 0.0054 0.0349 0.064
Brugia malayi serine/threonine kinase 12 0.0116 0.088 0.2082
Plasmodium falciparum protein kinase 5 0.0049 0.0307 0.3467
Entamoeba histolytica PH domain containing protein kinase, putative 0.011 0.0826 0.4631
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Entamoeba histolytica protein kinase, putative 0.0024 0.0092 0.0495
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0441 0.0611
Echinococcus multilocularis aurora kinase A 0.0116 0.088 0.1224
Trypanosoma brucei aurora B kinase 0.0116 0.088 0.2839
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0005 0.0003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0026 0.0155
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0171 0.1345 0.1875
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0053 0.0339 0.0795
Echinococcus multilocularis neuropeptide FF receptor 2 0.0054 0.0349 0.0482
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0036 0.0201 0.0476
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0056 0.0287
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0359 0.0496
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0026 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0102 0.0183
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0056 0.0602
Loa Loa (eye worm) hypothetical protein 0.0111 0.0837 0.1552
Brugia malayi Protein kinase domain containing protein 0.0015 0.0017 0.004
Echinococcus multilocularis geminin 0.0165 0.1293 0.1801
Mycobacterium tuberculosis Conserved protein 0.0186 0.1473 0.1451
Loa Loa (eye worm) pyruvate kinase 0.0034 0.018 0.0334
Brugia malayi serine/threonine-protein kinase 6 0.0116 0.088 0.2082
Leishmania major protein kinase, putative 0.002 0.0065 0.0199
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0116 0.088 0.4935
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0282 0.1895
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0055 0.0359 0.0496
Giardia lamblia Hypothetical protein 0.0222 0.1779 1
Onchocerca volvulus 0.0054 0.0349 0.0817
Trichomonas vaginalis AGC family protein kinase 0.0109 0.0815 0.3742
Schistosoma mansoni atypical protein kinase C 0.0096 0.0708 0.1307
Onchocerca volvulus 0.0013 0.0005 0.0004
Onchocerca volvulus 0.0054 0.0349 0.0817
Loa Loa (eye worm) hypothetical protein 0.0053 0.0339 0.0629
Onchocerca volvulus 0.005 0.032 0.0748
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1869 0.3463
Brugia malayi p70 ribosomal S6 kinase beta 0.0189 0.1496 0.354
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0021 0.0074 0.0137
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0378 0.0523
Schistosoma mansoni protein kinase 0.0219 0.1754 0.3248
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0054 0.0349 0.064
Schistosoma mansoni coup transcription factor 0.0053 0.0339 0.0623
Schistosoma mansoni biogenic amine receptor 0.0054 0.0349 0.064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0015 0.0037
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0056 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0227 0.0421
Schistosoma mansoni protein kinase 0.0021 0.0074 0.013
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0056 0.0297
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0028 0.0128 0.0402
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0349 0.0482
Echinococcus granulosus cyclin dependent kinase 1 0.0049 0.0307 0.0564
Trichomonas vaginalis penicillin-binding protein, putative 0.0186 0.1473 0.6781
Echinococcus granulosus pyruvate kinase 0.0034 0.018 0.0327
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0053 0.0339 0.0623
Loa Loa (eye worm) hypothetical protein 0.0052 0.0331 0.0614
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0026 0.0063
Onchocerca volvulus 0.0083 0.0594 0.1398
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus granulosus g protein coupled receptor 0.0054 0.0349 0.064
Entamoeba histolytica cyclin, putative 0.0055 0.0358 0.1997
Entamoeba histolytica protein kinase, putative 0.0191 0.1514 0.8506
Trichomonas vaginalis STE family protein kinase 0.0021 0.0074 0.0323
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0013 0.0005 0.0013
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0054 0.0349 0.064
Onchocerca volvulus 0.002 0.0065 0.0145
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0053 0.0339 0.0623
Brugia malayi Protein kinase domain containing protein 0.0265 0.2148 0.5083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0349 0.064
Schistosoma mansoni zinc finger protein 0.0025 0.0102 0.0183
Brugia malayi photoreceptor-specific nuclear receptor 0.0053 0.0339 0.0803
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0086 0.0621 0.1145
Onchocerca volvulus 0.0015 0.0017 0.0032
Brugia malayi Cyclin C 0.0013 0.0004 0.0009
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0017 0.0032 0.0052
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0325 0.1042
Loa Loa (eye worm) hypothetical protein 0.0083 0.0594 0.1102
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0237
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.0339 0.0803
Onchocerca volvulus 0.0025 0.0102 0.0234
Brugia malayi RhoGAP domain containing protein 0.0021 0.0069 0.0164
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0349 0.0482
Echinococcus granulosus 7TM GPCR rhodopsin 0.0054 0.0349 0.064
Leishmania major pyruvate kinase 0.0034 0.018 0.0571
Echinococcus granulosus tyrosine kinase 0.0044 0.027 0.0494
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0307 0.1711
Loa Loa (eye worm) hypothetical protein 0.0106 0.0794 0.1473
Echinococcus granulosus tyrosine kinase 0.0015 0.0017 0.0025
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0054 0.0349 0.0825
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0309 0.1407
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.0349 0.064
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Brugia malayi C1-like domain containing protein 0.0098 0.0723 0.1711
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0004 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.021 0.0289
Loa Loa (eye worm) TK protein kinase 0.0034 0.0178 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.002 0.003
Brugia malayi Doublecortin family protein 0.002 0.0065 0.0154
Loa Loa (eye worm) hypothetical protein 0.0186 0.1473 0.2733
Echinococcus granulosus neuropeptide receptor A26 0.0054 0.0349 0.064
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0065 0.0417
Onchocerca volvulus 0.0054 0.0349 0.0817
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.018 0.0417
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0021 0.0071 0.0132
Echinococcus granulosus inositol monophosphatase 1 0.004 0.023 0.042
Onchocerca volvulus 0.0054 0.0349 0.0817
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus granulosus alpha 1A adrenergic receptor 0.0054 0.0349 0.064
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0049 0.0307 0.0984
Entamoeba histolytica hypothetical protein 0.0109 0.0821 0.4607
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0325 0.0449
Brugia malayi hypothetical protein 0.0036 0.0201 0.0476
Brugia malayi G protein-coupled receptor 0.0054 0.0349 0.0825
Trypanosoma brucei histone deacetylase 3 0.0051 0.0325 0.1042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0349 0.064
Brugia malayi ribosomal protein S6 kinase alpha 3 0.009 0.0657 0.1556
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0128 0.023
Echinococcus granulosus geminin 0.0165 0.1293 0.2393
Trichomonas vaginalis cyclins, putative 0.0106 0.0794 0.3648
Echinococcus granulosus c src tyrosine kinase 0.0025 0.0106 0.019
Brugia malayi nuclear receptor NHR-88 0.0025 0.0102 0.0242
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0359 0.0496
Trichomonas vaginalis cyclins, putative 0.0055 0.0358 0.1636
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0013 0.0005 0.0002
Echinococcus granulosus cyclins 0.0055 0.0358 0.0658
Brugia malayi Tyrosine-protein kinase abl-1 0.0106 0.0789 0.1868
Brugia malayi tailless protein 0.0025 0.0102 0.0242
Echinococcus multilocularis ecdysone induced protein 78C 0.0053 0.0339 0.0469
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0026 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0339 0.0803
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0005 0.0003
Echinococcus granulosus neuropeptide receptor 0.0054 0.0349 0.064
Trypanosoma cruzi cyclin, putative 0.0106 0.0794 0.2561
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.018 0.1081
Loa Loa (eye worm) histone deacetylase 7A 0.0051 0.0325 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0156 0.0282
Mycobacterium ulcerans pyruvate kinase 0.0034 0.018 0.0984
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.0349 0.064
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0044 0.0269 0.037
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0056 0.0243
Trypanosoma brucei unspecified product 0.0027 0.0122 0.0384
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0015 0.0016
Brugia malayi putative neuropeptide receptor 0.0054 0.0349 0.0825
Schistosoma mansoni tyrosine kinase 0.0214 0.1713 0.3172
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus granulosus protein kinase c epsilon type 0.0096 0.0708 0.1307
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Echinococcus multilocularis transmembrane protease serine 3 0.0013 0.0005 0.0002
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0349 0.0482
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0043 0.0259 0.0474
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0226 0.0413
Echinococcus multilocularis RUN 0.002 0.0065 0.0086
Entamoeba histolytica protein kinase, putative 0.0116 0.088 0.4935
Brugia malayi Tachykinin-like peptides receptor 99D 0.0054 0.0349 0.0825
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0026 0.0074
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0096 0.0708 0.1313
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0441 0.0611
Schistosoma mansoni serine/threonine-protein kinase 0.011 0.0826 0.1526
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0056 0.1471
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0023 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0349 0.064
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.018 0.0813
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0056 0.0171
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0065 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Onchocerca volvulus 0.0054 0.0349 0.0817
Echinococcus multilocularis protein tyrosine kinase 0.0262 0.2122 0.296
Brugia malayi Protein kinase domain containing protein 0.0191 0.1514 0.3582
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Onchocerca volvulus Huntingtin homolog 0.0509 0.4225 1
Echinococcus multilocularis neuropeptide s receptor 0.0054 0.0349 0.0482
Trichomonas vaginalis AGC family protein kinase 0.0191 0.1514 0.6968
Schistosoma mansoni protein kinase 0.0219 0.1754 0.3248
Echinococcus multilocularis sex peptide receptor 0.0054 0.0349 0.0482
Loa Loa (eye worm) CYL-1 protein 0.0013 0.0004 0.0007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0005 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0053 0.0339 0.0803
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0026 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Echinococcus multilocularis tyrosine protein kinase Abl 0.0106 0.0789 0.1098
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0226 0.0311
Loa Loa (eye worm) AUR protein kinase 0.0116 0.088 0.1632
Onchocerca volvulus 0.0053 0.0339 0.0795
Schistosoma mansoni protein kinase 0.0044 0.0269 0.0492
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0529 0.0975
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0376 0.309 1
Schistosoma mansoni protein kinase C mu 0.0098 0.0723 0.1335
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0349 0.064
Loa Loa (eye worm) hypothetical protein 0.0084 0.0609 0.1129
Giardia lamblia Hypothetical protein 0.0055 0.0358 0.1997
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Chlamydia trachomatis pyruvate kinase 0.0034 0.018 1
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0128 0.023
Brugia malayi G protein-coupled receptor F59B2.13 0.0054 0.0349 0.0825
Trypanosoma brucei unspecified product 0.0039 0.0226 0.0722
Loa Loa (eye worm) hypothetical protein 0.0186 0.1473 0.2733
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0226 0.1028
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.002 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.1629 0.3021
Loa Loa (eye worm) AUR protein kinase 0.0116 0.088 0.1632
Brugia malayi larval opioid receptor 0.0054 0.0349 0.0825
Entamoeba histolytica protein kinase 2, putative 0.0108 0.0808 0.4531
Onchocerca volvulus 0.0015 0.0022 0.0043
Loa Loa (eye worm) hypothetical protein 0.0053 0.0339 0.0629
Entamoeba histolytica PH domain containing protein kinase, putative 0.011 0.0826 0.4631
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0349 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0025 0.003
Echinococcus multilocularis somatostatin receptor 0.0054 0.0349 0.0482
Entamoeba histolytica protein kinase, putative 0.0021 0.0074 0.0395
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0026 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2171 1
Onchocerca volvulus 0.0015 0.0017 0.0032
Echinococcus granulosus cyclin dependent kinase 5 0.0049 0.0307 0.0564
Giardia lamblia Cyclin A 0.0055 0.0358 0.1997
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Trichomonas vaginalis AGC family protein kinase 0.0116 0.088 0.4043
Plasmodium vivax histone deacetylase 2, putative 0.0051 0.0325 0.2188
Schistosoma mansoni tyrosine kinase 0.0021 0.0067 0.0117
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.0376 0.309 0.5728
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0349 0.0482
Trichomonas vaginalis AGC family protein kinase 0.0116 0.088 0.4043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0339 0.0803
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0053 0.0339 0.0803
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0054 0.0349 0.0825
Brugia malayi Dopamine receptor protein 2 0.0054 0.0349 0.0825
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Brugia malayi protein kinase C II. 0.0096 0.0708 0.1676
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0349 0.0482
Trichomonas vaginalis AGC family protein kinase 0.0191 0.1514 0.6968
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0054 0.0349 0.064
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0054 0.0349 0.064
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0349 0.064
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0021 0.0069 0.0122
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0086 0.0621 0.0862
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0056 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0339 0.0803
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0349 0.064
Entamoeba histolytica hypothetical protein 0.0049 0.0309 0.1718
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0708 0.1307
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0282 0.0517
Echinococcus multilocularis enteropeptidase 0.0013 0.0005 0.0002
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0108 0.0808 0.5473
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0054 0.0349 0.0825
Echinococcus multilocularis histone deacetylase 0.0051 0.0325 0.0449
Loa Loa (eye worm) hypothetical protein 0.0509 0.4225 0.7837
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0025 0.0106 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.024 0.0438
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0349 0.0482
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0004 0.0009
Onchocerca volvulus 0.0186 0.1473 0.3481
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0349 0.064
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0376 0.309 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0359 0.0659
Echinococcus granulosus FTZ F1 alpha 0.0053 0.0339 0.0623
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0053 0.0339 0.0623
Echinococcus granulosus protein tyrosine kinase 0.0262 0.2122 0.3931
Plasmodium falciparum thioredoxin reductase 0.0016 0.0026 0.026
Entamoeba histolytica p21-activated kinase 0.0046 0.0287 0.1593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0349 0.064
Onchocerca volvulus 0.0054 0.0349 0.0817
Giardia lamblia Kinase, AGC AKT 0.009 0.0657 0.3682
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0026 0.0105
Entamoeba histolytica Ran family GTPase 0.0045 0.027 0.1501
Echinococcus multilocularis protein kinase c iota type 0.0096 0.0708 0.0984
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0349 0.064
Schistosoma mansoni histone deacetylase hda2 0.0051 0.0325 0.0597
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0186 0.1473 0.1451
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0102 0.0183
Brugia malayi RE15519p 0.0054 0.0349 0.0825
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Echinococcus multilocularis snurportin 1 0.0646 0.5391 0.7528
Brugia malayi P21-Rho-binding domain containing protein 0.0017 0.0032 0.0076
Echinococcus granulosus serine:threonine protein kinase N2 0.0086 0.0621 0.1145
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.027 0.0372
Trichomonas vaginalis cyclin B, putative 0.0106 0.0794 0.3648
Schistosoma mansoni tyrosine kinase 0.0015 0.0017 0.0025
Loa Loa (eye worm) hypothetical protein 0.0369 0.3036 0.5631
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0054 0.0349 0.0817
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0349 0.064
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0053 0.0339 0.0803
Schistosoma mansoni cyclin B 0.0106 0.0794 0.1467
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0189 0.1496 0.2775
Entamoeba histolytica protein kinase, putative 0.0086 0.0621 0.3476
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0339 0.0469
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0017 0.0032
Schistosoma mansoni polycystin 1-related 0.002 0.0065 0.0114
Loa Loa (eye worm) hypothetical protein 0.0214 0.1712 0.3175
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0222 0.1779 1
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1473 0.6781
Brugia malayi Dopamine receptor 0.0054 0.0349 0.0825
Echinococcus multilocularis pyruvate kinase 0.0027 0.0119 0.0161
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0349 0.0482
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus granulosus G protein coupled receptor 139 0.0054 0.0349 0.064
Onchocerca volvulus 0.0376 0.309 0.731
Loa Loa (eye worm) hypothetical protein 0.0036 0.0199 0.0369
Echinococcus granulosus neuropeptide FF receptor 2 0.0054 0.0349 0.064
Toxoplasma gondii histone deacetylase HDAC1 0.0051 0.0325 0.2155
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0054 0.0349 0.064
Brugia malayi hypothetical protein 0.0054 0.0349 0.0825
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0043 0.0259 0.0357
Loa Loa (eye worm) hypothetical protein 0.0509 0.4225 0.7837
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.001
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0116 0.088 0.4935
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0235 0.0323
Leishmania major cyclin 0.0106 0.0794 0.2561
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0116 0.088 0.1626
Echinococcus multilocularis cyclins 0.0055 0.0358 0.0495
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0349 0.064
Brugia malayi Protein kinase domain 0.0044 0.0269 0.0636
Plasmodium falciparum serine/threonine protein kinase, putative 0.0116 0.088 1
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Entamoeba histolytica protein kinase , putative 0.0116 0.088 0.4935
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0235 0.0429
Schistosoma mansoni lipoxygenase 0.002 0.0065 0.0114
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0102 0.019
Echinococcus granulosus protein kinase C gamma type 0.0086 0.0621 0.1145
Echinococcus granulosus cyclin dependent kinase 0.0049 0.0307 0.0564
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0026 0.0032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0053 0.0339 0.0803
Brugia malayi hypothetical protein 0.0054 0.0349 0.0825
Mycobacterium tuberculosis Conserved protein 0.0186 0.1473 0.1451
Schistosoma mansoni opsin-like receptor 0.0054 0.0349 0.064
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Loa Loa (eye worm) TK/ABL protein kinase 0.0225 0.1804 0.3346
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0005 0.0003
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0065 0.0086
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0036 0.0201 0.0367
Onchocerca volvulus Neuropeptide F receptor homolog 0.0054 0.0349 0.0817
Giardia lamblia Pyruvate kinase 0.0034 0.018 0.0992
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.0339 0.0623
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0015 0.0029
Echinococcus granulosus cyclins 0.0055 0.0358 0.0658
Schistosoma mansoni intermediate filament proteins 0.0113 0.0854 0.1579
Echinococcus granulosus pyruvate kinase 0.0017 0.0039 0.0066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.1629 0.3854
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0122 0.0384
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus granulosus orexin receptor type 2 0.0054 0.0349 0.064
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.0349 0.064
Schistosoma mansoni opsin-like receptor 0.0054 0.0349 0.064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0441 0.1043
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Loa Loa (eye worm) doublecortin family protein 0.002 0.0065 0.0121
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0128 0.023
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.0023 0.009
Brugia malayi nuclear receptor NHR-67 0.0025 0.0102 0.0242
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0023 0.009
Schistosoma mansoni single-minded 0.0016 0.0023 0.0036
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0282 0.0902
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0092 0.05
Plasmodium falciparum pyruvate kinase 0.0034 0.018 0.2011
Giardia lamblia G2/mitotic-specific cyclin B 0.0106 0.0794 0.4453
Brugia malayi GnHR receptor homolog 0.0054 0.0349 0.0825
Schistosoma mansoni hypothetical protein 0.0165 0.1293 0.2393
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0056 0.0297
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0307 0.0984
Schistosoma mansoni ran 0.0045 0.027 0.0495
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.023 0.0733
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0071 0.0169
Brugia malayi cell division control protein 2 homolog 0.0049 0.0307 0.0728
Trypanosoma cruzi CYC2-like cyclin, putative 0.0106 0.0794 0.2561
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.027 0.0494
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0054 0.0349 0.0482
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.023 0.0733
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0055 0.0359 0.0496
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0026 0.0109 0.0485
Onchocerca volvulus 0.0013 0.0005 0.0004
Echinococcus granulosus histone deacetylase 6 0.0051 0.0325 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0053 0.0339 0.0629
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0108 0.0808 0.1493
Entamoeba histolytica cyclin, putative 0.0106 0.0794 0.4453
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1387 0.6382
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Mycobacterium tuberculosis Probable reductase 0.0105 0.0783 0.0759
Echinococcus granulosus ecdysone induced protein 78C 0.0053 0.0339 0.0623
Brugia malayi Protein kinase domain containing protein 0.0015 0.0017 0.004
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0349 0.0482
Schistosoma mansoni hypothetical protein 0.0054 0.0349 0.064
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.027 0.0372
Loa Loa (eye worm) steroid hormone receptor 0.0053 0.0339 0.0629
Echinococcus granulosus nervana 2 0.0103 0.0766 0.1415
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0821 0.1518
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0049 0.0307 0.2035
Onchocerca volvulus 0.0054 0.0349 0.0817
Echinococcus multilocularis pyruvate kinase 0.0017 0.0039 0.005
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0004 0.0007
Schistosoma mansoni loxhd1 0.002 0.0065 0.0114
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Loa Loa (eye worm) hypothetical protein 0.0093 0.0681 0.1264
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0226 0.0722
Entamoeba histolytica protein kinase, putative 0.0043 0.0259 0.1439
Brugia malayi Protein kinase domain containing protein 0.0175 0.1378 0.3262
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0028 0.0128 0.0237
Plasmodium falciparum thioredoxin reductase 0.0046 0.0282 0.3178
Echinococcus granulosus death domain containing protein 0.0015 0.0015 0.0022
Schistosoma mansoni lamin 0.0113 0.0854 0.1579
Echinococcus multilocularis protein kinase c epsilon type 0.0096 0.0708 0.0984
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0349 0.064
Echinococcus granulosus PAK box P21 Rho binding 0.0017 0.0032 0.0052
Trichomonas vaginalis cyclin B, putative 0.0106 0.0794 0.3648
Brugia malayi Inositol-1 0.004 0.023 0.0544
Brugia malayi SH2 domain containing protein 0.0015 0.0017 0.004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0026 0.0119
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0307 0.1402
Schistosoma mansoni nck2/grb4 0.0021 0.0071 0.0125
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0053 0.0339 0.0623
Schistosoma mansoni tyrosine kinase 0.0015 0.0018 0.0027
Onchocerca volvulus 0.0186 0.1473 0.3481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1043 0.1929
Brugia malayi hypothetical protein 0.0013 0.0004 0.0009
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0025 0.0106 0.019
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0186 0.1473 0.1451
Echinococcus granulosus GPCR family 2 0.0065 0.0441 0.0811
Loa Loa (eye worm) hypothetical protein 0.0083 0.0594 0.1102
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.023 0.1044
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0017 0.0032
Loa Loa (eye worm) cyclin domain-containing protein 0.017 0.1335 0.2476
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0013 0.0017
Schistosoma mansoni tyrosine kinase 0.0055 0.0359 0.0659
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0028 0.0127 0.0567
Trichomonas vaginalis STE family protein kinase 0.0044 0.0269 0.1223
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0121
Loa Loa (eye worm) hypothetical protein 0.0232 0.1869 0.3467
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0013 0.0005 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1387 0.6382
Schistosoma mansoni neuropeptide receptor 0.0054 0.0349 0.064
Trichomonas vaginalis AGC family protein kinase 0.0191 0.1514 0.6968
Leishmania major protein kinase, putative 0.0025 0.0107 0.0335
Echinococcus granulosus tachykinin peptides receptor 99D 0.0054 0.0349 0.064
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Plasmodium falciparum histone deacetylase, putative 0.0051 0.0325 0.367
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1473 0.6781
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.027 0.3041
Onchocerca volvulus 0.0054 0.0349 0.0817
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0349 0.0482
Trypanosoma brucei cdc2-related kinase 1 0.0049 0.0307 0.0984
Echinococcus multilocularis histone deacetylase 7 0.0051 0.0325 0.0449
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0004 0.0007
Echinococcus multilocularis dna polymerase eta 0.0039 0.0226 0.0311
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0026 0.0109 0.0485
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0226 0.0311
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0028 0.0128 0.0302
Trypanosoma brucei mitotic cyclin 6 0.0106 0.0794 0.2561
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1869 0.2607
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0307 0.0424
Echinococcus granulosus beta LACTamase domain containing family member 0.0186 0.1473 0.2728
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0004 0.0009
Echinococcus multilocularis cyclin b3 0.0055 0.0358 0.0495
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.027 0.0863
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0054 0.0349 0.064
Loa Loa (eye worm) hypothetical protein 0.0051 0.0327 0.0606
Brugia malayi Serotonin receptor 0.0054 0.0349 0.0825
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0015 0.0022
Brugia malayi hypothetical protein 0.0036 0.0199 0.0471
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0004 0.0007
Echinococcus multilocularis muscleblind protein 1 0.0153 0.1194 0.1664
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0122 0.0384
Brugia malayi protein kinase C3,putative 0.0015 0.002 0.0047
Plasmodium falciparum histone deacetylase 2 0.0051 0.0325 0.367
Onchocerca volvulus 0.0013 0.0005 0.0004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0053 0.0339 0.0623
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0023 0.009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.1043 0.2468
Brugia malayi nuclear hormone receptor 0.0025 0.0102 0.0242
Echinococcus granulosus N chimaerin 0.0021 0.0069 0.0122
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0005 0.0003
Echinococcus multilocularis nervana 2 0.0103 0.0766 0.1065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0339 0.0623
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0226 0.0722
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.018 0.0571
Mycobacterium ulcerans hypothetical protein 0.0186 0.1473 0.8276
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.002 0.0065 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0053 0.0339 0.0629
Trichomonas vaginalis cyclins, putative 0.0106 0.0794 0.3648
Onchocerca volvulus Huntingtin homolog 0.0509 0.4225 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0053 0.0339 0.0623
Echinococcus multilocularis N chimaerin 0.0021 0.0069 0.0092
Brugia malayi serine/threonine protein kinase 6 0.0116 0.088 0.2082
Echinococcus multilocularis pyruvate kinase 0.0034 0.018 0.0246
Entamoeba histolytica cyclin family protein 0.0055 0.0358 0.1997
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0017 0.0032
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0026 0.0119
Echinococcus multilocularis pyruvate kinase 0.0034 0.018 0.0246
Brugia malayi nuclear receptor RXR 0.0028 0.0128 0.0302
Onchocerca volvulus 0.0054 0.0349 0.0817
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.0074
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0065 0.0114
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.0349 0.0647
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.2171 0.4026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0349 0.0482
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0102 0.0183
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.002 0.0065 0.0199
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0055 0.0359 0.0496
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0783 0.0759
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0004 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0191 0.1514 0.6968
Giardia lamblia Pyruvate kinase 0.0017 0.0039 0.02
Schistosoma mansoni nuclear receptor 0.0025 0.0102 0.0183
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0017 0.0032
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0026 0.0074
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.018 0.0571
Trypanosoma brucei pyruvate kinase 1 0.0034 0.018 0.0571
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0056 0.0105
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0307 0.0424
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0015 0.002 0.0023
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0049 0.0307 0.057
Echinococcus multilocularis cyclins 0.0055 0.0358 0.0495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0349 0.064
Echinococcus multilocularis Glutaredoxin protein 5 0.0103 0.0766 0.1065
Echinococcus granulosus raf serine:threonine protein kinase 0.0014 0.0013 0.0017
Brugia malayi PAS domain containing protein 0.0016 0.0023 0.0055
Schistosoma mansoni adenoreceptor 0.0054 0.0349 0.064
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0039 0.0406
Leishmania major GTP-binding protein, putative 0.0045 0.027 0.0863
Brugia malayi WH1 domain containing protein 0.0017 0.0032 0.0076
Entamoeba histolytica protein kinase, putative 0.0189 0.1496 0.8406
Echinococcus granulosus Ankyrin 0.0015 0.0017 0.0024
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.018 0.0154
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.1079 0.2553
Entamoeba histolytica protein kinase, putative 0.0191 0.1514 0.8506
Echinococcus multilocularis serine:threonine protein kinase N2 0.0086 0.0621 0.0862
Echinococcus multilocularis serine threonine protein kinase 0.0086 0.0621 0.0862
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.1043 0.1452
Giardia lamblia DINP protein human, muc B family 0.0039 0.0226 0.1255
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0307 0.1402
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0004 0.0007
Brugia malayi ecdysteroid receptor 0.0053 0.0339 0.0803
Brugia malayi steroid hormone receptor 0.0053 0.0339 0.0803
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0237
Schistosoma mansoni opsin-like receptor 0.0054 0.0349 0.064
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0621 0.1145
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0005 0.0002
Loa Loa (eye worm) inositol-1 0.004 0.023 0.0426
Mycobacterium tuberculosis Probable hydrolase 0.0186 0.1473 0.1451
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0053 0.0339 0.0623
Plasmodium vivax histone deacetylase, putative 0.0051 0.0325 0.2188
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0378 0.0695
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0349 0.064
Echinococcus granulosus serine/threonine protein kinase 0.011 0.0826 0.1526
Schistosoma mansoni hypothetical protein 0.0054 0.0349 0.064
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.1387 0.3276
Leishmania major hypothetical protein, conserved 0.0186 0.1473 0.4762
Brugia malayi Melatonin receptor type 1A 0.0054 0.0349 0.0825
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0065 0.0086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0031
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0376 0.309 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.027 0.1813
Trichomonas vaginalis cyclins, putative 0.0106 0.0794 0.3648
Mycobacterium ulcerans beta-lactamase 0.0186 0.1473 0.8276
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Loa Loa (eye worm) hypothetical protein 0.0186 0.1473 0.2733
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0102 0.0138
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0055 0.0356 0.0492
Trichomonas vaginalis esterase, putative 0.0186 0.1473 0.6781
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0017 0.0032 0.0039
Entamoeba histolytica protein kinase, putative 0.0044 0.0269 0.1493
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1043 0.1929
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.0074
Trypanosoma brucei cdc2-related kinase 3 0.0049 0.0307 0.0984
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0004 0.0007
Schistosoma mansoni neuropeptide f receptor 76f 0.0054 0.0349 0.064
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0406 0.0562
Echinococcus granulosus tyrosine protein kinase shark 0.0015 0.0018 0.0027
Echinococcus granulosus pyruvate kinase 0.0034 0.018 0.0327
Leishmania major protein kinase, putative 0.0116 0.088 0.2839
Echinococcus granulosus enteropeptidase 0.0013 0.0005 0.0003
Echinococcus granulosus transmembrane protease serine 3 0.0013 0.0005 0.0003
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0307 0.1711
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0013 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Plasmodium vivax protein kinase Crk2 0.0049 0.0307 0.2067
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0349 0.0482
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Schistosoma mansoni hypothetical protein 0.0065 0.0441 0.0811
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.024 0.0438
Loa Loa (eye worm) SRC-1 0.0055 0.0359 0.0665
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.0023 0.009
Echinococcus multilocularis FTZ F1 alpha 0.0053 0.0339 0.0469
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.018 0.0417
Plasmodium vivax importin-beta 2, putative 0.0061 0.0406 0.2739
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0621 0.1145
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.0132
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.0376 0.309 0.4312
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.027 0.0639
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Toxoplasma gondii thioredoxin reductase 0.0046 0.0282 0.1866
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0879 0.163
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Brugia malayi Sex muscle abnormal protein 5 0.0021 0.0071 0.0169
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0226 0.0722
Plasmodium falciparum cyclin 0.0055 0.0358 0.4047
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0783 0.0759
Trichomonas vaginalis STE family protein kinase 0.0044 0.0269 0.1223
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0026 0.0153
Leishmania major histone deacetylase, putative 0.0051 0.0325 0.1042
Brugia malayi hypothetical protein 0.0013 0.0004 0.0009
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0226 0.1028
Onchocerca volvulus 0.0015 0.0017 0.0032
Brugia malayi hypothetical protein 0.0015 0.0017 0.004
Schistosoma mansoni hypothetical protein 0.0646 0.5391 1
Trichomonas vaginalis cyclin B, putative 0.0055 0.0358 0.1636
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0032
Onchocerca volvulus Bile acid receptor homolog 0.0053 0.0339 0.0795
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Brugia malayi serine/threonine-protein kinase PAK 7 0.0021 0.0074 0.0175
Trypanosoma brucei rac serine-threonine kinase, putative 0.0191 0.1514 0.4893
Echinococcus granulosus fmrfamide receptor 0.0054 0.0349 0.064
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.1473 0.4762
Brugia malayi nuclear receptor RXR 0.0025 0.0102 0.0242
Echinococcus granulosus protein kinase c iota type 0.0096 0.0708 0.1307
Echinococcus multilocularis cyclins 0.0055 0.0358 0.0495
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Schistosoma mansoni neuropeptide receptor 0.0054 0.0349 0.064
Loa Loa (eye worm) AGC/PKN protein kinase 0.0086 0.0621 0.1151
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.023 0.1266
Brugia malayi hypothetical protein 0.0109 0.0821 0.1944
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0056 0.0098
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0026 0.0042
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.001
Trypanosoma cruzi rac serine-threonine kinase, putative 0.011 0.0826 0.2664
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0219 0.1754 0.3248
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0226 0.0722
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2171 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Echinococcus granulosus growth factor receptor bound protein 2 0.0021 0.0071 0.0125
Echinococcus multilocularis cyclins 0.0055 0.0358 0.0495
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0007
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0015 0.002 0.003
Trichomonas vaginalis AGC family protein kinase 0.0116 0.088 0.4043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.001
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0026 0.026
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0065 0.0699
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0821 0.1143
Brugia malayi intermediate filament protein 0.0113 0.0854 0.2022
Toxoplasma gondii ABC1 family protein 0.0186 0.1473 0.9848
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0237
Brugia malayi hypothetical protein 0.0025 0.0102 0.0242
Trichomonas vaginalis cyclin B, putative 0.0106 0.0794 0.3648
Loa Loa (eye worm) hypothetical protein 0.0113 0.0854 0.1585
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0883 0.0859
Brugia malayi Trypsin-like protease protein 5 0.0013 0.0005 0.0013
Leishmania major DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0226 0.0201
Schistosoma mansoni adapter molecule crk 0.0021 0.0071 0.0125
Schistosoma mansoni lipoxygenase 0.0057 0.0378 0.0695
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0017 0.0032
Echinococcus multilocularis cyclins 0.0055 0.0358 0.0495
Onchocerca volvulus 0.0013 0.0005 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0339 0.0623
Onchocerca volvulus 0.0054 0.0349 0.0817
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0102 0.0242
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0054 0.0349 0.0482
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0339 0.0469
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0025 0.004
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Leishmania major pyruvate kinase 0.0034 0.018 0.0571
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.023 0.1516
Echinococcus multilocularis cyclins 0.0055 0.0358 0.0495
Onchocerca volvulus 0.0113 0.0854 0.2015
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1387 0.6382
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0102 0.019
Schistosoma mansoni tyrosine kinase 0.0025 0.0106 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Trypanosoma cruzi p21-activated kinase 3, putative 0.0028 0.0128 0.0402
Loa Loa (eye worm) pyruvate kinase 0.0034 0.018 0.0334
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0226 0.1246
Schistosoma mansoni histone deacetylase 4 5 0.0051 0.0325 0.0597
Brugia malayi Protein kinase domain containing protein 0.0086 0.0621 0.1469
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0043 0.0259 0.0474
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.1629 0.3854
Echinococcus multilocularis pyruvate kinase 0.0017 0.0039 0.005
Trichomonas vaginalis AGC family protein kinase 0.0191 0.1514 0.6968
Echinococcus multilocularis Mastin 0.0013 0.0005 0.0002
Brugia malayi follicle stimulating hormone receptor 0.0054 0.0349 0.0825
Trichomonas vaginalis cyclin B3, putative 0.0055 0.0358 0.1636
Mycobacterium ulcerans esterase/lipase LipP 0.0186 0.1473 0.8276
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0053 0.0339 0.0469
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0056 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0349 0.0482
Schistosoma mansoni hypothetical protein 0.002 0.0065 0.0114
Echinococcus multilocularis tumor protein p63 0.0344 0.282 0.3936
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.0349 0.064
Echinococcus granulosus aurora kinase A 0.0116 0.088 0.1626
Echinococcus multilocularis serine:threonine protein kinase 38 0.0086 0.0621 0.0862
Echinococcus multilocularis beta LACTamase domain containing family member 0.0186 0.1473 0.2053
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0026 0.0155
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0529 0.0734
Echinococcus granulosus g protein coupled receptor 0.0054 0.0349 0.064
Echinococcus granulosus tumor protein p63 0.0344 0.282 0.5228
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.018 0.1181
Brugia malayi Histone deacetylase family protein 0.0051 0.0325 0.077
Entamoeba histolytica hypothetical protein 0.0109 0.0821 0.4607
Schistosoma mansoni hypothetical protein 0.0165 0.1293 0.2393
Brugia malayi SRC-1 0.0055 0.0359 0.0849
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0441 0.0811
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0186 0.1473 0.2733
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Onchocerca volvulus 0.0054 0.0349 0.0817
Echinococcus multilocularis G protein coupled receptor 139 0.0054 0.0349 0.0482
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0102 0.0183
Echinococcus granulosus g protein coupled receptor 0.0054 0.0349 0.064
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0069 0.0482 0.0894
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.018 0.0426
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Echinococcus granulosus importin subunit beta 1 0.0061 0.0406 0.0747
Schistosoma mansoni amine GPCR 0.0054 0.0349 0.064
Loa Loa (eye worm) melatonin receptor type 1A 0.0054 0.0349 0.0647
Onchocerca volvulus 0.0186 0.1473 0.3481
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0036 0.0199 0.0471
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.027 0.0863
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0056 0.0074
Onchocerca volvulus 0.0015 0.0017 0.0032
Schistosoma mansoni hypothetical protein 0.0013 0.0005 0.0003
Schistosoma mansoni cyclins 0.0055 0.0358 0.0658
Onchocerca volvulus 0.0025 0.0102 0.0234
Loa Loa (eye worm) AGC/AKT protein kinase 0.0191 0.1514 0.2808
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0307 0.0564
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Plasmodium vivax glutathione reductase, putative 0.0046 0.0282 0.1895
Brugia malayi nuclear hormone receptor 0.0053 0.0339 0.0803
Brugia malayi Protein kinase domain containing protein 0.0015 0.002 0.0047
Schistosoma mansoni rab6-interacting 0.002 0.0065 0.0114
Schistosoma mansoni neuropeptide receptor 0.0054 0.0349 0.064
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.027 0.1501
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Trypanosoma cruzi aurora B kinase, putative 0.0116 0.088 0.2839
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0282 0.0256
Echinococcus granulosus glycoprotein Antigen 5 0.0013 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0168 0.0312
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0015 0.0017 0.0075
Echinococcus granulosus histone deacetylase 6 0.0051 0.0325 0.0597
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0102 0.0242
Onchocerca volvulus 0.0013 0.0005 0.0004
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.023 0.0316
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0102 0.0242
Trichomonas vaginalis cyclins, putative 0.0064 0.044 0.2011
Echinococcus granulosus Protein kinase C brain isozyme 0.0096 0.0708 0.1307
Entamoeba histolytica hypothetical protein 0.0109 0.0821 0.4607
Entamoeba histolytica cyclin family protein 0.0055 0.0358 0.1997
Echinococcus granulosus neuropeptide s receptor 0.0054 0.0349 0.064
Echinococcus multilocularis cyclin dependent kinase 0.0049 0.0307 0.0424
Schistosoma mansoni pyruvate kinase 0.0017 0.0039 0.0066
Giardia lamblia Kinase, STE STE20 0.0044 0.0269 0.1493
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0065 0.0086
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0226 0.0413
Loa Loa (eye worm) hypothetical protein 0.0215 0.1725 0.3199
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2171 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0023 0.0063
Schistosoma mansoni biogenic amine receptor 0.0054 0.0349 0.064
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0004 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0039 0.0242
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0186 0.1473 0.2728
Schistosoma mansoni steroid hormone receptor ad4bp 0.0053 0.0339 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0053 0.0339 0.0803
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0349 0.064
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2171 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0053 0.0339 0.0469
Schistosoma mansoni 6-phosphofructokinase 0.0376 0.309 0.5728
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.021 0.0384
Loa Loa (eye worm) hypothetical protein 0.0095 0.0699 0.1297
Schistosoma mansoni serine/threonine-protein kinase 0.011 0.0826 0.1526
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0015 0.0022
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0086 0.0621 0.1151
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.018 0.0571
Giardia lamblia Hypothetical protein 0.0222 0.1779 1
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0017 0.0032
Echinococcus granulosus Glutaredoxin protein 5 0.0103 0.0766 0.1415
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0339 0.0803
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1467 0.6754
Plasmodium falciparum glutathione reductase 0.0046 0.0282 0.3178
Trypanosoma cruzi cyclin 6, putative 0.0106 0.0794 0.2561
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.001
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0096 0.0708 0.0984
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0358 0.1636
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.1345 0.249
Onchocerca volvulus 0.0054 0.0349 0.0817
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0102 0.0138
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0102 0.0183
Brugia malayi hypothetical protein 0.0052 0.0331 0.0784
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0054 0.0349 0.0647
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0783 0.5242
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0883 0.0859
Brugia malayi putative neuropeptide receptor NPR1 0.0054 0.0349 0.0825
Leishmania major histone deacetylase, putative 0.0051 0.0325 0.1042
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.018 0.0417
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.0023 0.009
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0103 0.0766 0.1415
Schistosoma mansoni hypothetical protein 0.014 0.1079 0.1995
Schistosoma mansoni protein kinase 0.0116 0.088 0.1626
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0227 0.103
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0056 0.0171
Trypanosoma brucei trypanothione reductase 0.0046 0.0282 0.0902
Schistosoma mansoni tyrosine kinase 0.0262 0.2122 0.3931
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.002 0.0065 0.0199
Trichomonas vaginalis cyclin D, putative 0.0055 0.0358 0.1636
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0053 0.0339 0.0629
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0883 0.5929
Echinococcus granulosus lamin dm0 0.0113 0.0854 0.1579
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0026 0.0153
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0026 0.0074
Echinococcus multilocularis PAK box P21 Rho binding 0.0017 0.0032 0.0039
Schistosoma mansoni rab6-interacting 0.002 0.0065 0.0114
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0441 0.0811
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.0349 0.0647
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0349 0.064
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0108 0.0808 0.1124
Brugia malayi hypothetical protein 0.0054 0.0349 0.0825
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0621 0.2847
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.021 0.039
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.027 0.0501
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0102 0.0183
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0054 0.0349 0.064
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0194 0.1181
Loa Loa (eye worm) DR-78 0.0025 0.0102 0.019
Brugia malayi G-protein coupled receptor 0.0054 0.0349 0.0825
Echinococcus multilocularis aryl hydrocarbon receptor 0.0052 0.0333 0.0461
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0092 0.0171
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.027 0.1785
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0054 0.0349 0.0482
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0053 0.0339 0.0469
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.021 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0023 0.009
Trypanosoma brucei histone deacetylase, putative 0.0051 0.0325 0.1042
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0013 0.0005 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.1043 0.1929
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0359 0.0496
Loa Loa (eye worm) AUR protein kinase 0.0116 0.088 0.1632
Brugia malayi hypothetical protein 0.0054 0.0349 0.0825
Loa Loa (eye worm) hypothetical protein 0.0034 0.018 0.0334
Loa Loa (eye worm) hypothetical protein 0.0053 0.0339 0.0629
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0226 0.0722
Brugia malayi protein-tyrosine kinase 0.0044 0.027 0.0638
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0309 0.0988
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0325 0.1042
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.004 0.0231 0.0546
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0017 0.0032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0026 0.0074
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0023 0.0086 0.0153
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0349 0.0482
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0307 0.057
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0226 0.1255
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1387 0.6382
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Loa Loa (eye worm) AGC/NDR protein kinase 0.0086 0.0621 0.1151
Trichomonas vaginalis cyclin A, putative 0.0106 0.0794 0.3648
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.027 0.0372
Echinococcus granulosus 7tm_1 domain containing protein 0.0054 0.0349 0.064
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0102 0.0183
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.0349 0.0647
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0226 0.042
Loa Loa (eye worm) hypothetical protein 0.0044 0.0266 0.0493
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0783 0.0759
Schistosoma mansoni hypothetical protein 0.0054 0.0349 0.064
Schistosoma mansoni protein kinase 0.0017 0.0032 0.0052
Schistosoma mansoni ap endonuclease 0.0019 0.0056 0.0098
Schistosoma mansoni lamin 0.0113 0.0854 0.1579
Brugia malayi Cyclin, N-terminal domain containing protein 0.0013 0.0004 0.0009
Schistosoma mansoni hypothetical protein 0.0109 0.0821 0.1518
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0122 0.0384
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0309 0.1407
Echinococcus granulosus cyclins 0.0055 0.0358 0.0658
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0116 0.088 0.1224
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0021 0.0071 0.0125
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0222 0.1779 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0883 0.0859
Brugia malayi hypothetical protein 0.0054 0.0349 0.0825
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0052
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0854 0.716 1
Echinococcus granulosus hypothetical protein 0.0054 0.0349 0.064
Schistosoma mansoni histone deacetylase 4 5 0.0051 0.0325 0.0597
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Schistosoma mansoni pyruvate kinase 0.0034 0.018 0.0327
Echinococcus granulosus cyclins 0.0055 0.0358 0.0658
Brugia malayi hypothetical protein 0.0054 0.0349 0.0825
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0102 0.019
Echinococcus multilocularis musashi 0.0113 0.0854 0.1189
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0102 0.0234
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0088 0.0636 0.1179
Brugia malayi Tyrosine-protein kinase abl-1 0.013 0.0995 0.2354
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0026 0.0213
Loa Loa (eye worm) histone deacetylase 0.0051 0.0325 0.0603
Onchocerca volvulus 0.0015 0.0017 0.0032
Brugia malayi Uncoordinated protein 44 0.0015 0.0015 0.0037
Schistosoma mansoni ran 0.0045 0.027 0.0495
Schistosoma mansoni amine GPCR 0.0054 0.0349 0.064
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0186 0.1473 0.1451
Brugia malayi nuclear receptor NHR-88 0.0053 0.0339 0.0803
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0349 0.0482
Trichomonas vaginalis AGC family protein kinase 0.0106 0.0797 0.366
Schistosoma mansoni inositol monophosphatase 0.004 0.023 0.042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0349 0.064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.0074
Loa Loa (eye worm) hypothetical protein 0.0053 0.0339 0.0629
Echinococcus multilocularis PAK box P21 Rho binding 0.0021 0.0074 0.0098
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0021 0.0069 0.0122
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0056 0.0359
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0307 0.0984
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0349 0.0482
Brugia malayi cyclin fold protein 1 variant b 0.0013 0.0004 0.0009
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0113 0.0854 0.1585
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Echinococcus granulosus dro:myosuppressin receptor 0.0054 0.0349 0.064
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0349 0.064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0053 0.0339 0.0629
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0186 0.1473 0.8276
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0307 0.057
Brugia malayi cytoplasmic intermediate filament protein 0.0061 0.0407 0.0963
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.1043 0.1452
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0054 0.0349 0.0647
Trichomonas vaginalis cyclin B, putative 0.0106 0.0794 0.3648
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.0369 0.3036 0.9825
Echinococcus multilocularis pyruvate kinase 0.0017 0.0039 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.0074
Toxoplasma gondii exonuclease III APE 0.0019 0.0056 0.0353
Onchocerca volvulus 0.0052 0.0331 0.0776
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0102 0.0138
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0023 0.009
Entamoeba histolytica hypothetical protein 0.0017 0.0032 0.0159
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0339 0.0623
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0016 0.0024 0.0115
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0054 0.0349 0.0647
Loa Loa (eye worm) hypothetical protein 0.0036 0.0199 0.0369
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0186 0.1473 0.3487
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Brugia malayi Protein kinase domain containing protein 0.0015 0.0017 0.004
Brugia malayi G-protein coupled receptor 0.0054 0.0349 0.0825
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0339 0.0803
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.0074
Leishmania major importin beta-1 subunit, putative 0.0049 0.0309 0.0988
Plasmodium falciparum importin beta, putative 0.0061 0.0406 0.4594
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Schistosoma mansoni histamine h1 receptor 0.0054 0.0349 0.064
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0116 0.088 0.4935
Schistosoma mansoni growth hormone secretagogue receptor 0.0054 0.0349 0.064
Brugia malayi beta-lactamase family protein 0.0186 0.1473 0.3487
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0021 0.0069 0.0092
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0049 0.0307 0.0564
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0052 0.0333 0.0618
Onchocerca volvulus 0.0095 0.0699 0.1647
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0054 0.0349 0.0482
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0023 0.0063
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0349 0.064
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0005 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0102 0.0183
Loa Loa (eye worm) cyclin domain-containing protein 0.0013 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0052
Echinococcus multilocularis growth factor receptor bound protein 2 0.0021 0.0071 0.0094
Echinococcus multilocularis serotonin receptor 0.0054 0.0349 0.0482
Loa Loa (eye worm) hypothetical protein 0.0036 0.0199 0.0369
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0102 0.0138
Onchocerca volvulus Protein cycle homolog 0.0036 0.0201 0.0468
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1378 0.2551
Plasmodium falciparum glutathione reductase 0.0016 0.0026 0.026
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0092 0.0675 0.2175
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0369 0.3036 0.9825
Trichomonas vaginalis AGC family protein kinase 0.0191 0.1514 0.6968
Brugia malayi hypothetical protein 0.002 0.0065 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0053 0.0339 0.0629
Onchocerca volvulus 0.0093 0.0681 0.1605
Brugia malayi Cyclin, N-terminal domain containing protein 0.0106 0.0794 0.188
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0017 0.0032 0.0052
Brugia malayi Protein kinase domain containing protein 0.0049 0.0307 0.0728
Onchocerca volvulus 0.0015 0.0017 0.0032
Echinococcus multilocularis Ankyrin 0.0015 0.0017 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0349 0.064
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0128 0.023
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0349 0.064
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0102 0.0234
Loa Loa (eye worm) hypothetical protein 0.014 0.1079 0.2001
Trichomonas vaginalis AGC family protein kinase 0.0106 0.0797 0.366
Echinococcus granulosus g-protein coupled receptor 0.0054 0.0349 0.064
Schistosoma mansoni myosin xvIII 0.0054 0.0349 0.064
Echinococcus multilocularis serotonin receptor 0.0054 0.0349 0.0482
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0061 0.0407 0.0755
Echinococcus granulosus NDR protein kinase 0.0086 0.0621 0.1145
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0441 0.1043
Schistosoma mansoni amine GPCR 0.0054 0.0349 0.064
Trichomonas vaginalis cyclin D, putative 0.0055 0.0358 0.1636
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0016 0.003 0.0086
Brugia malayi RNA, U transporter 1 0.0172 0.1356 0.3209
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0055 0.0359 0.0496
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus multilocularis muscleblind protein 0.0153 0.1194 0.1664
Trichomonas vaginalis penicillin-binding protein, putative 0.0186 0.1473 0.6781
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.018 0.0426
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0054 0.0349 0.0825
Toxoplasma gondii aurora kinase 0.0116 0.088 0.5871
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0226 0.0201
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0054 0.0349 0.0825
Brugia malayi neuropeptide F receptor 0.0054 0.0349 0.0825
Brugia malayi conserved hypotetical protein 0.0025 0.0102 0.0242
Brugia malayi Death domain containing protein 0.0015 0.0015 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0349 0.064
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.027 0.0495
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0017 0.0032 0.0059
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0086 0.0621 0.1151
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0349 0.0482
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0056 0.0171
Brugia malayi Serotonin receptor 0.0054 0.0349 0.0825
Brugia malayi hypothetical protein 0.0013 0.0005 0.0013
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0017 0.0032 0.0052
Brugia malayi hypothetical protein 0.0054 0.0349 0.0825
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0021 0.0069 0.0129
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0029
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0369 0.3036 0.9825
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0376 0.309 1
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Brugia malayi hypothetical protein 0.002 0.0065 0.0154
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0043 0.0259 0.0357
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0015 0.0028
Echinococcus granulosus G2:mitotic specific cyclin B3 0.017 0.1335 0.2471
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2171 1
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0349 0.0482
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0349 0.064
Trichomonas vaginalis STE family protein kinase 0.0044 0.0269 0.1223
Loa Loa (eye worm) hypothetical protein 0.0051 0.0325 0.0603
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.016 0.1256 0.4058
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0102 0.0242
Loa Loa (eye worm) hypothetical protein 0.0036 0.0199 0.0369
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0349 0.0482
Entamoeba histolytica hypothetical protein 0.0017 0.0032 0.0159
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0069 0.0482 0.1549
Trichomonas vaginalis STE family protein kinase 0.0044 0.0269 0.1223
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.023 1
Schistosoma mansoni serine/threonine kinase 0.0086 0.0621 0.1145
Brugia malayi hypothetical protein 0.0054 0.0349 0.0825
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0226 0.0722
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1043 0.1929
Onchocerca volvulus Protein ultraspiracle homolog 0.0053 0.0339 0.0795
Echinococcus multilocularis G-protein coupled receptor, putative 0.0054 0.0349 0.0482
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0406 0.2697
Schistosoma mansoni protein kinase 0.0044 0.0269 0.0492
Schistosoma mansoni retinoic acid receptor RXR 0.0053 0.0339 0.0623
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0325 0.1042
Schistosoma mansoni RAR-like nuclear receptor 0.0053 0.0339 0.0623
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0039 0.0238
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0128 0.0237
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0053 0.0339 0.0623
Schistosoma mansoni nuclear receptor 0.0025 0.0102 0.0183
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Brugia malayi hypothetical protein 0.0509 0.4225 1
Brugia malayi glutathione reductase 0.0046 0.0282 0.0668
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.016 0.1256 0.4058
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0053 0.0339 0.0623
Mycobacterium ulcerans lipase LipD 0.0186 0.1473 0.8276
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0349 0.064
Echinococcus granulosus histone deacetylase 0.0051 0.0325 0.0597
Echinococcus granulosus RUN 0.002 0.0065 0.0114
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.023 0.1274
Onchocerca volvulus 0.0054 0.0349 0.0817
Echinococcus multilocularis thyroid hormone receptor alpha 0.0053 0.0339 0.0469
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Schistosoma mansoni neuropeptide receptor 0.0054 0.0349 0.064
Loa Loa (eye worm) hypothetical protein 0.0065 0.0441 0.0817
Echinococcus granulosus dna polymerase eta 0.0039 0.0226 0.0413
Echinococcus multilocularis GPCR, family 2 0.0065 0.0441 0.0611
Brugia malayi Trypsin family protein 0.0013 0.0005 0.0013
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0026 0.0105
Entamoeba histolytica hypothetical protein 0.0109 0.0821 0.4607
Echinococcus multilocularis raf serine:threonine protein kinase 0.0014 0.0013 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.2171 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0055 0.0359 0.0659
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.088 0.1626
Loa Loa (eye worm) hypothetical protein 0.0204 0.1629 0.3021
Loa Loa (eye worm) hypothetical protein 0.0376 0.309 0.5731
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0054 0.0349 0.0482
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0294 0.0697
Schistosoma mansoni alpha-1 adrenergic receptor 0.0054 0.0349 0.064
Schistosoma mansoni tyrosine kinase 0.0025 0.0106 0.019
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0349 0.064
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.023 0.0733
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0359 0.0659
Schistosoma mansoni biogenic amine receptor 0.0054 0.0349 0.064
Loa Loa (eye worm) glutathione reductase 0.0046 0.0282 0.0523
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0128 0.0302
Echinococcus multilocularis cyclin B 0.0106 0.0794 0.1105
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0349 0.064
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1387 0.6382
Echinococcus granulosus tyrosine protein kinase ABL1 0.0225 0.1804 0.3341
Echinococcus granulosus tyrosine protein kinase Src64B 0.0055 0.0359 0.0659
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0054 0.0349 0.064
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.0074
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0056 0.0171
Loa Loa (eye worm) hypothetical protein 0.005 0.032 0.0593
Echinococcus multilocularis cyclins 0.0055 0.0358 0.0495
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0026 0.0074
Brugia malayi hypothetical protein 0.0232 0.1869 0.4424
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1473 0.6781
Loa Loa (eye worm) hypothetical protein 0.0053 0.0338 0.0628
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0349 0.0482
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0102 0.0183
Trichomonas vaginalis ran, putative 0.0045 0.027 0.1229
Echinococcus multilocularis NCK adaptor protein 0.0021 0.0071 0.0094
Echinococcus multilocularis tyrosine kinase 0.0015 0.0017 0.0019
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0349 0.0482
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Echinococcus granulosus cyclin B 0.0106 0.0794 0.1467
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0339 0.0623
Leishmania major DNA polymerase eta, putative 0.0039 0.0226 0.0722
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0015 0.002 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0102 0.0183
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.002 0.0065 0.0199
Loa Loa (eye worm) hypothetical protein 0.0061 0.0406 0.0753
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1387 0.6382
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.0359 0.0496
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0171 0.1345 0.249
Brugia malayi hypothetical protein 0.0054 0.0349 0.0825
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0821 0.1518
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0049 0.0307 0.0984
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Mycobacterium leprae Probable lipase LipE 0.0186 0.1473 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0783 0.0759
Echinococcus granulosus cyclin B3 1 0.0055 0.0358 0.0658
Mycobacterium tuberculosis Probable lipase LipD 0.0186 0.1473 0.1451
Echinococcus granulosus Mastin 0.0013 0.0005 0.0003
Trypanosoma cruzi cyclin, putative 0.0106 0.0794 0.2561
Schistosoma mansoni amine GPCR 0.0054 0.0349 0.064
Echinococcus multilocularis neuropeptide receptor A26 0.0054 0.0349 0.0482
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0359 0.0659
Brugia malayi Steroid receptor seven-up type 2 0.0053 0.0339 0.0803
Echinococcus granulosus histone deacetylase 7 0.0051 0.0325 0.0597
Schistosoma mansoni hypothetical protein 0.0015 0.0015 0.0022
Brugia malayi AKH receptor 0.0054 0.0349 0.0825
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0054 0.0349 0.064
Plasmodium vivax pyruvate kinase, putative 0.0034 0.018 0.1199
Brugia malayi beta-lactamase family protein 0.0186 0.1473 0.3487
Schistosoma mansoni hypothetical protein 0.0047 0.0294 0.054
Plasmodium vivax hypothetical protein, conserved 0.0186 0.1473 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0307 0.1711
Schistosoma mansoni tyrosine kinase 0.0055 0.0359 0.0659
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.1473 0.4762
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0026 0.0042
Onchocerca volvulus 0.0054 0.0349 0.0817
Entamoeba histolytica protein kinase, putative 0.0116 0.088 0.4935
Echinococcus granulosus neuropeptide receptor 0.0054 0.0349 0.064
Schistosoma mansoni pyruvate kinase 0.0034 0.018 0.0327
Echinococcus granulosus peptide allatostatin:somatostatin 0.0054 0.0349 0.064
Echinococcus granulosus pyruvate kinase 0.0017 0.0039 0.0066
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0026 0.026
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0023 0.009
Brugia malayi Protein kinase c protein 2 0.0015 0.002 0.0047
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0349 0.064
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0406 0.1304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0349 0.0482
Loa Loa (eye worm) hypothetical protein 0.0053 0.0338 0.0628
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Loa Loa (eye worm) hypothetical protein 0.0153 0.1194 0.2215
Echinococcus granulosus snurportin 1 0.0646 0.5391 1
Echinococcus multilocularis lamin dm0 0.0113 0.0854 0.1189
Brugia malayi Neuronal symmetry protein 1 0.0219 0.1754 0.415
Schistosoma mansoni hypothetical protein 0.0065 0.0441 0.0811
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0646 0.5391 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.0074
Echinococcus multilocularis orexin receptor type 2 0.0054 0.0349 0.0482
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Echinococcus granulosus intermediate filament protein 0.0113 0.0854 0.1579
Brugia malayi Protein kinase domain containing protein 0.0015 0.0017 0.004
Brugia malayi ORL1-like opioid receptor 0.0054 0.0349 0.0825
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0005 0.0003
Onchocerca volvulus 0.002 0.0065 0.0145
Brugia malayi Cyclin, N-terminal domain containing protein 0.017 0.1335 0.3159
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0106 0.0794 0.2561
Echinococcus multilocularis c src tyrosine kinase 0.0025 0.0106 0.0143
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0102 0.0183
Brugia malayi sulfakinin receptor protein 0.0054 0.0349 0.0825
Giardia lamblia Kinase, AGC PKA 0.0108 0.0808 0.4531
Echinococcus multilocularis tyrosine protein kinase shark 0.0015 0.0018 0.002
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0069 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0053 0.0339 0.0803
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0194 0.0168
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0053 0.0339 0.0623
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0349 0.0482
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0026 0.0109 0.0485
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.088 0.4935
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0028 0.0128 0.0572
Loa Loa (eye worm) TYRA-2 protein 0.0054 0.0349 0.0647
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0189 0.0857
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0102 0.0138
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0175 0.1378 0.2556
Loa Loa (eye worm) hypothetical protein 0.0053 0.0339 0.0629
Echinococcus granulosus allatostatin A receptor 0.0054 0.0349 0.064
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.027 0.0372
Mycobacterium tuberculosis Conserved protein 0.0186 0.1473 0.1451
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0053 0.0339 0.0469
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.017 0.1335 0.186
Onchocerca volvulus 0.0047 0.0294 0.0689
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.016 0.1256 0.4058
Brugia malayi hypothetical protein 0.0028 0.0128 0.0302
Echinococcus granulosus pyruvate kinase 0.0017 0.0039 0.0066
Schistosoma mansoni growth factor receptor-bound protein 0.0021 0.0071 0.0125
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0054 0.0349 0.064
Echinococcus granulosus tyrosine protein kinase Lyn 0.006 0.0401 0.0737
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0044 0.0269 0.0492
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0226 0.0536
Echinococcus multilocularis nervana 2 0.0103 0.0766 0.1065
Echinococcus multilocularis rac serine:threonine kinase 0.011 0.0826 0.1149
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0307 0.1711
Onchocerca volvulus 0.0013 0.0005 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Echinococcus granulosus histone deacetylase 6 0.0051 0.0325 0.0597
Entamoeba histolytica protein kinase, putative 0.0016 0.0024 0.0115
Echinococcus granulosus muscleblind protein 0.0153 0.1194 0.221
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0102 0.0138
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0071 0.0169
Entamoeba histolytica protein kinase, putative 0.0043 0.0259 0.1439
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0186 0.1473 0.2728
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.001
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0108 0.0808 0.918
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.023 0.1044
Entamoeba histolytica protein kinase, putative 0.0024 0.0092 0.0495
Mycobacterium tuberculosis Probable lipase LipE 0.0186 0.1473 0.1451
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0098 0.0723 0.1711
Loa Loa (eye worm) hypothetical protein 0.0053 0.0339 0.0629
Schistosoma mansoni cellular tumor antigen P53 0.005 0.032 0.0586
Trypanosoma brucei unspecified product 0.0027 0.0122 0.0384
Echinococcus multilocularis g-protein coupled receptor 0.0054 0.0349 0.0482
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0406 0.1304
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0044 0.0269 0.037
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Brugia malayi Importin beta-1 subunit 0.0061 0.0406 0.0961
Echinococcus multilocularis cyclin B3 1 0.0055 0.0358 0.0495
Schistosoma mansoni netrin receptor unc5 0.0015 0.0015 0.0022
Schistosoma mansoni vav2 0.0023 0.0087 0.0155
Loa Loa (eye worm) TK/FAK protein kinase 0.0265 0.2148 0.3984
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Loa Loa (eye worm) trypsin family protein 0.0013 0.0005 0.001
Brugia malayi Muscleblind-like protein 0.0153 0.1194 0.2827
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0116 0.088 0.5962
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Onchocerca volvulus 0.0054 0.0349 0.0817
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0056 0.0243
Echinococcus multilocularis lamin 0.0113 0.0854 0.1189
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.018 0.0813
Loa Loa (eye worm) intermediate filament protein 0.0113 0.0854 0.1585
Echinococcus granulosus dna polymerase kappa 0.0039 0.0226 0.0413
Leishmania major trypanothione reductase 0.0046 0.0282 0.0902
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0369 0.3036 0.9825
Echinococcus multilocularis dro:myosuppressin receptor 0.0054 0.0349 0.0482
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0086 0.0621 0.0862
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0044 0.0269 0.0492
Echinococcus granulosus tyrosine protein kinase HCK 0.0034 0.0178 0.0324
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.0359 0.0659
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0036 0.0201 0.0373
Echinococcus multilocularis glycoprotein Antigen 5 0.0013 0.0005 0.0002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0226 0.0413
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0128 0.0173
Onchocerca volvulus 0.0113 0.0854 0.2015
Echinococcus multilocularis serine:threonine protein kinase N2 0.0086 0.0621 0.0862
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0017 0.0024
Mycobacterium tuberculosis Probable esterase LipL 0.0186 0.1473 0.1451
Schistosoma mansoni growth factor receptor-bound protein 0.0021 0.0071 0.0125
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Brugia malayi Trypsin family protein 0.0013 0.0005 0.0013
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.0349 0.0647
Trichomonas vaginalis cyclins, putative 0.0106 0.0794 0.3648
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0325 0.0449
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.0349 0.064
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0307 0.0564
Schistosoma mansoni hypothetical protein 0.0594 0.4946 0.9172
Brugia malayi Intermediate filament tail domain containing protein 0.0113 0.0854 0.2022
Loa Loa (eye worm) hypothetical protein 0.0039 0.0226 0.042
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0441 0.0817
Echinococcus granulosus aryl hydrocarbon receptor 0.0052 0.0333 0.0612
Echinococcus granulosus cyclins 0.0055 0.0358 0.0658
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0171 0.1345 0.2495
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0226 0.1246
Brugia malayi MH2 domain containing protein 0.0116 0.0879 0.208
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Loa Loa (eye worm) TK protein kinase 0.0044 0.027 0.05
Loa Loa (eye worm) hypothetical protein 0.0186 0.1473 0.2733
Onchocerca volvulus 0.0106 0.0794 0.1872
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0325 0.0449
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0259 0.0474
Echinococcus granulosus tyrosine protein kinase Srms 0.0015 0.0017 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0879 0.163
Schistosoma mansoni importin beta-1 0.0061 0.0406 0.0747
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0282 0.0523
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0053 0.0339 0.0629
Onchocerca volvulus 0.0054 0.0349 0.0817
Echinococcus granulosus NCK adaptor protein 0.0021 0.0071 0.0125
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0025 0.0106 0.019
Echinococcus granulosus lamin 0.0113 0.0854 0.1579
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0339 0.0623
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0226 0.0722
Loa Loa (eye worm) hypothetical protein 0.0055 0.0356 0.066
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0121
Loa Loa (eye worm) pyruvate kinase 0.0034 0.018 0.0334
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0237
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0708 0.1307
Echinococcus granulosus serotonin receptor 0.0054 0.0349 0.064
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1387 0.6382
Schistosoma mansoni hypothetical protein 0.0013 0.0005 0.0003
Schistosoma mansoni hypothetical protein 0.0054 0.0349 0.064
Brugia malayi hypothetical protein 0.0025 0.0102 0.0242
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0307 0.1402
Echinococcus granulosus cyclin b3 0.0055 0.0358 0.0658
Mycobacterium leprae conserved hypothetical protein 0.0186 0.1473 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0044 0.0269 0.037
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0015 0.0017 0.0019
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0054 0.0349 0.0482
Loa Loa (eye worm) hypothetical protein 0.0053 0.0339 0.0629
Echinococcus granulosus nervana 2 0.0103 0.0766 0.1415
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0017 0.0032
Loa Loa (eye worm) beta-lactamase 0.0186 0.1473 0.2733
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0065 0.0114
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0015 0.0017 0.0025
Brugia malayi SH2 domain containing protein 0.0015 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0186 0.1473 0.2733
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0021 0.0069 0.0122
Schistosoma mansoni cyclin B3 0.017 0.1335 0.2471
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0023 0.009
Schistosoma mansoni hypothetical protein 0.0065 0.0441 0.0811
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0339 0.0803
Brugia malayi Cyclin, N-terminal domain containing protein 0.0106 0.0794 0.188
Trichomonas vaginalis AGC family protein kinase 0.0191 0.1514 0.6968
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.023 0.1044
Schistosoma mansoni DNA polymerase eta 0.0039 0.0226 0.0413
Toxoplasma gondii hypothetical protein 0.0042 0.0246 0.162
Brugia malayi beta-lactamase 0.0186 0.1473 0.3487
Trypanosoma brucei hypothetical protein, conserved 0.0186 0.1473 0.4762
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0349 0.0482
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0013 0.0004 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0349 0.064
Brugia malayi hypothetical protein 0.0028 0.0128 0.0302
Brugia malayi Histone deacetylase family protein 0.0051 0.0325 0.077
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0026 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0023 0.009
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0055 0.0356 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0053 0.0339 0.0803
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0108 0.0808 0.2606
Schistosoma mansoni survival motor neuron protein 0.0047 0.0294 0.054
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0017 0.0032
Loa Loa (eye worm) hypothetical protein 0.0186 0.1473 0.2733
Brugia malayi Hr1 repeat family protein 0.0086 0.0621 0.1469
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0349 0.064
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0783 0.0759
Loa Loa (eye worm) hypothetical protein 0.0054 0.0349 0.0647
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0005 0.0003
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0055 0.0359 0.0659
Brugia malayi hypothetical protein 0.0054 0.0349 0.0825
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0103 0.0766 0.1065
Brugia malayi Trypsin family protein 0.0013 0.0005 0.0013
Toxoplasma gondii AGC kinase 0.0189 0.1496 1
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0708 0.1307
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0044 0.0269 0.0492
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.001
Brugia malayi neuropeptide F receptor 0.0054 0.0349 0.0825
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.0074
Loa Loa (eye worm) hypothetical protein 0.0153 0.1194 0.2215
Schistosoma mansoni inositol monophosphatase 0.004 0.023 0.042
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.0349 0.064
Loa Loa (eye worm) TK/FER protein kinase 0.0015 0.0017 0.0032
Schistosoma mansoni hypothetical protein 0.0065 0.0441 0.0811
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0349 0.0482
Schistosoma mansoni amine GPCR 0.0054 0.0349 0.064
Echinococcus multilocularis allatostatin A receptor 0.0054 0.0349 0.0482
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0226 0.0536
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.027 0.0863
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.023 0.0733
Brugia malayi ecdysone receptor 0.0025 0.0102 0.0242
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0028 0.0128 0.0237
Brugia malayi Trypsin family protein 0.0013 0.0005 0.0013
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0349 0.064
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0237
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0054 0.0349 0.064
Echinococcus granulosus sex peptide receptor 0.0054 0.0349 0.064
Brugia malayi P21-Rho-binding domain containing protein 0.0017 0.0032 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Giardia lamblia Aurora kinase 0.0116 0.088 0.4935
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0282 0.0389
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0127 0.0567
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0028 0.0127 0.0567
Brugia malayi Thioredoxin reductase 0.0046 0.0282 0.0668
Schistosoma mansoni ap endonuclease 0.0019 0.0056 0.0098
Trypanosoma cruzi Protein kinase B 0.011 0.0826 0.2664
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0102 0.0755 0.3467
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0307 0.0984
Loa Loa (eye worm) hypothetical protein 0.0051 0.0325 0.0603
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.2171 0.5138
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0349 0.064
Loa Loa (eye worm) hypothetical protein 0.0053 0.0339 0.0629
Echinococcus multilocularis tyrosine protein kinase HCK 0.0034 0.0178 0.0244
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0189 0.0857
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0225 0.1804 0.2515
Mycobacterium ulcerans hypothetical protein 0.0222 0.1779 1
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0128 0.023
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0069 0.0482 0.1549
Echinococcus multilocularis cyclin dependent kinase 5 0.0049 0.0307 0.0424
Brugia malayi Protein kinase domain containing protein 0.0106 0.0797 0.1886
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0054 0.0349 0.0482
Echinococcus granulosus serine threonine protein kinase nrc 0.0108 0.0808 0.1493
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0621 0.1145
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0055 0.0359 0.0496
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0054 0.0349 0.0647
Brugia malayi Dopamine receptor protein 1 0.0054 0.0349 0.0825
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0109 0.0485
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0106 0.0797 0.1478
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.019

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.174 uM Inhibition of HDAC in human Hela cell nuclear extract after 15 mins ChEMBL. 23644210
IC50 (functional) = 0.326 uM Cytotoxicity against human HCT116 cells ChEMBL. 23644210
Stabilty (ADMET) = 19 % Metabolic stability in mouse liver microsomes after 30 mins by LC-MS/MS analysis ChEMBL. 23644210

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23644210

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.