Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 59 uM | Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method | ChEMBL. | 23909910 |
IC50 (binding) | = 95 uM | Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method | ChEMBL. | 23909910 |
Inhibition (binding) | < 30 % | Negative allosteric modulation of recombinant rat GluN2B receptor expressed in Xenopus laevis oocytes at 100 uM by two-electrode voltage clamp method | ChEMBL. | 23909910 |
Inhibition (binding) | < 30 % | Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes at 100 uM by two-electrode voltage clamp method | ChEMBL. | 23909910 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.