Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0065 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0065 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1443 | 0.1443 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0065 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0065 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 63.39 % | Cytotoxicity against human HT-29 cells assessed as cell viability at 100 uM after 48 hrs by MTT assay relative to control | ChEMBL. | 23602620 |
IC50 (functional) | = 30.2 uM | Antiamoebic activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS assessed as growth inhibition after 72 hrs by microdilution method | ChEMBL. | 23602620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.