Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0027 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0027 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0017 | 0.2407 | 0.2407 |
Brugia malayi | FAD binding domain containing protein | 0.0027 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0014 | 0.0151 | 0.0151 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0024 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0027 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0024 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0027 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0017 | 0.2407 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0027 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0027 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0027 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0027 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0027 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0027 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0027 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0027 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0027 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0027 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0027 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0027 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 881 nM | Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate up to 180 seconds by hemoglobin capture assay | ChEMBL. | 23993333 |
Ki (binding) | = 31410 nM | Inhibition of mouse recombinant iNOS expressed in Escherichia coli using L-arginine as substrate up to 180 seconds by hemoglobin capture assay | ChEMBL. | 23993333 |
Ki (binding) | = 66959 nM | Inhibition of bovine recombinant eNOS expressed in Escherichia coli using L-arginine as substrate up to 180 seconds by hemoglobin capture assay | ChEMBL. | 23993333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.