Detailed information for compound 178468

Basic information

Technical information
  • TDR Targets ID: 178468
  • Name: N-(2-chloro-6-methylphenyl)-8-piperazin-1-yli midazo[1,5-a]quinoxalin-4-amine
  • MW: 392.885 | Formula: C21H21ClN6
  • H donors: 2 H acceptors: 2 LogP: 4.54 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1Nc1nc2ccc(cc2n2c1cnc2)N1CCNCC1)Cl
  • InChi: 1S/C21H21ClN6/c1-14-3-2-4-16(22)20(14)26-21-19-12-24-13-28(19)18-11-15(5-6-17(18)25-21)27-9-7-23-8-10-27/h2-6,11-13,23H,7-10H2,1H3,(H,25,26)
  • InChiKey: YRKWUGDRKCJCON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-chloro-6-methyl-phenyl)-8-piperazin-1-yl-imidazo[1,5-a]quinoxalin-4-amine
  • N-(2-chloro-6-methylphenyl)-8-(1-piperazinyl)-4-imidazo[1,5-a]quinoxalinamine
  • (2-chloro-6-methyl-phenyl)-(8-piperazinoimidazo[1,5-a]quinoxalin-4-yl)amine
  • N-(2-chloro-6-methylphenyl)-8-piperazin-1-ylimidazo[5,1-c]quinoxalin-4-amine
  • N-(2-chloro-6-methyl-phenyl)-8-piperazin-1-yl-imidazo[5,1-c]quinoxalin-4-amine
  • N-(2-chloro-6-methylphenyl)-8-(1-piperazinyl)-4-imidazo[5,1-c]quinoxalinamine
  • (2-chloro-6-methyl-phenyl)-(8-piperazin-1-ylimidazo[5,1-c]quinoxalin-4-yl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FTZ F1 alpha 0.1066 0.3706 0.3706
Onchocerca volvulus Huntingtin homolog 0.0102 0.0314 0.0847
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.001 0.1259
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0111 0.1098
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0044 0.0111 0.0113
Loa Loa (eye worm) STAT protein 0.0045 0.0115 0.0115
Loa Loa (eye worm) intermediate filament protein 0.0045 0.0115 0.0115
Brugia malayi intermediate filament protein 0.0045 0.0115 0.0191
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0081 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.1066 0.3706 0.3706
Echinococcus granulosus intermediate filament protein 0.0045 0.0115 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0111 0.1098
Schistosoma mansoni vav2 0.0045 0.0115 0.0117
Brugia malayi hypothetical protein 0.0045 0.0115 0.019
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0563 0.1937 0.1937
Echinococcus granulosus FTZ F1 alpha 0.1066 0.3706 0.3706
Entamoeba histolytica protein kinase, putative 0.0044 0.0111 0.1098
Brugia malayi tRNA modification GTPase TrmE family protein 0.0045 0.0115 0.019
Echinococcus granulosus SH2 motif 0.0045 0.0115 0.0115
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0044 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Schistosoma mansoni nuclear hormone receptor 0.0503 0.1725 0.1753
Loa Loa (eye worm) nuclear hormone receptor 0.0503 0.1725 0.1725
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0102 0.0315 0.0315
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.0111 0.1098
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0081 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-25 0.1066 0.3706 0.6143
Brugia malayi CXXC zinc finger family protein 0.0029 0.0059 0.0097
Brugia malayi Sex muscle abnormal protein 5 0.009 0.0271 0.0448
Entamoeba histolytica hypothetical protein 0.0044 0.0111 0.1098
Schistosoma mansoni signal transduction protein lnk-related 0.0045 0.0115 0.0117
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.016 0.016
Onchocerca volvulus Putative cortactin 0.0044 0.0111 0.0299
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0045 0.0115 0.0115
Loa Loa (eye worm) MH2 domain-containing protein 0.0099 0.0305 0.0305
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.1066 0.3706 0.3706
Echinococcus multilocularis transcription factor btf3 0.0036 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-31 0.1066 0.3706 0.6143
Brugia malayi nuclear hormone receptor family member nhr-6 0.0503 0.1725 0.2858
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0044 0.0111 0.0111
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.047 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.1066 0.3706 0.3706
Echinococcus granulosus retinoic acid receptor rxr beta a 0.1066 0.3706 0.3706
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0599
Echinococcus multilocularis N chimaerin 0.0045 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.1066 0.3706 0.3706
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Onchocerca volvulus 0.0058 0.016 0.0431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.101 1
Onchocerca volvulus 0.0044 0.0111 0.0299
Toxoplasma gondii exonuclease III APE 0.0016 0.001 0.0676
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Trypanosoma brucei conserved protein 0.0044 0.0111 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Echinococcus multilocularis tyrosine protein kinase Srms 0.0058 0.016 0.016
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0563 0.1937 0.1937
Schistosoma mansoni tensin 0.0045 0.0115 0.0117
Brugia malayi SH2 domain containing protein 0.0058 0.016 0.0265
Brugia malayi cytokine inducible SH2-containing protein 5 0.0045 0.0115 0.019
Echinococcus granulosus tensin 0.0045 0.0115 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0081 0.0805
Echinococcus granulosus tyrosine protein kinase Srms 0.0058 0.016 0.016
Brugia malayi hypothetical protein 0.0058 0.016 0.0265
Entamoeba histolytica hypothetical protein 0.0044 0.0111 0.1098
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0045 0.0115 0.0115
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0599
Echinococcus granulosus growth factor receptor bound protein 2 0.009 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0029
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0503 0.1725 0.1725
Brugia malayi hypothetical protein 0.003 0.0061 0.01
Loa Loa (eye worm) variant SH3 domain-containing protein 0.009 0.0271 0.0271
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0001 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0503 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0563 0.1937 0.1937
Echinococcus granulosus tar DNA binding protein 0.0053 0.0141 0.0141
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0044 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0044 0.0111 0.0111
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0044 0.0111 0.1098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.1066 0.3706 0.6143
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0052 0.0138 0.2771
Brugia malayi hypothetical protein 0.0503 0.1725 0.2858
Brugia malayi SH3 domain containing protein 0.0044 0.0111 0.0184
Onchocerca volvulus Huntingtin homolog 0.0102 0.0314 0.0847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.1066 0.3706 0.3706
Schistosoma mansoni lamin 0.0045 0.0115 0.0117
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0045 0.0115 0.0117
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.1066 0.3706 0.3706
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0036 0.0081 0.0805
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.1066 0.3706 0.3766
Echinococcus multilocularis lamin 0.0045 0.0115 0.0115
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0044 0.0111 0.0111
Schistosoma mansoni tyrosine kinase 0.0102 0.0315 0.032
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0102 0.0315 0.0315
Schistosoma mansoni aldehyde dehydrogenase 0.0052 0.0138 0.014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0138 0.2771
Echinococcus multilocularis transfer RNA-Ala 0.0044 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0111 0.1098
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0599
Echinococcus granulosus expressed conserved protein 0.0045 0.0115 0.0115
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0045 0.0115 0.0115
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0081 0.7334
Brugia malayi STAT protein, DNA binding domain containing protein 0.0045 0.0115 0.019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.001 0.0923
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0045 0.0115 0.0115
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0041 0.0101 0.0168
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.016 0.016
Schistosoma mansoni lamin 0.0045 0.0115 0.0117
Echinococcus granulosus c src tyrosine kinase 0.0102 0.0315 0.0315
Entamoeba histolytica hypothetical protein 0.0044 0.0111 0.1098
Schistosoma mansoni nuclear receptor 0.0503 0.1725 0.1753
Loa Loa (eye worm) hypothetical protein 0.1066 0.3706 0.3706
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0045 0.0115 0.0117
Brugia malayi Variant SH3 domain containing protein 0.0045 0.0115 0.019
Brugia malayi photoreceptor-specific nuclear receptor 0.1066 0.3706 0.6143
Loa Loa (eye worm) thyroid receptor interactor 0.0044 0.0111 0.0111
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0044 0.0111 0.0111
Echinococcus multilocularis tensin 0.0045 0.0115 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0093 0.0094
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.001 0.0101
Loa Loa (eye worm) hypothetical protein 0.0041 0.0101 0.0101
Brugia malayi Variant SH3 domain containing protein 0.0044 0.0111 0.0184
Schistosoma mansoni GTPase activating protein 0.0045 0.0115 0.0117
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0044 0.0111 0.0111
Loa Loa (eye worm) transcription factor SMAD2 0.0099 0.0305 0.0305
Brugia malayi Nuclear hormone receptor-like 1 0.0563 0.1937 0.321
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2855 1 1
Schistosoma mansoni cpg binding protein 0.0029 0.0059 0.006
Echinococcus granulosus N chimaerin 0.0045 0.0115 0.0115
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.1066 0.3706 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.1066 0.3706 0.3706
Onchocerca volvulus Bile acid receptor homolog 0.1066 0.3706 1
Schistosoma mansoni hypothetical protein 0.0045 0.0115 0.0117
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-1 0.1066 0.3706 0.6143
Schistosoma mansoni intermediate filament proteins 0.0045 0.0115 0.0117
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0044 0.0111 0.0113
Echinococcus multilocularis Spectrin alpha actinin 0.0044 0.0111 0.0111
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.1066 0.3706 0.3706
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Echinococcus granulosus Nuclear hormone receptor HR96 0.0503 0.1725 0.1725
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0045 0.0115 0.0115
Echinococcus granulosus tyrosine protein kinase shark 0.0058 0.016 0.016
Brugia malayi Protein kinase domain containing protein 0.0058 0.016 0.0265
Loa Loa (eye worm) SH2 domain-containing protein 0.0045 0.0115 0.0115
Brugia malayi hypothetical protein 0.0503 0.1725 0.2858
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0052 0.0138 0.0138
Echinococcus granulosus tyrosine protein kinase Fyn 0.0102 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Onchocerca volvulus 0.0058 0.016 0.0431
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0028 0.0055 0.0056
Schistosoma mansoni tensin 0.0045 0.0115 0.0117
Schistosoma mansoni nuclear hormone receptor 0.0503 0.1725 0.1753
Loa Loa (eye worm) TK/ABL protein kinase 0.2855 1 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0102 0.0315 0.0315
Echinococcus granulosus transcription factor btf3 0.0036 0.0081 0.0081
Brugia malayi RhoGAP domain containing protein 0.0045 0.0115 0.019
Echinococcus granulosus tyrosine kinase 0.0058 0.016 0.016
Echinococcus multilocularis tyrosine protein kinase Blk 0.0058 0.016 0.016
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0045 0.0115 0.0115
Brugia malayi Nuclear hormone receptor-like 1 0.1066 0.3706 0.6143
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0044 0.0111 0.0113
Brugia malayi Peripheral plasma membrane protein CASK 0.0044 0.0111 0.0184
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0102 0.0315 0.0315
Brugia malayi protein-tyrosine kinase 0.0058 0.016 0.0265
Echinococcus granulosus tyrosine protein kinase Blk 0.0058 0.016 0.016
Echinococcus granulosus tyrosine protein kinase Fyn 0.0102 0.0315 0.0315
Echinococcus granulosus nuclear receptor 2DBD gamma 0.1066 0.3706 0.3706
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0044 0.0111 0.0113
Schistosoma mansoni transcription factor btf3 0.0036 0.0081 0.0083
Loa Loa (eye worm) DR-78 0.0503 0.1725 0.1725
Brugia malayi Variant SH3 domain containing protein 0.0044 0.0111 0.0184
Schistosoma mansoni ap endonuclease 0.0016 0.001 0.001
Brugia malayi nuclear receptor RXR 0.0503 0.1725 0.2858
Schistosoma mansoni thyroid hormone receptor 0.1066 0.3706 0.3766
Echinococcus multilocularis 0.0045 0.0115 0.0115
Echinococcus granulosus SH2 domain containing adapter protein F 0.0045 0.0115 0.0115
Echinococcus granulosus nuclear receptor nhr 48 0.0503 0.1725 0.1725
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.001 0.0017
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0044 0.0111 0.0299
Loa Loa (eye worm) hypothetical protein 0.009 0.0271 0.0271
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0081 0.7334
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0563 0.1937 0.1968
Brugia malayi Nuclear hormone receptor family member nhr-41 0.1066 0.3706 0.6143
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0563 0.1937 0.1937
Brugia malayi RNA binding protein 0.0053 0.0141 0.0233
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0503 0.1725 0.1725
Echinococcus multilocularis signal transduction protein lnk realted 0.0045 0.0115 0.0115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0093 0.0093
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0102 0.0315 0.0315
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0138 0.2771
Schistosoma mansoni tyrosine kinase 0.0102 0.0315 0.032
Schistosoma mansoni tyrosine kinase 0.281 0.984 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0111
Brugia malayi SH2 domain containing protein 0.0045 0.0115 0.019
Schistosoma mansoni run and tbc1 domain containing 0.0044 0.0111 0.0113
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.047 1
Schistosoma mansoni formin binding protein and related proteins 0.0044 0.0111 0.0113
Brugia malayi hypothetical protein 0.0563 0.1937 0.321
Schistosoma mansoni tensin 0.0045 0.0115 0.0117
Echinococcus multilocularis GPCR, family 2 0.0013 0.0001 0.0001
Brugia malayi nuclear receptor NHR-88 0.1066 0.3706 0.6143
Echinococcus granulosus fch and double sh3 domains protein 2 0.0044 0.0111 0.0111
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.1066 0.3706 0.3706
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.101 1
Brugia malayi Variant SH3 domain containing protein 0.0044 0.0111 0.0184
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.101 1
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0044 0.0111 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.1066 0.3706 0.6143
Loa Loa (eye worm) hypothetical protein 0.1066 0.3706 0.3706
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0315 0.0315
Echinococcus multilocularis tyrosine protein kinase Abl 0.1172 0.4078 0.4078
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.1066 0.3706 0.3706
Echinococcus granulosus tyrosine protein kinase Fyn 0.0102 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.1066 0.3706 0.3706
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0044 0.0111 0.0111
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0503 0.1725 0.4653
Echinococcus granulosus endophilin A3 0.0044 0.0111 0.0111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.101 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.1066 0.3706 0.3706
Echinococcus multilocularis lamin dm0 0.0045 0.0115 0.0115
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0081 0.0805
Loa Loa (eye worm) protein-tyrosine kinase 0.0044 0.0111 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.1066 0.3706 0.6143
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0045 0.0115 0.031
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0053 0.0141 0.0141
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0175 0.0178
Echinococcus multilocularis SH2 motif 0.0045 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0111 0.1098
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Brugia malayi nuclear receptor NHR-67 0.0503 0.1725 0.2858
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.0314
Brugia malayi Nuclear hormone receptor-like 1 0.0563 0.1937 0.321
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.101 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.1066 0.3706 0.3706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.1066 0.3706 0.3706
Echinococcus granulosus signal transduction protein lnk realted 0.0045 0.0115 0.0115
Echinococcus multilocularis tyrosine protein kinase shark 0.0058 0.016 0.016
Loa Loa (eye worm) nuclear receptor NHR-67 0.0503 0.1725 0.1725
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0563 0.1937 0.1968
Onchocerca volvulus 0.0058 0.016 0.0431
Loa Loa (eye worm) hypothetical protein 0.0563 0.1937 0.1937
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Echinococcus granulosus tyrosine kinase 0.0058 0.016 0.016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0001 0.0001
Echinococcus multilocularis growth factor receptor bound protein 2 0.009 0.0271 0.0271
Schistosoma mansoni SH2A 0.0045 0.0115 0.0117
Echinococcus multilocularis intersectin 2 0.0044 0.0111 0.0111
Onchocerca volvulus 0.0045 0.0115 0.031
Echinococcus granulosus suppressor of cytokine signaling 6 0.0045 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0013 0.0001 0.0001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0503 0.1725 0.4653
Onchocerca volvulus 0.0045 0.0115 0.031
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0045 0.0115 0.0115
Schistosoma mansoni tyrosine kinase 0.0058 0.016 0.0162
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0022 0.0032 0.0032
Onchocerca volvulus 0.0044 0.0111 0.0299
Brugia malayi Guanylate kinase family protein 0.0044 0.0111 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-14 0.1066 0.3706 0.6143
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Entamoeba histolytica hypothetical protein 0.0044 0.0111 0.1098
Schistosoma mansoni adapter molecule crk 0.009 0.0271 0.0275
Echinococcus multilocularis nuclear receptor nhr 48 0.0503 0.1725 0.1725
Brugia malayi Steroid receptor seven-up type 2 0.1066 0.3706 0.6143
Brugia malayi Protein kinase domain containing protein 0.0058 0.016 0.0265
Brugia malayi Variant SH3 domain containing protein 0.009 0.0271 0.0448
Brugia malayi latrophilin 2 splice variant baaae 0.0028 0.0055 0.0091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.101 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0563 0.1937 0.1937
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0041 0.0101 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.1066 0.3706 0.3706
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0081 0.0805
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0102 0.0315 0.032
Echinococcus granulosus NCK adaptor protein 0.009 0.0271 0.0271
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0115 0.0115
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.001 0.001
Brugia malayi Tyrosine-protein kinase abl-1 0.1172 0.4078 0.6759
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0044 0.0111 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0141 0.0143
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0052 0.0138 0.0138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.101 1
Brugia malayi nuclear hormone receptor 0.0503 0.1725 0.2858
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.1066 0.3706 0.3766
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.009 0.0271 0.0275
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Schistosoma mansoni nuclear receptor 0.0503 0.1725 0.1753
Entamoeba histolytica hypothetical protein 0.0044 0.0111 0.1098
Brugia malayi steroid hormone receptor 0.1066 0.3706 0.6143
Schistosoma mansoni Dab2-interacting protein-like 0.0044 0.0111 0.0113
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0115 0.0115
Brugia malayi Variant SH3 domain containing protein 0.0044 0.0111 0.0184
Echinococcus multilocularis tar DNA binding protein 0.0053 0.0141 0.0141
Brugia malayi hypothetical protein 0.0563 0.1937 0.321
Entamoeba histolytica SH2 domain containing protein 0.0045 0.0115 0.1137
Brugia malayi Variant SH3 domain containing protein 0.009 0.0271 0.0448
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0032
Schistosoma mansoni ap endonuclease 0.0016 0.001 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.101 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0112 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0141 0.0143
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0081 0.0081
Onchocerca volvulus 0.0503 0.1725 0.4653
Echinococcus granulosus SHC transforming protein 3 0.0045 0.0115 0.0115
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.001 0.0743
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.016 0.016
Schistosoma mansoni thyroid hormone receptor 0.1066 0.3706 0.3766
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.016 0.016
Onchocerca volvulus 0.0503 0.1725 0.4653
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0138 0.2771
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.016 0.016
Schistosoma mansoni nuclear receptor nhr-48 0.0503 0.1725 0.1753
Brugia malayi Tensin 0.0045 0.0115 0.019
Brugia malayi SH2 domain containing protein 0.0045 0.0115 0.019
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.016 0.016
Echinococcus granulosus hypothetical protein 0.0045 0.0115 0.0115
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0045 0.0115 0.0115
Loa Loa (eye worm) SH2 domain-containing protein 0.0045 0.0115 0.0115
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0022 0.0032 0.0032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0001 0.0001
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0044 0.0111 0.0111
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0503 0.1725 0.2858
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Schistosoma mansoni nck2/grb4 0.009 0.0271 0.0275
Entamoeba histolytica protein kinase, putative 0.0045 0.0115 0.1137
Leishmania major basic transcription factor 3a, putative 0.0036 0.0081 0.5905
Brugia malayi Variant SH3 domain containing protein 0.0045 0.0115 0.019
Loa Loa (eye worm) p53BP2 0.0044 0.0111 0.0111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.101 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.1066 0.3706 0.6143
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0102 0.0315 0.0315
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1368 0.4767 0.4767
Echinococcus granulosus Nuclear hormone receptor HR96 0.0503 0.1725 0.1725
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0111 0.1098
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.001 0.0101
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.1066 0.3706 0.3706
Onchocerca volvulus 0.0058 0.016 0.0431
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0001 0.0001
Loa Loa (eye worm) RNA binding protein 0.0053 0.0141 0.0141
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0081 0.5368
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0141 0.0143
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0093 0.0093
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0024 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.003 0.0061 0.0061
Brugia malayi SH2 domain containing protein 0.0045 0.0115 0.019
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0115 0.0115
Onchocerca volvulus Protein ultraspiracle homolog 0.1066 0.3706 1
Brugia malayi beta-NAC-like protein 0.0036 0.0081 0.0135
Echinococcus multilocularis SH2 motif 0.0045 0.0115 0.0115
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0503 0.1725 0.1725
Echinococcus multilocularis nostrin 0.0044 0.0111 0.0111
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0315 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-25 0.1066 0.3706 0.6143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.1066 0.3706 0.3706
Echinococcus multilocularis cpg binding protein 0.0031 0.0065 0.0065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0093 0.0093
Schistosoma mansoni growth factor receptor-bound protein 0.009 0.0271 0.0275
Echinococcus multilocularis SHC transforming protein 3 0.0045 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0156 0.0158
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.047 1
Brugia malayi Myosin tail family protein 0.0044 0.0111 0.0184
Onchocerca volvulus 0.0045 0.0115 0.0311
Loa Loa (eye worm) hypothetical protein 0.1066 0.3706 0.3706
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.001 0.1259
Echinococcus multilocularis c src tyrosine kinase 0.0102 0.0315 0.0315
Echinococcus granulosus tyrosine protein kinase Lyn 0.0102 0.0315 0.0315
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0503 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0503 0.1725 0.1753
Echinococcus granulosus lamin 0.0045 0.0115 0.0115
Entamoeba histolytica hypothetical protein 0.003 0.0061 0.0599
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.001 0.0923
Schistosoma mansoni suppressor of cytokine signaling 0.0045 0.0115 0.0117
Loa Loa (eye worm) guanylate kinase 0.0044 0.0111 0.0111
Brugia malayi Protein kinase domain containing protein 0.0058 0.016 0.0265
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0111
Brugia malayi ecdysteroid receptor 0.1066 0.3706 0.6143
Brugia malayi protein-tyrosine kinase 0.0044 0.0111 0.0184
Brugia malayi Fes/CIP4 homology domain containing protein 0.0044 0.0111 0.0184
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0039 0.0093 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.016 0.016
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.016 0.016
Schistosoma mansoni shc transforming protein 0.0045 0.0115 0.0117
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.1066 0.3706 0.3706
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.016 0.016
Loa Loa (eye worm) steroid hormone receptor 0.1066 0.3706 0.3706
Brugia malayi ecdysone receptor 0.0503 0.1725 0.2858
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.1066 0.3706 0.3706
Brugia malayi TAR-binding protein 0.0053 0.0141 0.0233
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0151 1
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0044 0.0111 0.0113
Brugia malayi SH2 domain containing protein 0.0045 0.0115 0.019
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0111 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0045 0.0115 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.101 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.101 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.1082 0.3762 0.3762
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0093 0.0094
Loa Loa (eye worm) hypothetical protein 0.0563 0.1937 0.1937
Echinococcus granulosus thyroid hormone receptor alpha 0.0503 0.1725 0.1725
Echinococcus multilocularis endophilin A3 0.0044 0.0111 0.0111
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0115 0.0115
Echinococcus granulosus tyrosine protein kinase Src64B 0.0102 0.0315 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0111 0.1098
Loa Loa (eye worm) hypothetical protein 0.1066 0.3706 0.3706
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0058 0.016 0.1581
Schistosoma mansoni hypothetical protein 0.0045 0.0115 0.0117
Brugia malayi SH2 domain containing protein 0.0045 0.0115 0.019
Loa Loa (eye worm) sex muscle abnormal protein 5 0.009 0.0271 0.0271
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0045 0.0115 0.031
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.101 1
Onchocerca volvulus 0.0058 0.016 0.0431
Brugia malayi RNA recognition motif domain containing protein 0.0053 0.0141 0.0233
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Onchocerca volvulus 0.0044 0.0111 0.0299
Loa Loa (eye worm) hypothetical protein 0.1066 0.3706 0.3706
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Echinococcus granulosus GPCR family 2 0.0013 0.0001 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0061 0.0061
Loa Loa (eye worm) SH2 domain-containing protein 0.0045 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0044 0.0111 0.0113
Echinococcus granulosus epidermal growth factor receptor kinase 0.0044 0.0111 0.0111
Brugia malayi Intermediate filament tail domain containing protein 0.0045 0.0115 0.0191
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.001 0.0101
Onchocerca volvulus 0.0045 0.0115 0.031
Echinococcus granulosus Spectrin alpha actinin 0.0044 0.0111 0.0111
Schistosoma mansoni steroid hormone receptor ad4bp 0.1066 0.3706 0.3766
Echinococcus granulosus SH2 domain containing protein 7 0.0045 0.0115 0.0115
Brugia malayi Variant SH3 domain containing protein 0.0044 0.0111 0.0184
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0055
Echinococcus multilocularis NCK adaptor protein 0.009 0.0271 0.0271
Echinococcus multilocularis ecdysone induced protein 78C 0.1066 0.3706 0.3706
Entamoeba histolytica hypothetical protein 0.0044 0.0111 0.1098
Brugia malayi nuclear hormone receptor family member odr-7 0.0503 0.1725 0.2858
Brugia malayi MH2 domain containing protein 0.0099 0.0305 0.0505
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0081 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0102 0.0315 0.0315
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0045 0.0115 0.0117
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0045 0.0115 0.0115
Loa Loa (eye worm) TK protein kinase 0.0058 0.016 0.016
Schistosoma mansoni tyrosine kinase 0.0102 0.0315 0.032
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.1066 0.3706 0.3706
Echinococcus granulosus SH2 motif 0.0045 0.0115 0.0115
Schistosoma mansoni eps8-related protein 0.0044 0.0111 0.0113
Echinococcus granulosus intersectin 2 0.0044 0.0111 0.0111
Echinococcus multilocularis musashi 0.0045 0.0115 0.0115
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.001 0.0923
Brugia malayi Nuclear hormone receptor E75 0.0503 0.1725 0.2858
Schistosoma mansoni cpg binding protein 0.0031 0.0065 0.0066
Trichomonas vaginalis p67phox protein, putative 0.0044 0.0111 0.1098
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0081 0.7334
Toxoplasma gondii aldehyde dehydrogenase 0.0052 0.0138 0.9091
Schistosoma mansoni growth factor receptor-bound protein 0.009 0.0271 0.0275
Echinococcus granulosus nostrin 0.0044 0.0111 0.0111
Schistosoma mansoni C-fyn 0.0044 0.0111 0.0113
Entamoeba histolytica hypothetical protein 0.0044 0.0111 0.1098
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0503 0.1725 0.1725
Schistosoma mansoni Tr4/Tr2 (homologue) 0.1066 0.3706 0.3766
Schistosoma mansoni tensin-related 0.0045 0.0115 0.0117
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0058 0.016 0.016
Echinococcus granulosus cpg binding protein 0.0031 0.0065 0.0065
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0102 0.0315 0.0315
Entamoeba histolytica unconventional myosin IB 0.0044 0.0111 0.1098
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0111
Onchocerca volvulus 0.0045 0.0115 0.031
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0111 1
Brugia malayi SRC-1 0.0102 0.0315 0.0523
Echinococcus granulosus expressed protein 0.0044 0.0111 0.0111
Echinococcus granulosus src region 0.0044 0.0111 0.0111
Echinococcus multilocularis tyrosine kinase 0.0058 0.016 0.016
Schistosoma mansoni coup transcription factor 0.1066 0.3706 0.3766
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0045 0.0115 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0093 0.0094
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0044 0.0111 0.0111
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0045 0.0115 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0053 0.0141 0.0141
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0115 0.019
Loa Loa (eye worm) hypothetical protein 0.0563 0.1937 0.1937
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0058 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Brugia malayi Nuclear hormone receptor E75 0.0503 0.1725 0.2858
Schistosoma mansoni nuclear hormone receptor 0.1066 0.3706 0.3766
Schistosoma mansoni retinoid-x-receptor (RXR) 0.1066 0.3706 0.3766
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Brugia malayi orphan nuclear receptor NR2E1 0.0503 0.1725 0.2858
Brugia malayi Nuclear hormone receptor family member nhr-40 0.1066 0.3706 0.6143
Brugia malayi SH2 domain containing protein 0.0045 0.0115 0.019
Brugia malayi SH2 domain containing protein 0.0045 0.0115 0.019
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0141 0.0143
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0102 0.0315 0.0315
Echinococcus multilocularis geminin 0.0286 0.0961 0.0961
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.0314
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0503 0.1725 0.1725
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0045 0.0115 0.0115
Loa Loa (eye worm) SRC-1 0.0102 0.0315 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-3 0.1066 0.3706 0.6143
Schistosoma mansoni sorbin 0.0044 0.0111 0.0113
Entamoeba histolytica BAR/SH3 domain containing protein 0.0044 0.0111 0.1098
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0016 0.001 0.0101
Schistosoma mansoni hypothetical protein 0.0013 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.1066 0.3706 0.6143
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0102 0.0315 0.0315
Echinococcus granulosus suppressor of cytokine signaling 7 0.0045 0.0115 0.0115
Echinococcus multilocularis expressed protein 0.0044 0.0111 0.0111
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0058 0.016 0.016
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0102 0.0315 0.0315
Brugia malayi conserved hypotetical protein 0.0503 0.1725 0.2858
Loa Loa (eye worm) hypothetical protein 0.0058 0.016 0.016
Onchocerca volvulus 0.0045 0.0115 0.031
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Onchocerca volvulus 0.0045 0.0115 0.0311
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0016 0.001 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0052 0.0138 0.014
Onchocerca volvulus 0.0044 0.0111 0.0299
Entamoeba histolytica hypothetical protein 0.0044 0.0111 0.1098
Schistosoma mansoni hypothetical protein 0.0013 0.0001 0.0001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0045 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0503 0.1725 0.1725
Brugia malayi nuclear receptor RXR 0.0563 0.1937 0.321
Onchocerca volvulus 0.0058 0.016 0.0431
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0503 0.1725 0.1725
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0111 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0503 0.1725 0.1753
Echinococcus granulosus tyrosine protein kinase Src42A 0.0102 0.0315 0.0315
Schistosoma mansoni tyrosine kinase 0.0102 0.0315 0.032
Schistosoma mansoni dreadlocks/dock 0.0044 0.0111 0.0113
Entamoeba histolytica BAR/SH3 domain containing protein 0.0044 0.0111 0.1098
Brugia malayi Protein kinase domain containing protein 0.0058 0.016 0.0265
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0045 0.0115 0.0117
Schistosoma mansoni hypothetical protein 0.0286 0.0961 0.0976
Schistosoma mansoni dynamin-associated protein 0.0044 0.0111 0.0113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.1066 0.3706 0.3766
Schistosoma mansoni tensin-related 0.0045 0.0115 0.0117
Brugia malayi Protein kinase domain containing protein 0.0058 0.016 0.0265
Schistosoma mansoni RAR-like nuclear receptor 0.1066 0.3706 0.3766
Schistosoma mansoni zinc finger protein 0.0503 0.1725 0.1753
Schistosoma mansoni sorting nexin 0.0044 0.0111 0.0113
Schistosoma mansoni tyrosine kinase 0.0058 0.016 0.0162
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0111
Brugia malayi nuclear receptor NHR-88 0.0503 0.1725 0.2858
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Onchocerca volvulus 0.0044 0.0111 0.0299
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.001 0.001
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0044 0.0111 0.0111
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0045 0.0115 0.0115
Brugia malayi Calcitonin receptor-like protein seb-1 0.0041 0.0101 0.0168
Brugia malayi Tyrosine-protein kinase abl-1 0.1728 0.6033 1
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0001 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.1066 0.3706 0.3706
Brugia malayi Variant SH3 domain containing protein 0.0044 0.0111 0.0184
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0052 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.1066 0.3706 0.3706
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0045 0.0115 0.1137
Brugia malayi Spectrin alpha chain 0.0044 0.0111 0.0184
Echinococcus multilocularis SH2 domain containing protein 7 0.0045 0.0115 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0141 0.0143
Schistosoma mansoni hypothetical protein 0.0286 0.0961 0.0976
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0111 0.1098
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.0111 0.1098
Onchocerca volvulus 0.0045 0.0115 0.031
Brugia malayi cytoplasmic intermediate filament protein 0.0024 0.0041 0.0068
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.001 0.001
Echinococcus granulosus lamin dm0 0.0045 0.0115 0.0115
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.1066 0.3706 0.3766
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0111
Echinococcus multilocularis tensin 0.0045 0.0115 0.0115
Brugia malayi SH2 domain containing protein 0.0058 0.016 0.0265
Onchocerca volvulus 0.1066 0.3706 1
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0044 0.0111 0.0111
Echinococcus granulosus ecdysone induced protein 78C 0.1066 0.3706 0.3706
Echinococcus multilocularis SH2 motif 0.0045 0.0115 0.0115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0093 0.0093
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0044 0.0111 0.0111
Schistosoma mansoni retinoic acid receptor RXR 0.1066 0.3706 0.3766
Schistosoma mansoni apoptosis stimulating of P53 0.0044 0.0111 0.0113
Leishmania major hypothetical protein, conserved 0.0044 0.0111 0.8051
Schistosoma mansoni cell polarity protein 0.0044 0.0111 0.0113
Schistosoma mansoni cpg binding protein 0.0031 0.0065 0.0066
Brugia malayi nuclear hormone receptor 0.1066 0.3706 0.6143
Loa Loa (eye worm) hypothetical protein 0.0045 0.0115 0.0115
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0013 0.0001 0.0001
Brugia malayi hypothetical protein 0.0102 0.0314 0.052
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.016 0.016
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0115 0.0115
Brugia malayi tailless protein 0.0503 0.1725 0.2858
Brugia malayi Src substrate cortactin 0.0044 0.0111 0.0184
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0039 0.0093 0.0154
Echinococcus granulosus geminin 0.0286 0.0961 0.0961
Schistosoma mansoni suppressor of cytokine signaling 0.0045 0.0115 0.0117
Onchocerca volvulus 0.0029 0.0059 0.0159

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3 nM 50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme. ChEMBL. 12372522
IC50 (binding) = 3 nM Inhibition of Lck (unknown origin) ChEMBL. 18271520
IC50 (binding) = 3 nM 50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme. ChEMBL. 12372522
IC50 (binding) = 3 nM Inhibition of Lck (unknown origin) ChEMBL. 18271520
IC50 (functional) = 380 nM 50% inhibition of T-cell proliferation induced by anti-CD3/anti-CD28 co-stimulation in human peripheral blood leukocytes (PBLs). ChEMBL. 12372522
IC50 (functional) = 380 nM Inhibition of T cell proliferation (unknown origin) ChEMBL. 18271520

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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