TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 463.934 | Formula: C21H22ClN3O5S
H donors: 2 H acceptors: 4 LogP: 3.62 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(s1)Cl)NC[C@@H]1CN(C(=O)O1)c1ccc(cc1)N1CCC(CC1)C(=O)O
InChi: 1S/C21H22ClN3O5S/c22-18-6-5-17(31-18)19(26)23-11-16-12-25(21(29)30-16)15-3-1-14(2-4-15)24-9-7-13(8-10-24)20(27)28/h1-6,13,16H,7-12H2,(H,23,26)(H,27,28)/t16-/m1/s1
InChiKey: NTHTVBYMCWQXSW-MRXNPFEDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0209	0.0541
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Leishmania major	cathepsin L-like protease	0.0316	0.1901	1
Toxoplasma gondii	cathepsin CPC1	0.0072	0.036	0.1872
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0108	0.0281
Giardia lamblia	Cathepsin B precursor	0.0072	0.036	0.2386
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0171	0.0985	0.5126
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0072	0.036	0.1802
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.036	0.1802
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0316	0.1901	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Brugia malayi	cathepsin L precursor	0.0072	0.036	0.0934
Giardia lamblia	Cathepsin B precursor	0.0072	0.036	0.2386
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0528	0.1369
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0108	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0108	0.0281
Echinococcus multilocularis	cysteine protease	0.0316	0.1901	0.1901
Leishmania major	cathepsin L-like protease	0.0316	0.1901	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0072	0.036	0.0934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.036	0.1802
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0171	0.0985	0.2512
Onchocerca volvulus		0.0094	0.0496	0.2607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.036	0.0934
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0032	0.0108	0.0281
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0316	0.1901	0.1901
Brugia malayi	Cathepsin L-like precursor	0.0099	0.0528	0.1369
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0012	0.003
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0108	0.0108
Echinococcus multilocularis	cathepsin b	0.0626	0.3856	0.3856
Brugia malayi	Papain family cysteine protease containing protein	0.0072	0.036	0.0934
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0016	0.0005	0.0013
Leishmania major	cathepsin L-like protease	0.0316	0.1901	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0032	0.0108	0.0108
Onchocerca volvulus		0.0021	0.0038	0.0198
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0108	0.0281
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0021	0.0021
Giardia lamblia	Cathepsin L precursor	0.0072	0.036	0.2386
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0316	0.1901	0.4929
Entamoeba histolytica	cysteine protease, putative	0.0072	0.036	0.1802
Trypanosoma cruzi	cysteine peptidase, putative	0.0316	0.1901	0.4901
Loa Loa (eye worm)	steroid hormone receptor	0.0032	0.0108	0.0281
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0072	0.036	0.2386
Loa Loa (eye worm)	MBCTL1	0.0107	0.0577	0.1498
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0059	0.0098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1
Onchocerca volvulus		0.0032	0.0108	0.057
Echinococcus multilocularis	polycomb protein SCMH1	0.0094	0.0496	0.0496
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0032	0.0108	0.0281
Giardia lamblia	Cathepsin B precursor	0.0072	0.036	0.2386
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0016	0.0005	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0108	0.0281
Leishmania major	cathepsin L-like protease	0.0316	0.1901	1
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0108	0.0281
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0072	0.036	0.1802
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0017	0.0012	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0032	0.0108	0.0281
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0072	0.036	0.0934
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0072	0.036	0.2386
Brugia malayi	nuclear hormone receptor	0.0032	0.0108	0.0281
Brugia malayi	Steroid receptor seven-up type 2	0.0032	0.0108	0.0281
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0072	0.036	0.1872
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0032	0.0108	0.0281
Leishmania major	cathepsin L-like protease	0.0316	0.1901	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.0108	0.0281
Brugia malayi	Cathepsin L-like precursor	0.0316	0.1901	0.4929
Giardia lamblia	Cathepsin L precursor	0.0072	0.036	0.2386
Onchocerca volvulus	Cathepsin F homolog	0.0316	0.1901	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0108	0.0281
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0072	0.036	0.0934
Giardia lamblia	Hypothetical protein	0.0072	0.036	0.2386
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Entamoeba histolytica	cysteine protease, putative	0.0072	0.036	0.1802
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0171	0.0985	0.2553
Giardia lamblia	Cathepsin L-like protease	0.0072	0.036	0.2386
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0032	0.0108	0.0108
Echinococcus multilocularis	cathepsin b	0.0626	0.3856	0.3856
Toxoplasma gondii	kringle domain-containing protein	0.0021	0.0038	0.0171
Plasmodium falciparum	serine repeat antigen 5	0.0072	0.036	0.1802
Toxoplasma gondii	exonuclease III APE	0.0019	0.0021	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0072	0.036	0.1802
Onchocerca volvulus		0.0316	0.1901	1
Onchocerca volvulus	Cathepsin L homolog	0.0316	0.1901	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0244	0.1441	0.7555
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0316	0.1901	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0072	0.036	0.1802
Schistosoma mansoni	cathepsin B (C01 family)	0.0072	0.036	0.0934
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0244	0.1441	0.3703
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0107	0.0577	0.1498
Brugia malayi	Cathepsin L-like precursor	0.0316	0.1901	0.4929
Giardia lamblia	Cysteine protease	0.0072	0.036	0.2386
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0094	0.0496	0.2607
Entamoeba histolytica	cysteine proteinase, putative	0.0316	0.1901	1
Echinococcus multilocularis	tumor protein p63	0.0331	0.199	0.199
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0108	0.0281
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0072	0.036	0.1802
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0017	0.0012	0.003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0171	0.0985	0.2512
Echinococcus granulosus	cathepsin b	0.0626	0.3856	1
Onchocerca volvulus	Bile acid receptor homolog	0.0032	0.0108	0.057
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0108	0.0281
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0072	0.036	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0577	0.1498
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0171	0.0985	0.5126
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0072	0.036	0.1802
Giardia lamblia	Cathepsin B precursor	0.0244	0.1441	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0021	0.5
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1276	0.3309
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0038	0.0043
Giardia lamblia	Cathepsin B precursor	0.0072	0.036	0.2386
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1
Plasmodium falciparum	serine repeat antigen 9	0.0072	0.036	0.1802
Trypanosoma cruzi	major cysteine proteinase, putative	0.0072	0.036	0.0883
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0072	0.036	0.0934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Echinococcus granulosus	cathepsin b	0.0626	0.3856	1
Plasmodium falciparum	serine repeat antigen 7	0.0072	0.036	0.1802
Brugia malayi	Cathepsin L-like precursor	0.0316	0.1901	0.4929
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0072	0.036	0.1802
Giardia lamblia	Encystation-specific protease	0.0072	0.036	0.2386
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Entamoeba histolytica	cysteine protease, putative	0.0072	0.036	0.1802
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0217	0.1276	0.3309
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0012	0.003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Schistosoma mansoni	sex comb on midleg homolog	0.0094	0.0496	0.1285
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0059	0.0098
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0072	0.036	0.2386
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0021	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0316	0.1901	1
Onchocerca volvulus		0.0316	0.1901	1
Brugia malayi	fibroinase precursor	0.0072	0.036	0.0934
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0072	0.036	0.1802
Echinococcus multilocularis	cathepsin L cysteine protease	0.0316	0.1901	0.1901
Trypanosoma cruzi	cysteine peptidase, putative	0.0316	0.1901	0.4901
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.036	0.1802
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0171	0.0985	0.2553
Giardia lamblia	Cysteine protease	0.0072	0.036	0.2386
Echinococcus granulosus	SAM and MBT domain containing protein	0.0094	0.0496	0.1285
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0021	0.0055
Echinococcus granulosus	cathepsin l1	0.0217	0.1276	0.3309
Echinococcus multilocularis	Tolloid protein 1	0.0016	0.0005	0.0005
Echinococcus granulosus	cathepsin L	0.0072	0.036	0.0934
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0099	0.0528	0.1369
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0171	0.0985	0.5126
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0032	0.0108	0.0281
Trypanosoma cruzi	major cysteine proteinase, putative	0.0072	0.036	0.0883
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0072	0.036	0.0934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.036	0.1802
Brugia malayi	hypothetical protein	0.0017	0.0012	0.003
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0017	0.0012	0.003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Entamoeba histolytica	hypothetical protein	0.0072	0.036	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0072	0.036	0.0934
Leishmania major	hypothetical protein, conserved	0.0021	0.0038	0.0087
Onchocerca volvulus	Protein ultraspiracle homolog	0.0032	0.0108	0.057
Echinococcus multilocularis	cathepsin L	0.0171	0.0985	0.0985
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0072	0.036	0.1802
Onchocerca volvulus		0.0316	0.1901	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0012	0.003
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0072	0.036	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1276	0.3309
Onchocerca volvulus	Cathepsin L homolog	0.0316	0.1901	1
Brugia malayi	nuclear receptor RXR	0.0017	0.0012	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0032	0.0108	0.0281
Brugia malayi	Papain family cysteine protease containing protein	0.0316	0.1901	0.4929
Loa Loa (eye worm)	hypothetical protein	0.0316	0.1901	0.4929
Plasmodium falciparum	serine repeat antigen 4	0.0072	0.036	0.1802
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Schistosoma mansoni	sex comb on midleg homolog	0.0094	0.0496	0.1285
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0179	0.1036	0.5451
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0072	0.036	0.1802
Brugia malayi	MH2 domain containing protein	0.0117	0.0641	0.1661
Brugia malayi	Fibulin-1 precursor	0.0016	0.0005	0.0013
Schistosoma mansoni	hypothetical protein	0.0574	0.3528	0.9149
Echinococcus multilocularis	cathepsin L	0.0072	0.036	0.036
Brugia malayi	Cathepsin L-like precursor	0.0316	0.1901	0.4929
Schistosoma mansoni	cathepsin C	0.0072	0.036	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0626	0.3856	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0059	0.02
Leishmania major	cathepsin L-like protease	0.0316	0.1901	1
Leishmania major	cysteine peptidase A (CPA)	0.0316	0.1901	1
Toxoplasma gondii	cathepsin B	0.0244	0.1441	0.7576
Schistosoma mansoni	retinoic acid receptor RXR	0.0032	0.0108	0.0281
Giardia lamblia	Hypothetical protein	0.0072	0.036	0.2386
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0012	0.003
Echinococcus multilocularis	fibrillin 1	0.0016	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0032	0.0108	0.0281
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0108	0.0281
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.036	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0072	0.036	0.0934
Schistosoma mansoni	ap endonuclease	0.0019	0.0021	0.0055
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0217	0.1276	0.3272
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0072	0.036	0.1802
Echinococcus granulosus	tumor protein p63	0.0331	0.199	0.5161
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0072	0.036	0.0934
Onchocerca volvulus	Arrow homolog	0.0016	0.0005	0.0027
Echinococcus granulosus	polycomb protein SCMH1	0.0094	0.0496	0.1285
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0032	0.0108	0.0281
Schistosoma mansoni	hypothetical protein	0.0021	0.0038	0.0097
Brugia malayi	steroid hormone receptor	0.0032	0.0108	0.0281
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0013
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0059	0.02
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0032	0.0108	0.0281
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0072	0.036	0.0934
Toxoplasma gondii	cathepsin CPL	0.0316	0.1901	1
Brugia malayi	mbt repeat family protein	0.0094	0.0496	0.1285
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0496	0.1285
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0072	0.036	0.1802
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0072	0.036	0.0934
Entamoeba histolytica	cysteine proteinase, putative	0.0171	0.0985	0.5126
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0016	0.0005	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.036	0.1802
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0099	0.0528	0.1369
Trypanosoma cruzi	cysteine peptidase, putative	0.0316	0.1901	0.4901
Loa Loa (eye worm)	cathepsin B	0.0244	0.1441	0.3738
Entamoeba histolytica	cysteine protease, putative	0.0316	0.1901	1
Entamoeba histolytica	cysteine proteinase, putative	0.0316	0.1901	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0094	0.0496	0.1285
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0072	0.036	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0209	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0072	0.036	0.0934
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0032	0.0108	0.0281
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0316	0.1901	0.4929
Brugia malayi	Papain family cysteine protease containing protein	0.0171	0.0985	0.2553
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0108	0.0281
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0072	0.036	0.1802
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0021	0.5
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0072	0.036	0.1802
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0032	0.0108	0.0281
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0032	0.0108	0.0281
Brugia malayi	hypothetical protein	0.0017	0.0012	0.003
Brugia malayi	Kringle domain containing protein	0.0021	0.0038	0.0097
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0032	0.0108	0.0281
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0316	0.1901	0.4929
Brugia malayi	Papain family cysteine protease containing protein	0.0072	0.036	0.0934
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Echinococcus granulosus	cathepsin L	0.0171	0.0985	0.2553
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0072	0.036	0.1802
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Giardia lamblia	Cathepsin L-like protease	0.0072	0.036	0.2386
Brugia malayi	ecdysteroid receptor	0.0032	0.0108	0.0281
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0032	0.0108	0.0281
Schistosoma mansoni	egf-like domain protein	0.0016	0.0005	0.0013
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0108	0.0281
Plasmodium vivax	vivapain-3	0.0171	0.0985	0.5126
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0072	0.036	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0072	0.036	0.0934
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0012	0.003
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0021	0.0038	0.0087
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0244	0.1441	0.7555
Plasmodium vivax	serine-repeat antigen (SERA)	0.0072	0.036	0.1802
Echinococcus multilocularis	tissue type plasminogen activator	0.0021	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0108	0.0281
Onchocerca volvulus		0.0217	0.1276	0.6714
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0032	0.0108	0.0281
Giardia lamblia	Cathepsin L precursor	0.0072	0.036	0.2386
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0072	0.036	0.0934
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0021	0.5
Loa Loa (eye worm)	fibroinase	0.0316	0.1901	0.4929
Plasmodium vivax	unspecified product	0.0171	0.0985	0.5126
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0032	0.0108	0.0281
Entamoeba histolytica	cysteine proteinase 1, putative	0.0171	0.0985	0.5126
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0316	0.1901	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0108	0.0281
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0641	0.1661
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0032	0.0108	0.0281
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0072	0.036	0.0934
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0072	0.036	0.0934
Schistosoma mansoni	cathepsin S (C01 family)	0.0072	0.036	0.0934
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0016	0.0005	0.0013
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0107	0.0577	0.1498
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0094	0.0496	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0012	0.003
Trypanosoma cruzi	cysteine peptidase, putative	0.0171	0.0985	0.2512
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0528	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0528	0.1369
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.036	0.1802
Giardia lamblia	Cathepsin L precursor	0.0072	0.036	0.2386
Giardia lamblia	Cysteine protease	0.0072	0.036	0.2386
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0016	0.0005	0.0013
Schistosoma mansoni	cathepsin s	0.0099	0.0528	0.1369
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0059	0.02
Trypanosoma cruzi	cruzipain precursor, putative	0.0099	0.0528	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0013
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0032	0.0108	0.0281
Echinococcus granulosus	ecdysone induced protein 78C	0.0032	0.0108	0.0281
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0032	0.0108	0.0281
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0108	0.0281
Echinococcus granulosus	cathepsin L cysteine protease	0.0171	0.0985	0.2553
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0626	0.3856	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0072	0.036	0.1802
Plasmodium vivax	serine-repeat antigen (SERA)	0.0072	0.036	0.1802
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0021	0.0038	0.0097
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0316	0.1901	0.1901
Onchocerca volvulus		0.0316	0.1901	1
Giardia lamblia	Cathepsin B precursor	0.0244	0.1441	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0316	0.1901	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0171	0.0985	0.5126
Trypanosoma cruzi	cysteine proteinase, putative	0.0171	0.0985	0.2512
Trypanosoma cruzi	cysteine protease, putative	0.0171	0.0985	0.2512
Trypanosoma cruzi	cysteine peptidase, putative	0.0099	0.0528	0.1321
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1276	0.6677
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0021	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0012	0.003
Schistosoma mansoni	coup transcription factor	0.0032	0.0108	0.0281
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0316	0.1901	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0032	0.0108	0.057
Plasmodium vivax	unspecified product	0.0099	0.0528	0.2695
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0171	0.0985	0.5126
Plasmodium vivax	vivapain-2	0.0316	0.1901	1
Giardia lamblia	Cathepsin L precursor	0.0072	0.036	0.2386
Plasmodium vivax	vivapain-1	0.0171	0.0985	0.5126
Schistosoma mansoni	cathepsin F (C01 family)	0.0316	0.1901	0.4929
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.036	0.1802
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.0108	0.0281
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0072	0.036	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0059	0.0153
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.036	0.1802
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0072	0.036	0.0934
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0626	0.3856	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0017	0.0012	0.003
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0316	0.1901	0.4929
Giardia lamblia	Cathepsin L precursor	0.0072	0.036	0.2386
Brugia malayi	Papain family cysteine protease containing protein	0.0171	0.0985	0.2553
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0626	0.3856	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0072	0.036	0.0934
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0626	0.3856	1
Toxoplasma gondii	cathepsin CPC2	0.0072	0.036	0.1872
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0059	0.02
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0072	0.036	0.2386
Echinococcus granulosus	laminin	0.0016	0.0005	0.0013
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0107	0.0577	0.0577
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0217	0.1276	0.6677
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1036	0.2687
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1276	0.3309
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Loa Loa (eye worm)	hypothetical protein	0.0072	0.036	0.0934
Entamoeba histolytica	cysteine proteinase, putative	0.0171	0.0985	0.5126
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0032	0.0108	0.0281
Entamoeba histolytica	cysteine proteinase, putative	0.0171	0.0985	0.5126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0316	0.1901	1
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Entamoeba histolytica	cysteine proteinase, putative	0.0217	0.1276	0.6677
Echinococcus granulosus	Tolloid protein 1	0.0016	0.0005	0.0013
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0072	0.036	0.0934
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0107	0.0577	0.1498
Brugia malayi	N-terminal motif family protein	0.0179	0.1036	0.2687
Echinococcus multilocularis	cysteine protease	0.0316	0.1901	0.1901
Echinococcus granulosus	cathepsin l1	0.0316	0.1901	0.4929
Brugia malayi	Calcium binding EGF domain containing protein	0.0016	0.0005	0.0013
Onchocerca volvulus	Cathepsin L homolog	0.0072	0.036	0.1894
Brugia malayi	nuclear receptor NHR-88	0.0032	0.0108	0.0281
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0107	0.0577	0.0577
Echinococcus granulosus	tissue type plasminogen activator	0.0021	0.0038	0.0097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0032	0.0108	0.0281
Brugia malayi	cathepsin L-like cysteine proteinase	0.0072	0.036	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0013
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0038	0.0097
Loa Loa (eye worm)	ctsf protein	0.0316	0.1901	0.4929
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0171	0.0985	0.2553
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0316	0.1901	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0316	0.1901	0.4901
Leishmania major	cathepsin L-like protease	0.0316	0.1901	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0626	0.3856	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0316	0.1901	1
Plasmodium vivax	unspecified product	0.0072	0.036	0.1802
Schistosoma mansoni	cathepsin F (C01 family)	0.0217	0.1276	0.3309
Giardia lamblia	Cathepsin B precursor	0.0072	0.036	0.2386
Onchocerca volvulus		0.0316	0.1901	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0316	0.1901	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0072	0.036	0.1802
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0021	0.0055
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0316	0.1901	0.4929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.036	0.1802
Brugia malayi	hypothetical protein	0.0025	0.0059	0.0153
Schistosoma mansoni	ap endonuclease	0.0019	0.0021	0.0055
Brugia malayi	cathepsin L-like precursor	0.0217	0.1276	0.3309
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0072	0.036	0.1802
Plasmodium falciparum	serine repeat antigen 1	0.0072	0.036	0.1802
Brugia malayi	cathepsin F-like cysteine proteinase	0.0099	0.0528	0.1369
Plasmodium falciparum	cysteine repeat modular protein 1	0.0021	0.0038	0.0087
Brugia malayi	Papain family cysteine protease containing protein	0.0072	0.036	0.0934
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0032	0.0108	0.0108
Brugia malayi	Cathepsin L-like precursor	0.0316	0.1901	0.4929
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0316	0.1901	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0626	0.3856	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0316	0.1901	0.1901
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0032	0.0108	0.0108
Schistosoma mansoni	RAR-like nuclear receptor	0.0032	0.0108	0.0281
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Giardia lamblia	Cysteine protease	0.0072	0.036	0.2386
Echinococcus granulosus	cysteine protease	0.0171	0.0985	0.2553
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0373	0.2261	0.5864
Brugia malayi	hypothetical protein	0.0016	0.0004	0.001
Echinococcus granulosus	histone acetyltransferase MYST2	0.0107	0.0577	0.1498
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0032	0.0108	0.0281
Brugia malayi	Cathepsin L-like precursor	0.0217	0.1276	0.3309
Giardia lamblia	Cathepsin B precursor	0.0244	0.1441	1
Plasmodium vivax	vivapain-2	0.0316	0.1901	1
Leishmania major	cathepsin L-like protease	0.0316	0.1901	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0059	0.0284
Loa Loa (eye worm)	cysteine protease	0.0316	0.1901	0.4929
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0108	0.0281
Entamoeba histolytica	cysteine proteinase 2	0.0171	0.0985	0.5126
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0316	0.1901	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0108	0.0281
Brugia malayi	cathepsin F-like cysteine proteinase	0.0072	0.036	0.0934
Onchocerca volvulus		0.0316	0.1901	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0005	0.0013
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.036	0.1802
Trypanosoma cruzi	cruzipain precursor, putative	0.0316	0.1901	0.4901
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0373	0.2261	0.2261
Brugia malayi	photoreceptor-specific nuclear receptor	0.0032	0.0108	0.0281
Echinococcus granulosus	FTZ F1 alpha	0.0032	0.0108	0.0281
Plasmodium falciparum	serine repeat antigen 8	0.0072	0.036	0.1802
Plasmodium falciparum	serine repeat antigen 3	0.0072	0.036	0.1802
Echinococcus multilocularis	laminin	0.0016	0.0005	0.0005
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0316	0.1901	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1
Entamoeba histolytica	cysteine protease, putative	0.0072	0.036	0.1802
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0641	0.1661
Brugia malayi	Cathepsin L-like precursor	0.0217	0.1276	0.3309
Entamoeba histolytica	cysteine protease, putative	0.0171	0.0985	0.5126
Echinococcus multilocularis	FTZ F1 alpha	0.0032	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0108	0.0281
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0072	0.036	0.1802
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0316	0.1901	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0244	0.1441	0.3738
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0059	0.02
Entamoeba histolytica	cysteine proteinase, putative	0.0171	0.0985	0.5126
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0244	0.1441	0.7555
Onchocerca volvulus		0.0072	0.036	0.1894
Echinococcus multilocularis	ecdysone induced protein 78C	0.0032	0.0108	0.0108
Entamoeba histolytica	cysteine protease, putative	0.0072	0.036	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0038	0.0097
Plasmodium falciparum	serine repeat antigen 2	0.0072	0.036	0.1802
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0032	0.0108	0.0281
Brugia malayi	mbt repeat family protein	0.0094	0.0496	0.1285
Onchocerca volvulus		0.0316	0.1901	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0108	0.0281
Onchocerca volvulus		0.0048	0.0209	0.1098
Loa Loa (eye worm)	mbt repeat family protein	0.0094	0.0496	0.1285
Plasmodium falciparum	serine repeat antigen 6	0.0072	0.036	0.1802
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0032	0.0108	0.0281
Brugia malayi	Cathepsin L-like precursor	0.0316	0.1901	0.4929
Entamoeba histolytica	cysteine protease, putative	0.0072	0.036	0.1802
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0316	0.1901	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0012	0.003
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0032	0.0108	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0032	0.0108	0.0281
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0316	0.1901	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 300 uM	Displacement of biotinylated fibrinogen from human glycoprotein 2b/3a receptor after 2 hrs by chemiluminescence assay	ChEMBL.	23644213

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2391036

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1781203