Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.254 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.254 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.254 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0313 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.0313 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0135 | 0.7773 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.254 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0313 | 0.1234 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0313 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.254 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.254 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0.0313 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.254 | 1 |
Leishmania major | trypanothione reductase | 0.0053 | 0.254 | 1 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.0313 | 0.5 |
Brugia malayi | glutathione reductase | 0.0053 | 0.254 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.254 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0135 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0122 | 0.6906 | 0.8837 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0.0313 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.254 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.0313 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.254 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.254 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0313 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0122 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0122 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0122 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0122 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0135 | 0.7773 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0135 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0122 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.254 | 0.2985 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 100 ug ml-1 | Antimicrobial activity against Candida albicans MTCC 183 after 12 hrs by well diffusion method | ChEMBL. | 23994870 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.