Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | intermediate filament protein | 0.0024 | 0.3759 | 0.3678 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.8644 | 0.7827 |
Loa Loa (eye worm) | intermediate filament protein | 0.0024 | 0.3759 | 0.3759 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.8644 | 0.8626 |
Echinococcus granulosus | lamin | 0.0024 | 0.3759 | 0.3678 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0045 | 1 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.3759 | 0.5 | |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0045 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.8644 | 0.7827 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.004 | 0.8644 | 0.8644 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0045 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0024 | 0.3759 | 0.3759 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0045 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.8644 | 0.7827 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0045 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0045 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.8644 | 0.8626 |
Onchocerca volvulus | 0.0024 | 0.3759 | 0.5 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0045 | 1 | 0.5 |
Echinococcus multilocularis | lamin | 0.0024 | 0.3759 | 0.3678 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.004 | 0.8644 | 0.8572 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.8644 | 0.8626 |
Echinococcus multilocularis | musashi | 0.0024 | 0.3759 | 0.3678 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0045 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0045 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0024 | 0.3759 | 0.3678 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0024 | 0.3759 | 0.343 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.363 | 0.363 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0045 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0045 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.3759 | 0.3759 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0013 | 0.0501 | 0.0501 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0128 | 0.0128 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0045 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0045 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0045 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0045 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0045 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0045 | 1 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0024 | 0.3759 | 0.3678 |
Brugia malayi | intermediate filament protein | 0.0024 | 0.3759 | 0.343 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.8644 | 0.8626 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0045 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.