Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbohydrate kinase, thermoresistant glucokinase, putative | 0.0151 | 0.0743 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0694 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0071 | 0 | 0.5 |
Mycobacterium ulcerans | shikimate kinase | 0.1145 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0145 | 0.0694 | 0.9336 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0151 | 0.0743 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0145 | 0.0694 | 0.9336 |
Schistosoma mansoni | shikimate-kinase | 0.0151 | 0.0743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0694 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0145 | 0.0694 | 0.9336 |
Mycobacterium leprae | Shikimate kinase AroK (SK) | 0.1145 | 1 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0145 | 0.0694 | 0.9336 |
Echinococcus granulosus | carbohydrate kinase thermoresistant glucokinase | 0.0151 | 0.0743 | 1 |
Echinococcus multilocularis | carbohydrate kinase, thermoresistant glucokinase | 0.0151 | 0.0743 | 1 |
Onchocerca volvulus | 0.0071 | 0 | 0.5 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0071 | 0 | 0.5 |
Echinococcus granulosus | thermoresistant glucokinase family carbohydrate | 0.0151 | 0.0743 | 1 |
Mycobacterium tuberculosis | Shikimate kinase AroK (SK) | 0.1145 | 1 | 0.5 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0151 | 0.0743 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.424 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.415 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.