Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0136 | 0.0136 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0106 | 0.0106 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0829 | 0.3803 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0943 | 0.4328 | 0.4324 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0106 | 0.0106 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0506 | 0.231 | 0.231 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0943 | 0.4328 | 0.4328 |
Echinococcus multilocularis | 0.0014 | 0.0032 | 0.0032 | |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0943 | 0.4328 | 0.4324 |
Trypanosoma brucei | cytochrome P450, putative | 0.0023 | 0.0072 | 0.0106 |
Schistosoma mansoni | tyrosine kinase | 0.0506 | 0.231 | 0.231 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2169 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0023 | 0.0072 | 0.0106 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0301 | 0.1361 | 0.1354 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0136 | 0.0129 |
Schistosoma mansoni | tyrosine kinase | 0.0301 | 0.1361 | 0.1361 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0008 | 0.0008 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0458 | 0.2084 | 0.2084 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0136 | 0.0276 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2169 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.0099 | 0.5 | |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0136 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0301 | 0.1361 | 0.1361 |
Echinococcus granulosus | dnaJ subfamily B | 0.0405 | 0.184 | 0.184 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0136 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2169 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0014 | 0.0032 | 0.0032 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0136 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0136 | 0.0276 |
Echinococcus multilocularis | insulin receptor | 0.0301 | 0.1361 | 0.1361 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.0119 | 0.0087 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0023 | 0.0072 | 0.004 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.0207 | 0.02 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0301 | 0.1361 | 0.1361 |
Schistosoma mansoni | tyrosine kinase | 0.0501 | 0.2286 | 0.2286 |
Schistosoma mansoni | tyrosine kinase | 0.0943 | 0.4328 | 0.4328 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0458 | 0.2084 | 0.2084 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.0216 | 0.0489 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0683 | 0.3126 | 0.3126 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0136 | 0.0276 |
Schistosoma mansoni | tyrosine kinase | 0.0501 | 0.2286 | 0.2286 |
Echinococcus granulosus | neuropeptide s receptor | 0.0458 | 0.2084 | 0.2084 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0829 | 0.3803 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.0207 | 0.0199 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0106 | 0.0106 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0136 | 0.0136 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.0246 | 0.0246 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0132 | 0.0125 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0032 | 0.0025 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0506 | 0.231 | 0.231 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0132 | 0.0132 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0072 | 0.0106 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0829 | 0.3803 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0136 | 0.0276 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0072 | 0.0065 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0136 | 0.0276 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0506 | 0.231 | 0.231 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0301 | 0.1361 | 0.1361 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0023 | 0.0072 | 0.0065 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0458 | 0.2084 | 0.2084 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0072 | 0.0065 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0099 | 0.0091 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0008 | 0.0008 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0106 | 0.0106 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0132 | 0.0132 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0072 | 0.0065 |
Echinococcus multilocularis | 0.0292 | 0.1317 | 0.1317 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0943 | 0.4328 | 0.4328 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0136 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0136 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0014 | 0.0032 | 0.0032 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0132 | 0.0132 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0829 | 0.3803 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0405 | 0.184 | 0.184 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2169 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2169 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.2169 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2169 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2169 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0136 | 0.0129 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0136 | 0.0136 |
Schistosoma mansoni | tyrosine kinase | 0.0501 | 0.2286 | 0.2286 |
Schistosoma mansoni | tyrosine kinase | 0.0506 | 0.231 | 0.231 |
Brugia malayi | cytochrome P450 | 0.0014 | 0.0032 | 0.0025 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0008 | 0.0001 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0072 | 0.0106 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0072 | 0.0065 |
Loa Loa (eye worm) | cytochrome P450 | 0.0014 | 0.0032 | 0.0025 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0136 | 0.0136 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0683 | 0.3126 | 0.3126 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0829 | 0.3803 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0132 | 0.0132 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0829 | 0.3803 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.0136 | 0.0105 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.0119 | 0.0087 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0099 | 0.0091 |
Brugia malayi | Dihydrofolate reductase | 0.2169 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0683 | 0.3126 | 0.3126 |
Echinococcus granulosus | insulin receptor | 0.0301 | 0.1361 | 0.1361 |
Brugia malayi | Protein kinase domain containing protein | 0.0301 | 0.1361 | 0.1354 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0405 | 0.184 | 0.184 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | > 50 % | Inhibition of human recombinant GSK3beta using pIRS-1 (RREGGMSRPAS(p)VDG) as substrate assessed as residual activity at 10 uM after 15 mins in presence of 32P[gamma-ATP] | ChEMBL. | 22749643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.