Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0237 | 0.462 | 0.462 |
Leishmania major | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0237 | 0.462 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0109 | 0.1578 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0237 | 0.462 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0043 | 0 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Plasmodium falciparum | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0237 | 0.462 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0043 | 0 | 0.5 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0043 | 0 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MBC (functional) | = 16 mg/ml | Bactericidal activity against Escherichia coli ATCC 10536 by broth dilution method | ChEMBL. | 23669354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.