Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Mus musculus | prostaglandin-endoperoxide synthase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0079 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0095 uM | Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassay | ChEMBL. | 23680444 |
IC50 (binding) | > 10 uM | Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to substrate addition measured after 30 mins by radioimmunoassay | ChEMBL. | 23680444 |
Inhibition (functional) | = 44 % | Analgesic activity in Swiss albino mouse inflammatory pain model assessed as inhibition of acetic acid-induced writhing at 20 mg/kg, po administered 30 mins prior to acetic acid challenge relative to vehicle-treated control | ChEMBL. | 23680444 |
Ratio IC50 (binding) | = 8 | Ratio of celecoxib IC50 to compound IC50 for COX2 in mouse J774 cells | ChEMBL. | 23680444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.