Detailed information for compound 1782752

Basic information

Technical information
  • TDR Targets ID: 1782752
  • Name: N1',N3'-bis(3-cyanobenzenecarbothioyl)-N1',N3 '-dimethylpropanedihydrazide
  • MW: 450.537 | Formula: C21H18N6O2S2
  • H donors: 2 H acceptors: 4 LogP: 2.32 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cccc(c1)C(=S)N(NC(=O)CC(=O)NN(C(=S)c1cccc(c1)C#N)C)C
  • InChi: 1S/C21H18N6O2S2/c1-26(20(30)16-7-3-5-14(9-16)12-22)24-18(28)11-19(29)25-27(2)21(31)17-8-4-6-15(10-17)13-23/h3-10H,11H2,1-2H3,(H,24,28)(H,25,29)
  • InChiKey: BJYBXHCSXHIJOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N1',N3'-bis(3-cyanobenzenecarbothioyl)-N1',N3'-dimethyl-propanedihydrazide
  • N1',N3'-bis[(3-cyanophenyl)-thioxomethyl]-N1',N3'-dimethylpropanedihydrazide
  • N1',N3'-bis(3-cyanothiobenzoyl)-N1',N3'-dimethyl-malonohydrazide
  • N1',N3'-bis[(3-cyanophenyl)carbothioyl]-N1',N3'-dimethyl-propanedihydrazide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax CDK-related protein kinase 6, putative 0.043 0.2092 1
Brugia malayi Sugar transporter family protein 0.0101 0.0452 0.0435
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0059 0.036
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0059 0.5182
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0452 0.0435
Plasmodium falciparum protein kinase 7 0.0286 0.1375 0.6542
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0123 0.0779
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0123 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0452 0.0435
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0101 0.0093
Echinococcus granulosus geminin 0.0164 0.0766 0.075
Trypanosoma brucei glucose transporter, putative 0.0031 0.0103 0.8107
Schistosoma mansoni hypothetical protein 0.0015 0.0023 0.0005
Loa Loa (eye worm) hypothetical protein 0.0059 0.0241 0.0233
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.0416 0.0399
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0452 0.0435
Toxoplasma gondii protein kinase, putative 0.0286 0.1375 1
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0103 0.8107
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0101 0.0617
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0121 0.0104
Brugia malayi Carboxylesterase family protein 0.034 0.1645 0.163
Loa Loa (eye worm) hypothetical protein 0.0023 0.0059 0.0051
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0101 0.0404
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.034 0.1645 0.163
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0101 0.0084
Onchocerca volvulus 0.034 0.1645 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0101 0.0617
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0059 0.395
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0452 0.2669
Echinococcus granulosus GPCR family 2 0.0015 0.0023 0.0005
Loa Loa (eye worm) carboxylesterase 0.2015 1 1
Schistosoma mansoni hypothetical protein 0.0015 0.0023 0.0005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0101 0.0084
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0093
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0098 0.0089
Leishmania major glucose transporter, lmgt2 0.0031 0.0103 0.8107
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0098 0.0081
Leishmania major protein kinase, putative 0.0031 0.0101 0.7919
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0452 0.0435
Onchocerca volvulus 0.034 0.1645 1
Schistosoma mansoni transient receptor potential channel 0.0062 0.0257 0.024
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0045 0.0171
Echinococcus multilocularis BC026374 protein (S09 family) 0.034 0.1645 0.163
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.0763 0.3595
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0032 0.1383
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0103 0.0527
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0257 0.024
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0059 0.0042
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0101 0.0404
Schistosoma mansoni hypothetical protein 0.0164 0.0766 0.075
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0103 0.8107
Leishmania major glucose transporter, lmgt1 0.0031 0.0103 0.8107
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0123 1
Echinococcus granulosus BC026374 protein S09 family 0.034 0.1645 0.163
Loa Loa (eye worm) hypothetical protein 0.034 0.1645 0.1638
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0121 0.0104
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0101 0.0404
Trypanosoma brucei glucose transporter, putative 0.0031 0.0103 0.8107
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.0452 0.0435
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0101 0.0093
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0101 0.7919
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.034 0.1645 0.163
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.0416 0.0399
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0023 0.0005
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0098 0.0081
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0098 0.0081
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0103 0.0527
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0098 0.0495
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0023 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Entamoeba histolytica protein kinase, putative 0.0031 0.0101 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0018 0.0106
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0059 0.0308
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0098 1
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0092 0.0074
Plasmodium vivax hexose transporter 0.0101 0.0452 0.2094
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0023 0.0005
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0018 0.0106
Schistosoma mansoni transient receptor potential channel 0.0062 0.0257 0.024
Echinococcus granulosus acetylcholinesterase 0.2015 1 1
Schistosoma mansoni gliotactin 0.034 0.1645 0.163
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.04 0.0383
Echinococcus multilocularis GPCR, family 2 0.0015 0.0023 0.0005
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.034 0.1645 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0101 0.0084
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.04 0.0383
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0121 0.0104
Loa Loa (eye worm) hypothetical protein 0.0032 0.0105 0.0097
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0101 0.0404
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0257 0.024
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0123 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0018 0.0009
Echinococcus multilocularis acetylcholinesterase 0.2015 1 1
Loa Loa (eye worm) hypothetical protein 0.2015 1 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.034 0.1645 0.163
Schistosoma mansoni glucose transport protein 0.0101 0.0452 0.0435
Echinococcus multilocularis neuroligin 0.034 0.1645 0.163
Schistosoma mansoni hypothetical protein 0.0015 0.0023 0.0005
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0018 0.5
Schistosoma mansoni protein kinase 0.0031 0.0101 0.0084
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0103 0.8107
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0023 0.0014
Schistosoma mansoni hypothetical protein 0.0033 0.0111 0.0094
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0018 0.0009
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0123 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0103 0.0527
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0023 0.0005
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0098 0.0081
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Mycobacterium ulcerans carboxylesterase, LipT 0.034 0.1645 1
Schistosoma mansoni protein kinase 0.0031 0.0101 0.0084
Entamoeba histolytica protein kinase, putative 0.0031 0.0101 1
Loa Loa (eye worm) hypothetical protein 0.034 0.1645 0.1638
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0101 0.0404
Trypanosoma brucei glucose transporter, putative 0.0031 0.0103 0.8107
Loa Loa (eye worm) hypothetical protein 0.0094 0.0416 0.0408
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0452 0.0435
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0188 0.017
Loa Loa (eye worm) carboxylesterase 0.034 0.1645 0.1638
Loa Loa (eye worm) hypothetical protein 0.2015 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0101 0.0514
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0042 0.0152
Echinococcus multilocularis acetylcholinesterase 0.2015 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0098 0.0089
Leishmania major glucose transporter, lmgt3 0.0031 0.0103 0.8107
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0101 0.0084
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0103 0.8107
Loa Loa (eye worm) hypothetical protein 0.034 0.1645 0.1638
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.034 0.1645 1
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0101 0.0084
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Loa Loa (eye worm) hypothetical protein 0.034 0.1645 0.1638
Mycobacterium ulcerans sugar transporter 0.0014 0.0018 0.0106
Loa Loa (eye worm) sugar transporter 0.0101 0.0452 0.0444
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0188 0.0179
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0014
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0103 0.8107
Loa Loa (eye worm) sugar transporter 0.0014 0.0018 0.0009
Echinococcus granulosus para nitrobenzyl esterase 0.034 0.1645 0.163
Trypanosoma brucei glucose transporter, putative 0.0031 0.0103 0.8107
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0042 0.0152
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0123 0.051
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0103 0.0527
Plasmodium falciparum protein kinase 6 0.043 0.2092 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0061
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0059 0.0042
Echinococcus multilocularis General substrate transporter 0.0087 0.0381 0.0364
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.034 0.1645 0.163
Onchocerca volvulus 0.034 0.1645 1
Loa Loa (eye worm) carboxylesterase 0.034 0.1645 0.1638
Echinococcus multilocularis para nitrobenzyl esterase 0.034 0.1645 0.163
Brugia malayi Cam kinase protein 1 0.0031 0.0101 0.0084
Trypanosoma brucei glucose transporter, putative 0.0031 0.0103 0.8107
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0111 0.0094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0188 0.017
Trypanosoma cruzi hexose transporter 0.0031 0.0103 0.8107
Loa Loa (eye worm) acetylcholinesterase 1 0.2015 1 1
Brugia malayi Carboxylesterase family protein 0.034 0.1645 0.163
Trypanosoma brucei glucose transporter, putative 0.0031 0.0103 0.8107
Schistosoma mansoni acetylcholinesterase 0.034 0.1645 0.163
Brugia malayi Carboxylesterase family protein 0.2015 1 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0059 0.036
Trichomonas vaginalis spcc417.12 protein, putative 0.034 0.1645 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0103 0.0527
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Echinococcus multilocularis geminin 0.0164 0.0766 0.075
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0103 0.0527
Loa Loa (eye worm) hypothetical protein 0.034 0.1645 0.1638
Schistosoma mansoni glucose transport protein 0.0101 0.0452 0.0435
Schistosoma mansoni hypothetical protein 0.0101 0.0452 0.0435
Schistosoma mansoni protein kinase 0.0031 0.0101 0.0084
Echinococcus multilocularis carboxylesterase 5A 0.2015 1 1
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0059 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0101 0.0404
Brugia malayi Carboxylesterase family protein 0.034 0.1645 0.163
Trypanosoma brucei glucose transporter, putative 0.0031 0.0103 0.8107
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0023 0.0005
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0059 0.0257
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.0416 0.0399
Brugia malayi hypothetical protein 0.034 0.1645 0.163
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0101 0.0084
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0103 0.8107
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0257 0.024
Schistosoma mansoni BC026374 protein (S09 family) 0.034 0.1645 0.163
Schistosoma mansoni transient receptor potential channel 0.0094 0.0416 0.0399
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0123 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.0452 0.3201
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0092 0.0074
Brugia malayi Carboxylesterase family protein 0.034 0.1645 0.163
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0098 0.9253
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0098 0.0081
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0101 0.0617
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2015 1 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0103 0.8107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0112
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.0763 0.5495
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0123 0.051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0059 0.0042
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0452 0.0435
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0101 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0103 0.0527
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0101 0.0084
Echinococcus granulosus family S9 non peptidase ue S09 family 0.034 0.1645 0.163
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0059 0.0042
Trypanosoma brucei glucose transporter 2A 0.0031 0.0103 0.8107
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0101 0.0404
Plasmodium falciparum hexose transporter 0.0101 0.0452 0.2094
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0059 0.395
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0059 0.0201
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0257 0.024
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0059 0.3046
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0452 0.0435
Schistosoma mansoni hypothetical protein 0.0164 0.0766 0.075
Treponema pallidum prolyl-tRNA synthetase 0.0011 0 0.5
Onchocerca volvulus 0.034 0.1645 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0098 0.0081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0111 0.0103
Echinococcus granulosus General substrate transporter 0.0087 0.0381 0.0364
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0059 0.0201
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0059 0.0042
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.034 0.1645 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0101 0.0084
Trypanosoma brucei glucose transporter 1E 0.0031 0.0103 0.8107
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0059 0.395
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0101 0.0404
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0103 0.8107
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0023 0.0005
Echinococcus granulosus neuroligin 0.034 0.1645 0.163
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.0763 0.3595
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Echinococcus granulosus carboxylesterase 5A 0.2015 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0009
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0101 0.0404
Schistosoma mansoni hypothetical protein 0.0015 0.0023 0.0005
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.034 0.1645 0.163
Schistosoma mansoni glucose transport protein 0.0101 0.0452 0.0435
Loa Loa (eye worm) hypothetical protein 0.034 0.1645 0.1638
Echinococcus granulosus acetylcholinesterase 0.2015 1 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0018 0.0106
Mycobacterium tuberculosis Carboxylesterase LipT 0.034 0.1645 1
Loa Loa (eye worm) hypothetical protein 0.034 0.1645 0.1638
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0101 0.0084
Loa Loa (eye worm) hypothetical protein 0.0048 0.0188 0.0179
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0098 1
Onchocerca volvulus 0.034 0.1645 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 97 nM Induction of Hsp70 production in human Ramos cells after 5 hrs by ELISA ChEMBL. 23937981

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23937981

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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