Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | p450 reductase, putative | 0.0418 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0258 | 0.2407 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0258 | 0.2407 | 0.2407 |
Trypanosoma cruzi | p450 reductase, putative | 0.0418 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0258 | 0.2407 | 0.0615 |
Echinococcus multilocularis | methionine synthase reductase | 0.0258 | 0.2407 | 0.0615 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0418 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0418 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0208 | 0 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0418 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0418 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0418 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0371 | 0.7743 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0418 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0371 | 0.7743 | 0.7211 |
Brugia malayi | FAD binding domain containing protein | 0.0258 | 0.2407 | 0.0615 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0211 | 0.0151 | 0.0151 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0418 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0258 | 0.2407 | 0.0615 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0418 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0418 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0418 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.191 | 0.191 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0418 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0208 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.191 | 0.191 |
Giardia lamblia | Hypothetical protein | 0.0371 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0418 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0418 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0418 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0418 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0418 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.61 nM | Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay | ChEMBL. | 23842519 |
Ki (binding) | = 0.7 nM | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins to 6 hrs by CO2 hydration stopped-flow assay | ChEMBL. | 23815159 |
Ki (binding) | = 0.7 nM | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 10 mins by CO2 hydration stopped-flow assay | ChEMBL. | 23842519 |
Ki (binding) | = 0.74 nM | Inhibition of human recombinant carbonic anhydrase 12 preincubated for 10 mins by CO2 hydration stopped-flow assay | ChEMBL. | 23842519 |
Ki (binding) | = 7.6 nM | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins to 6 hrs by CO2 hydration stopped-flow assay | ChEMBL. | 23815159 |
Ki (binding) | = 7.6 nM | Inhibition of human recombinant carbonic anhydrase 1 preincubated for 10 mins by CO2 hydration stopped-flow assay | ChEMBL. | 23842519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.