Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Mus musculus | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0032 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0032 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0032 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0032 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0032 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0032 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0029 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.002 | 0.2407 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0032 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.002 | 0.2407 | 0.2407 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0032 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0016 | 0.0151 | 0.0151 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0032 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0016 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0029 | 0.7743 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0032 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD (binding) | = 12.1 uM | Induction of quinone reductase-1 activity in mouse Hepa-1c1c7 cells assessed as concentration required to double induction activity by MTT assay | ChEMBL. | 23994869 |
FC (binding) | = 0.5 | Agonist activity at human RXR-alpha transfected in african green monkey COS-1 cells at 50 uM by dual-luciferase reporter gene assay relative to control | ChEMBL. | 23994869 |
IC50 (binding) | = 2.6 uM | Inhibition of aromatase (unknown origin) using dibenzylfluorscein as substrate incubated with NADP+ for 10 mins prior to substrate addition measured after 30 mins by fluorescence assay | ChEMBL. | 23994869 |
IC50 (binding) | = 6.4 uM | Inhibition of iNOS-mediated NO production in mouse RAW264.7 cells by Griess assay | ChEMBL. | 23994869 |
IC50 (ADMET) | = 11.6 uM | Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 15 mins by SRB assay | ChEMBL. | 23994869 |
IC50 (ADMET) | = 46.5 uM | Cytotoxicity against human HEK293 cells assessed as reduction in cell survival | ChEMBL. | 23994869 |
Inhibition (binding) | = 97.7 % | Inhibition of iNOS-mediated NO production in mouse RAW264.7 cells at 50 uM by Griess assay | ChEMBL. | 23994869 |
Inhibition (binding) | = 98.6 % | Inhibition of aromatase (unknown origin) using dibenzylfluorscein as substrate incubated with NADP+ for 10 mins prior to substrate addition at 50 uM measured after 30 mins by fluorescence assay | ChEMBL. | 23994869 |
Survival (ADMET) | = 48.2 % | Cytotoxicity against mouse RAW264.7 cells assessed as cell survival at 50 uM after 15 mins by SRB assay | ChEMBL. | 23994869 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 23994869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.