Detailed information for compound 1782583

Basic information

Technical information
  • TDR Targets ID: 1782583
  • Name: di(phenyl)boranyloxy-di(phenyl)borane
  • MW: 346.037 | Formula: C24H20B2O
  • H donors: 0 H acceptors: 0 LogP: 7.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O(B(c1ccccc1)c1ccccc1)B(c1ccccc1)c1ccccc1
  • InChi: 1S/C24H20B2O/c1-5-13-21(14-6-1)25(22-15-7-2-8-16-22)27-26(23-17-9-3-10-18-23)24-19-11-4-12-20-24/h1-20H
  • InChiKey: SNQFEECGHGUHBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 358835_ALDRICH
  • Oxybis(diphenylborane)
  • Tetraphenyldiboroxane
  • 42815_FLUKA
  • 1,1,3,3-Tetraphenyldiboroxane
  • Diphenylborinic anhydride
  • InChI=1/C24H20B2O/c1-5-13-21(14-6-1)25(22-15-7-2-8-16-22)27-26(23-17-9-3-10-18-23)24-19-11-4-12-20-24/h1-20

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ORAI calcium release-activated calcium modulator 2 Starlite/ChEMBL References
Homo sapiens transient receptor potential cation channel, subfamily V, member 6 Starlite/ChEMBL References
Homo sapiens ORAI calcium release-activated calcium modulator 3 Starlite/ChEMBL References
Homo sapiens ORAI calcium release-activated calcium modulator 1 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi hypothetical protein Get druggable targets OG5_130743 All targets in OG5_130743
Brugia malayi olfactory channel protein osm-9 Get druggable targets OG5_131423 All targets in OG5_131423
Echinococcus granulosus calcium release activated calcium channel Get druggable targets OG5_130743 All targets in OG5_130743
Schistosoma mansoni Protein orai-1 Get druggable targets OG5_130743 All targets in OG5_130743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131423 All targets in OG5_131423
Echinococcus multilocularis calcium release activated calcium channel Get druggable targets OG5_130743 All targets in OG5_130743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130743 All targets in OG5_130743
Schistosoma mansoni Protein orai-1 Get druggable targets OG5_130743 All targets in OG5_130743
Schistosoma japonicum IPR012446,Protein of unknown function DUF1650,domain-containing Get druggable targets OG5_130743 All targets in OG5_130743
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi TRP channel protein nanchung transient receptor potential cation channel, subfamily V, member 6 725 aa 595 aa 27.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0236 0.0236
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.034 0.89
Schistosoma mansoni hypothetical protein 0.0033 0.0167 0.0167
Leishmania major cathepsin L-like protease 0.0016 0.0047 0.0651
Trichomonas vaginalis ap endonuclease, putative 0.002 0.007 0.0392
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.068 0.0715
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0047 0.0047
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0184 0.0193
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0047 0.0291
Schistosoma mansoni alpha-glucosidase 0.0137 0.0918 0.0918
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0248
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0024 0.0099
Brugia malayi Cathepsin L-like precursor 0.0016 0.0047 0.0049
Echinococcus granulosus GPCR family 2 0.0033 0.0167 0.0167
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0041 0.0041
Plasmodium vivax SET domain protein, putative 0.003 0.0148 0.0223
Leishmania major cathepsin L-like protease 0.0062 0.0379 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Brugia malayi Pre-SET motif family protein 0.003 0.0148 0.0156
Echinococcus multilocularis cpg binding protein 0.0061 0.0372 0.0372
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0184 0.1099
Brugia malayi Cathepsin L-like precursor 0.0016 0.0047 0.0049
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1078 0.1078
Leishmania major UDP-galactopyranose mutase 0.0042 0.0236 0.5983
Brugia malayi cathepsin L-like precursor 0.0011 0.0008 0.0008
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0515 0.0515
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0048 0.0278 0.0292
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0024 0.0099
Entamoeba histolytica cysteine protease, putative 0.0016 0.0047 0.074
Schistosoma mansoni Protein orai-1 0.1323 0.9513 0.9513
Onchocerca volvulus 0.0016 0.0047 0.0291
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0348 0.0366
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0047 0.0049
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0379 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0605 0.0636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0248
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0047 0.0049
Leishmania major cathepsin L-like protease 0.0062 0.0379 1
Schistosoma mansoni hypothetical protein 0.0824 0.5898 0.5898
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0094 0.0051
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0047 0.0047
Schistosoma mansoni cpg binding protein 0.0058 0.0348 0.0348
Schistosoma mansoni hypothetical protein 0.0033 0.0167 0.0167
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0515 0.0515
Loa Loa (eye worm) ctsf protein 0.0016 0.0047 0.0049
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0066 0.007
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0042 0.0236 0.0416
Entamoeba histolytica fatty acid elongase, putative 0.0084 0.0535 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0047 0.0049
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0148 0.1486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Onchocerca volvulus 0.0232 0.1611 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0064 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0047 0.0244
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0042 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0047 0.0244
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0184 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0184 0.4508
Chlamydia trachomatis protoporphyrinogen oxidase 0.0042 0.0236 0.0316
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0094 0.0103
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0645 0.46 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0099
Echinococcus multilocularis GPCR, family 2 0.0033 0.0167 0.0167
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0184 0.2003
Entamoeba histolytica fatty acid elongase, putative 0.0084 0.0535 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0515 0.0542
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0047 0.0244
Schistosoma mansoni Protein orai-1 0.1323 0.9513 0.9513
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0603 0.4294 0.9325
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.007 0.1318
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0236 0.0416
Echinococcus multilocularis microtubule associated protein 2 0.139 1 1
Leishmania major cathepsin L-like protease 0.0016 0.0047 0.0651
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0047 0.074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0047 0.0244
Brugia malayi Cathepsin L-like precursor 0.0011 0.0008 0.0008
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0645 0.46 1
Trypanosoma brucei glucosidase, putative 0.0035 0.0184 0.4508
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.0099
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0094 0.0685
Mycobacterium ulcerans oxidoreductase 0.0042 0.0236 0.0366
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0024 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0024 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0184 0.4508
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0041 0.0041
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1078 0.1078
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0184 0.1099
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0236 0.0236
Brugia malayi SWIRM domain containing protein 0.0042 0.0236 0.0248
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.007 0.1318
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0603 0.4294 0.9325
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0099
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0184 0.3335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0379 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.0099
Leishmania major cathepsin L-like protease 0.0016 0.0047 0.0651
Toxoplasma gondii histone lysine-specific demethylase 0.0042 0.0236 0.2769
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0024 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0148 0.0148
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0042 0.0236 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0148 0.0148
Schistosoma mansoni alpha-glucosidase 0.0137 0.0918 0.0918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Onchocerca volvulus 0.0016 0.0047 0.0291
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0024 0.0302
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1406 0.1478
Brugia malayi Cathepsin L-like precursor 0.0016 0.0047 0.0049
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0094 0.1971
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0094 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.0236 0.0416
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0148 0.0148
Echinococcus multilocularis calcium release activated calcium channel 0.1323 0.9513 0.9513
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0184 0.3335
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0132 0.0132
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0094 0.0103
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0094 0.0051
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0148 0.0148
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0094 0.1971
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0099
Onchocerca volvulus 0.0058 0.0348 0.216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Brugia malayi CXXC zinc finger family protein 0.0058 0.0348 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0047 0.0244
Mycobacterium tuberculosis Possible oxidoreductase 0.0042 0.0236 0.0366
Brugia malayi hypothetical protein 0.0042 0.0236 0.0248
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0184 0.1099
Trichomonas vaginalis helicase, putative 0.0013 0.0024 0.0099
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.1078 0.1078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0248
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0047 0.0047
Schistosoma mansoni amine oxidase 0.0042 0.0236 0.0236
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.1078 0.1133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0825 0.0825
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Schistosoma mansoni cpg binding protein 0.0061 0.0372 0.0372
Leishmania major cathepsin L-like protease 0.0016 0.0047 0.0651
Schistosoma mansoni alpha glucosidase 0.0035 0.0184 0.0184
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0167 0.0167
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0008 0.0008
Schistosoma mansoni amine oxidase 0.0042 0.0236 0.0236
Echinococcus multilocularis protoporphyrinogen oxidase 0.0042 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0248
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0041 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.0099
Entamoeba histolytica hypothetical protein 0.0023 0.0094 0.1628
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0024 0.0099
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0645 0.46 1
Toxoplasma gondii exonuclease III APE 0.002 0.007 0.0346
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0515 0.0542
Schistosoma mansoni ap endonuclease 0.002 0.007 0.007
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0184 0.1099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Echinococcus granulosus calcium release activated calcium channel 0.1323 0.9513 0.9513
Onchocerca volvulus 0.0016 0.0047 0.0291
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0167 0.0175
Echinococcus multilocularis tumor protein p63 0.0329 0.2313 0.2313
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0047 0.0291
Echinococcus multilocularis dnaJ subfamily B 0.0824 0.5898 0.5898
Brugia malayi Pre-SET motif family protein 0.0204 0.1406 0.1478
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.007 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Schistosoma mansoni hypothetical protein 0.0033 0.0167 0.0167
Onchocerca volvulus 0.003 0.0148 0.0922
Schistosoma mansoni hypothetical protein 0.0071 0.0443 0.0443
Onchocerca volvulus 0.0081 0.0515 0.3199
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.0099
Echinococcus granulosus cpg binding protein 0.0061 0.0372 0.0372
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0042 0.0236 0.0236
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0047 0.0651
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0236 0.5983
Onchocerca volvulus 0.0048 0.0278 0.1724
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0047 0.0244
Echinococcus multilocularis 0.0042 0.0236 0.0236
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0047 0.0047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0236 0.0366
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0042 0.0236 0.0236
Onchocerca volvulus 0.0016 0.0047 0.0291
Brugia malayi Cathepsin L-like precursor 0.0011 0.0008 0.0008
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0184 0.4508
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0024 0.0025
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0094 0.0051
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0024 0.0099
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0041 0.0041
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.007 0.1318
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0184 0.1099
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0167 0.0175
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.1323 0.9513 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0248
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.007 0.1189
Brugia malayi Cathepsin L-like precursor 0.0016 0.0047 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0047 0.0244
Entamoeba histolytica fatty acid elongase, putative 0.0084 0.0535 1
Echinococcus granulosus dnaJ subfamily B 0.0824 0.5898 0.5898
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Onchocerca volvulus 0.0092 0.0593 0.3685
Onchocerca volvulus 0.0016 0.0047 0.0291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0248
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0047 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.068 0.0715
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0099
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0024 0.0099
Mycobacterium ulcerans monoamine oxidase 0.0042 0.0236 0.0366
Brugia malayi amine oxidase, flavin-containing family protein 0.0042 0.0236 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0099
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.056 0.3987 0.8646
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0184 0.1099
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0645 0.46 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.007 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0049
Brugia malayi Cathepsin L-like precursor 0.0016 0.0047 0.0049
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0167 0.0175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0024 0.0099
Onchocerca volvulus 0.0016 0.0047 0.0291
Echinococcus granulosus tumor protein p63 0.0329 0.2313 0.2313
Echinococcus multilocularis cysteine protease 0.0016 0.0047 0.0047
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0645 0.46 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Schistosoma mansoni cpg binding protein 0.0061 0.0372 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0099
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0184 0.1099
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.007 0.1318
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0094 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0379 1
Entamoeba histolytica fatty acid elongase, putative 0.0084 0.0535 1
Loa Loa (eye worm) fibroinase 0.0016 0.0047 0.0049
Schistosoma mansoni microtubule-associated protein tau 0.139 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0443 0.0465
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0046 0.0262 0.3143
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.007 0.007
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0024 0.0099
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0236 0.5983
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0731 1
Onchocerca volvulus 0.0016 0.0047 0.0291
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0042 0.0236 0.0416
Loa Loa (eye worm) cysteine protease 0.0016 0.0047 0.0049
Entamoeba histolytica fatty acid elongase, putative 0.0084 0.0535 1
Plasmodium falciparum protoporphyrinogen oxidase 0.0042 0.0236 0.0416
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Loa Loa (eye worm) hypothetical protein 0.0104 0.068 0.0715
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0094 0.0685
Schistosoma mansoni hypothetical protein 0.0033 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0047 0.0291
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0184 0.0184
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0047 0.0244
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0184 0.1099
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0379 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0066 0.0066
Leishmania major cathepsin L-like protease 0.0016 0.0047 0.0651
Onchocerca volvulus 0.0011 0.0008 0.0048
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0184 0.1099
Onchocerca volvulus 0.0042 0.0236 0.1466
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.007 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0099
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0278 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0024 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.0099
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0047 0.074
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0236 0.0416
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0443 0.0465
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0042 0.0236 0.0366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0379 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0167 0.0167
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.068 0.0715
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0047 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0148 0.0148
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0645 0.46 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0047 0.0244
Leishmania major cathepsin L-like protease 0.0062 0.0379 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0047 0.0244
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0042 0.0236 0.0416
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0184 0.0193
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0175
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.007 0.0052
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0645 0.46 1
Brugia malayi olfactory channel protein osm-9 0.0093 0.0605 0.0636
Brugia malayi hypothetical protein 0.1323 0.9513 1
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0645 0.46 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0047 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.0099
Trichomonas vaginalis ap endonuclease, putative 0.002 0.007 0.0392
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.007 0.0052
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.1078 0.1133
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0047 0.0651
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0047 0.0244
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0047 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0099
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0167 0.0167
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0515 0.0515
Echinococcus multilocularis cysteine protease 0.0016 0.0047 0.0047
Echinococcus granulosus cathepsin l1 0.0016 0.0047 0.0047
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0282 0.7287
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1609 1
Schistosoma mansoni ap endonuclease 0.002 0.007 0.007
Echinococcus granulosus cathepsin l1 0.0011 0.0008 0.0008
Mycobacterium ulcerans dehydrogenase 0.0042 0.0236 0.0366
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0047 0.0047

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 11.4 uM Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx after 10 mins by FLIPR assay in presence of thapsigargin ChEMBL. 23602525
IC50 (binding) = 13.4 uM Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx after 10 mins by FLIPR assay in presence of thapsigargin ChEMBL. 23602525
IC50 (binding) = 17.7 uM Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Cd2+ influx after 5 mins by FLIPR assay ChEMBL. 23602525
IC50 (binding) = 19.2 uM Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Ca2+ influx after 5 mins by FLIPR assay ChEMBL. 23602525

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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