TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.085 | Formula: C29H38ClN3O
H donors: 2 H acceptors: 1 LogP: 8.72 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCc1c([nH]c2c1cc(Cl)cc2)C(=O)NCCc1ccc(cc1)N1CCCCC1
InChi: 1S/C29H38ClN3O/c1-2-3-4-5-7-10-25-26-21-23(30)13-16-27(26)32-28(25)29(34)31-18-17-22-11-14-24(15-12-22)33-19-8-6-9-20-33/h11-16,21,32H,2-10,17-20H2,1H3,(H,31,34)
InChiKey: CXZRBWVJBXMSMS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0064	0.0064
Plasmodium vivax	vivapain-2	0.0026	0.0445	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1176	0.9388
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0014	0.0159	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.3188	0.3188
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0159	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0075
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Brugia malayi	cathepsin B-like cysteine proteinase	0.0139	0.3188	0.782
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.001	0.0074	0.0075
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.1246	0.1246
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Schistosoma mansoni	hypothetical protein	0.0419	1	1
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0034	0.0643	0.0643
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0445	0.1219
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Trypanosoma brucei	oligopeptidase b	0.0014	0.0159	0.0799
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0026	0.0445	0.1219
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0445	1
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0175	0.4065	1
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0014	0.0159	0.0303
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.005	0.103	0.3093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.3188	0.3188
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0445	0.0998
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.005	0.1029	0.1029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Leishmania major	cysteine peptidase A (CPA)	0.0026	0.0445	0.2624
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Trypanosoma cruzi	oligopeptidase b	0.0014	0.0159	0.0303
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.005	0.103	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0445	0.1219
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0159	0.0303
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0046	0.0937	0.0937
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.1246	0.1246
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.0445	0.1219
Trypanosoma brucei	prolyl endopeptidase	0.0014	0.0159	0.0799
Brugia malayi	metabotropic glutamate receptor type 2	0.002	0.03	0.0645
Loa Loa (eye worm)	glutamate receptor	0.004	0.0802	0.1887
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Brugia malayi	Metabotropic glutamate receptor precursor.	0.004	0.0802	0.1893
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0014	0.0159	0.0159
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0159	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0159	0.0286
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0014	0.0159	0.0303
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0014	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.001	0.0074	0.0075
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0064	0.0058
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1246	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0445	0.0445
Toxoplasma gondii	cathepsin CPL	0.0026	0.0445	0.3214
Echinococcus multilocularis	cathepsin L	0.001	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Brugia malayi	Receptor family ligand binding region containing protein	0.001	0.0074	0.0082
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0059	0.1249	1
Loa Loa (eye worm)	cathepsin B	0.005	0.103	0.2453
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.001	0.0064	0.0064
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0445	0.0445
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0445	1
Schistosoma mansoni	metabotropic glutamate receptor	0.002	0.03	0.03
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0064	0.0058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0445	0.0998
Toxoplasma gondii	hypothetical protein	0.0014	0.0159	0.0799
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1338	0.1338
Brugia malayi	prolyl oligopeptidase family protein	0.0059	0.1249	0.3002
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0014	0.0159	0.098
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1246	0.1246
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.001	0.0064	0.0058
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.1246	0.9979
Schistosoma mansoni	cpg binding protein	0.0029	0.0537	0.0537
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0445	0.0445
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0445	0.0445
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0014	0.0159	0.0159
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0059	0.1249	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3188	0.7819
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0014	0.0159	0.098
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0445	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0913	0.2161
Brugia malayi	cathepsin L-like precursor	0.0026	0.0445	0.1004
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0139	0.3188	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Echinococcus granulosus	cathepsin l1	0.0026	0.0445	0.0445
Echinococcus multilocularis	cysteine protease	0.0026	0.0445	0.0445
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0175	0.4065	0.4065
Echinococcus multilocularis	cysteine protease	0.0026	0.0445	0.0445
Onchocerca volvulus		0.0026	0.0445	0.0952
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.001	0.0064	0.0051
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0445	0.0998
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0014	0.0159	0.2488
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0064	0.0058
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.001	0.0064	0.0051
Giardia lamblia	Cathepsin B precursor	0.005	0.103	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Loa Loa (eye worm)	fibroinase	0.0026	0.0445	0.0998
Brugia malayi	prolyl oligopeptidase family protein	0.0175	0.4065	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.1246	0.9978
Echinococcus multilocularis	cpg binding protein	0.0031	0.0578	0.0578
Loa Loa (eye worm)	prolyl oligopeptidase	0.0014	0.0159	0.0286
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0445	0.1004
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0445	0.1219
Entamoeba histolytica	hypothetical protein, conserved	0.0014	0.0159	0.2488
Schistosoma mansoni	cathepsin B (C01 family)	0.001	0.0064	0.0064
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.005	0.103	0.7994
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0014	0.0159	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0445	0.0998
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1246	1
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0034	0.0643	0.0643
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0014	0.0159	0.0799
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.3188	0.3188
Loa Loa (eye worm)	hypothetical protein	0.005	0.1029	0.245
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0159	0.2488
Loa Loa (eye worm)	prolyl oligopeptidase	0.0175	0.4065	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Giardia lamblia	Cathepsin B precursor	0.005	0.103	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0159	0.0286
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0064	0.0064
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0445	0.1219
Toxoplasma gondii	prolyl endopeptidase	0.0014	0.0159	0.0799
Brugia malayi	fibroinase precursor	0.001	0.0064	0.0058
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0175	0.4065	0.4065
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0059	0.1249	0.3793
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0037	0.071	0.1664
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0014	0.0159	0.0799
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0445	0.0445
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0064	0.0058
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0537	0.1227
Onchocerca volvulus		0.0026	0.0445	0.0952
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0445	1
Echinococcus granulosus	cathepsin b	0.0139	0.3188	0.3188
Schistosoma mansoni	cathepsin S (C01 family)	0.001	0.0064	0.0064
Echinococcus multilocularis	cathepsin b	0.0139	0.3188	0.3188
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Brugia malayi	cathepsin Z-like cysteine proteinase	0.001	0.0064	0.0058
Echinococcus multilocularis	cathepsin L	0.001	0.0064	0.0064
Schistosoma mansoni	cpg binding protein	0.0031	0.0578	0.0578
Loa Loa (eye worm)	ctsf protein	0.0026	0.0445	0.0998
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0064	0.0064
Loa Loa (eye worm)	glutamate receptor	0.0016	0.0208	0.0409
Loa Loa (eye worm)	cysteine protease	0.0026	0.0445	0.0998
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0445	0.0952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0445	1
Brugia malayi	hypothetical protein	0.0045	0.0913	0.2167
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0445	0.0998
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0175	0.4065	0.4065
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.001	0.0064	0.0064
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0014	0.0159	0.2488
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Onchocerca volvulus		0.0026	0.0445	0.0952
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Onchocerca volvulus		0.0026	0.0445	0.0952
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	cysteine peptidase C (CPC)	0.005	0.103	0.8154
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0014	0.0159	0.0799
Onchocerca volvulus		0.0026	0.0445	0.0952
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0014	0.0159	0.098
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0445	0.0445
Echinococcus granulosus	cathepsin L cysteine protease	0.001	0.0064	0.0064
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0445	0.0952
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0014	0.0159	0.0159
Brugia malayi	prolyl oligopeptidase family protein	0.0014	0.0159	0.0293
Echinococcus granulosus	cpg binding protein	0.0031	0.0578	0.0578
Brugia malayi	cathepsin F-like cysteine proteinase	0.001	0.0064	0.0058
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0059	0.1249	0.1249
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0064	0.0064
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0445	0.0952
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0059	0.1249	0.3793
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0445	0.0998
Echinococcus granulosus	cathepsin L	0.001	0.0064	0.0064
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0059	0.1249	1
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0445	1
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0014	0.0159	0.2488
Brugia malayi	cathepsin L-like cysteine proteinase	0.001	0.0064	0.0058
Schistosoma mansoni	cpg binding protein	0.0031	0.0578	0.0578
Giardia lamblia	Cathepsin B precursor	0.005	0.103	1
Plasmodium falciparum	peptidase, putative	0.0014	0.0159	0.2488
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Echinococcus granulosus	cathepsin l1	0.0026	0.0445	0.0445
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.103	0.103
Echinococcus granulosus	cysteine protease	0.001	0.0064	0.0064
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0026	0.0445	0.1004
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0445	0.0445
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1246	0.1246
Echinococcus multilocularis	dnaJ subfamily B	0.0419	1	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0059	0.1249	0.1249
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0014	0.0159	0.2488
Echinococcus granulosus	cathepsin L	0.001	0.0064	0.0064
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0064	0.0064
Brugia malayi	prolyl oligopeptidase family protein	0.0014	0.0159	0.0293
Onchocerca volvulus		0.0029	0.0537	0.1182
Onchocerca volvulus		0.0026	0.0445	0.0952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0445	0.3941
Echinococcus granulosus	metabotropic glutamate receptor 5	0.005	0.1029	0.1029
Echinococcus granulosus	acylamino acid releasing enzyme	0.0014	0.0159	0.0159
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0014	0.0159	0.098
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0139	0.3188	0.3188
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Trypanosoma cruzi	prolyl endopeptidase	0.0014	0.0159	0.0303
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0064	0.0058
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0159	0.098
Echinococcus granulosus	prolyl endopeptidase	0.0014	0.0159	0.0159
Echinococcus granulosus	cathepsin b	0.0139	0.3188	0.3188
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.001	0.0064	0.0064
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.001	0.0064	0.0064
Schistosoma mansoni	metabotropic glutamate receptor	0.0034	0.0643	0.0643
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0537	0.1233
Brugia malayi	prolyl oligopeptidase family protein	0.0014	0.0159	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0445	0.3941
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0014	0.0159	0.0237
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0445	0.0445
Echinococcus multilocularis	cathepsin b	0.0139	0.3188	0.3188
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0445	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.001	0.0064	0.0051
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0445	0.0445
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1246	1
Plasmodium vivax	vivapain-2	0.0026	0.0445	1
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0014	0.0159	0.2488
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0059	0.1249	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.1246	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Toxoplasma gondii	cathepsin B	0.005	0.103	0.8154
Onchocerca volvulus		0.0026	0.0445	0.0952
Brugia malayi	cathepsin L precursor	0.001	0.0064	0.0058
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma cruzi	oligopeptidase b	0.0014	0.0159	0.0303
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0059	0.1249	0.1249
Onchocerca volvulus		0.0026	0.0445	0.0952
Brugia malayi	cathepsin Z-like cysteine proteinase	0.001	0.0064	0.0058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0014	0.0159	0.0159
Echinococcus multilocularis	prolyl endopeptidase	0.0014	0.0159	0.0159
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Schistosoma mansoni	cathepsin C	0.001	0.0064	0.0064

Activities

Activity type	Activity value	Assay description	Source	Reference
Kb (binding)	= 651.2 nM	Positive allosteric modulation of CB1 receptor (unknown origin) expressed in HEK293 cell membranes assessed as stimulation of [3H]CP55,940 binding after 60 mins by liquid scintillation counting analysis	ChEMBL.	24053617

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2431220

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1786871