Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0171 | 0.8567 | 0.8567 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0087 | 0.3698 | 0.407 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1539 | 0.1729 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3413 | 0.3934 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.2677 | 0.2677 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0198 | 0.0198 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.2916 | 0.2916 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0171 | 0.8567 | 0.8567 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0171 | 0.8567 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0171 | 0.8567 | 0.8567 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0171 | 0.8567 | 0.8567 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.2677 | 0.2677 |
Echinococcus multilocularis | geminin | 0.0196 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0171 | 0.8567 | 0.8567 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.1091 | 0.1091 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0171 | 0.8567 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0198 | 0.0198 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.1249 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1254 | 0.1393 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.1091 | 0.1091 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0071 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1412 | 0.1579 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 60 % | Cytotoxicity against human Raji cells assessed as cell viability at 1000 mol ratio/TPA after 48 hrs by trypan blue staining method | ChEMBL. | 24013411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.