Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Homo sapiens | glycogen synthase kinase 3 alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0535 | 0.3265 | 1 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0535 | 0.3265 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.14 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0535 | 0.3265 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0535 | 0.3265 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0535 | 0.3265 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.14 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.14 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.14 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.14 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.14 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0535 | 0.3265 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.14 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.14 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0116 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.14 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.003 uM | Inhibition of human recombinant GSK3alpha by FRET assay | ChEMBL. | 22749643 |
IC50 (binding) | = 0.027 uM | Inhibition of human recombinant GSK3beta by FRET assay | ChEMBL. | 22749643 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant PKCalpha by FRET assay | ChEMBL. | 22749643 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant AURKA by FRET assay | ChEMBL. | 22749643 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant CK1epsilon by FRET assay | ChEMBL. | 22749643 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant Cdk5/p35 by FRET assay | ChEMBL. | 22749643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.