Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1341 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0552 | 0.3066 | 0.3066 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0552 | 0.3066 | 0.3066 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0552 | 0.3066 | 0.3066 |
Echinococcus multilocularis | protein dispatched 1 | 0.0552 | 0.3066 | 0.3066 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0552 | 0.3066 | 0.3066 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1341 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1341 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0552 | 0.3066 | 0.3066 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1341 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1341 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1341 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1341 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0552 | 0.3066 | 0.3066 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1341 | 1 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0552 | 0.3066 | 0.3066 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0629 | 0.3743 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0552 | 0.3066 | 0.3066 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0629 | 0.3743 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0629 | 0.3743 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1341 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0629 | 0.3743 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Cytotoxicity against human SKOV3 cells after 3 days by MTT assay | ChEMBL. | 24095745 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.