Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.007 | 0.208 | 0.1879 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.4389 | 0.4389 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0188 | 0.779 | 0.7734 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0188 | 0.779 | 0.7734 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0188 | 0.779 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0188 | 0.779 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0188 | 0.779 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0073 | 0.223 | 0.223 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0188 | 0.779 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0392 | 0.019 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0249 | 0.0249 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0188 | 0.779 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0073 | 0.223 | 0.223 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0249 | 0.0249 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0188 | 0.779 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1057 | 0.1057 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0392 | 0.0147 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.4389 | 0.4246 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.208 | 0.2429 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0073 | 0.223 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0073 | 0.223 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0188 | 0.779 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0301 | 0.0301 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1057 | 0.0829 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1057 | 0.1057 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 1 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0979 | 0.0969 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0301 | 0.0053 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0188 | 0.779 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0188 | 0.779 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0073 | 0.223 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0188 | 0.779 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0188 | 0.779 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0073 | 0.223 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0979 | 0.0749 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0073 | 0.223 | 0.223 |
Onchocerca volvulus | 0.0048 | 0.0979 | 0.3988 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0073 | 0.223 | 0.223 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.4389 | 0.4389 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0301 | 0.0069 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Onchocerca volvulus | 0.007 | 0.208 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0392 | 0.0392 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0073 | 0.223 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0249 | 0.0249 |
Leishmania major | dihydroorotate dehydrogenase | 0.0188 | 0.779 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1057 | 0.0829 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0073 | 0.223 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.0249 | 0.0249 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0979 | 0.0969 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0392 | 0.019 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0073 | 0.223 | 0.2032 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.007 | 0.208 | 0.208 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0188 | 0.779 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0073 | 0.223 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0392 | 0.0392 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 80 % | Inhibition of atypical PKCzeta (unknown origin) using CREBtide as substrate at 30 uM incubated for 1 hr measured every 2.5 mins by ADP Quest assay relative to control | ChEMBL. | 23566515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.