Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.6906 | 0.8837 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.7773 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0059 | 0.3472 | 0.3261 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.254 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.254 | 0.5936 |
Schistosoma mansoni | thyroid hormone receptor | 0.0059 | 0.3472 | 0.3261 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0059 | 0.3472 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0059 | 0.3472 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0028 | 0.118 | 0.3397 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0313 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0059 | 0.3472 | 0.3261 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0059 | 0.3472 | 0.3261 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3472 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0028 | 0.118 | 0.3397 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0028 | 0.118 | 0.2742 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0059 | 0.3472 | 0.3261 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0059 | 0.3472 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0059 | 0.3472 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.6906 | 0.8837 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0028 | 0.118 | 0.3397 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0059 | 0.3472 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0059 | 0.3472 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0059 | 0.3472 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0028 | 0.118 | 0.0894 |
Schistosoma mansoni | thyroid hormone receptor | 0.0059 | 0.3472 | 0.3261 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0313 | 0.0903 |
Leishmania major | trypanothione reductase | 0.0046 | 0.254 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0313 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0059 | 0.3472 | 1 |
Onchocerca volvulus | 0.0059 | 0.3472 | 1 | |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0016 | 0.0313 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0059 | 0.3472 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0059 | 0.3472 | 0.3261 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0059 | 0.3472 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0059 | 0.3472 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0059 | 0.3472 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0028 | 0.118 | 0.2742 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3472 | 1 |
Brugia malayi | steroid hormone receptor | 0.0059 | 0.3472 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.254 | 0.705 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0059 | 0.3472 | 1 |
Brugia malayi | hypothetical protein | 0.0031 | 0.1425 | 0.4104 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0059 | 0.3472 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0059 | 0.3472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3472 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0059 | 0.3472 | 1 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0313 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.254 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0059 | 0.3472 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.6906 | 0.8837 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.254 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.1425 | 0.4104 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3472 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0028 | 0.118 | 0.3397 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0028 | 0.118 | 0.2742 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0031 | 0.1425 | 0.3519 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3472 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0031 | 0.1425 | 0.1148 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0313 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0059 | 0.3472 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0028 | 0.118 | 0.0894 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0059 | 0.3472 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0028 | 0.118 | 0.2742 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0059 | 0.3472 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0059 | 0.3472 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0028 | 0.118 | 0.2742 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0059 | 0.3472 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0028 | 0.118 | 0.3397 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0016 | 0.0313 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0059 | 0.3472 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0028 | 0.118 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1425 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0059 | 0.3472 | 0.3261 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1425 | 0.1071 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0059 | 0.3472 | 0.3261 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0059 | 0.3472 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0059 | 0.3472 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0028 | 0.118 | 0.2742 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0059 | 0.3472 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0031 | 0.1425 | 0.1071 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.7773 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0059 | 0.3472 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0028 | 0.118 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1425 | 0.1071 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.254 | 0.705 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0059 | 0.3472 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.1425 | 0.4104 |
Brugia malayi | ecdysone receptor | 0.0028 | 0.118 | 0.3397 |
Schistosoma mansoni | zinc finger protein | 0.0028 | 0.118 | 0.0894 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0059 | 0.3472 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0059 | 0.3472 | 0.3261 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0028 | 0.118 | 0.3397 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0028 | 0.118 | 0.0894 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0059 | 0.3472 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0028 | 0.118 | 0.2742 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0016 | 0.0313 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0028 | 0.118 | 0.2742 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0028 | 0.118 | 0.2742 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.254 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.118 | 0.3397 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0059 | 0.3472 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0059 | 0.3472 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0059 | 0.3472 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0059 | 0.3472 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.254 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0028 | 0.118 | 0.3397 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.1425 | 0.1148 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.254 | 0.7316 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0059 | 0.3472 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0028 | 0.118 | 0.0894 |
Brugia malayi | tailless protein | 0.0028 | 0.118 | 0.3397 |
Brugia malayi | hypothetical protein | 0.0031 | 0.1425 | 0.4104 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0059 | 0.3472 | 0.3261 |
Brugia malayi | hypothetical protein | 0.0028 | 0.118 | 0.3397 |
Brugia malayi | nuclear receptor RXR | 0.0028 | 0.118 | 0.3397 |
Brugia malayi | glutathione reductase | 0.0046 | 0.254 | 0.7316 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0028 | 0.118 | 0.0894 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.6906 | 0.8837 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0028 | 0.118 | 0.2742 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0059 | 0.3472 | 0.3261 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0016 | 0.0313 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0031 | 0.1425 | 0.3519 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1425 | 0.1071 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0028 | 0.118 | 0.3397 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.254 | 0.2985 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.254 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.254 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1425 | 0.1071 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0016 | 0.0313 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.0031 | 0.1425 | 0.4104 |
Schistosoma mansoni | nuclear receptor | 0.0028 | 0.118 | 0.0894 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.254 | 0.5936 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0028 | 0.118 | 0.2742 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3472 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.7773 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0028 | 0.118 | 0.2742 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0059 | 0.3472 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0059 | 0.3472 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0028 | 0.118 | 0.3397 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0059 | 0.3472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3472 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0059 | 0.3472 | 0.3261 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 17 % | Inhibition of mushroom tyrosinase at 10 uM | ChEMBL. | 23910596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.