Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Bloom syndrome, RecQ helicase-like | Starlite/ChEMBL | References |
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bloom syndrome protein | 0.0055 | 0.279 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0037 | 0.1646 | 0.5 |
Echinococcus granulosus | bloom syndrome protein | 0.0055 | 0.279 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0048 | 0.2361 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0043 | 0.2047 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0023 | 0.0715 | 0.0715 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0055 | 0.279 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0055 | 0.279 | 0.279 |
Schistosoma mansoni | DNA helicase recq5 | 0.0023 | 0.0715 | 0.3494 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0715 | 0.4422 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.0000000006015 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0715 | 0.4422 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0055 | 0.279 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0023 | 0.0715 | 0.5 |
Schistosoma mansoni | DNA helicase recq1 | 0.0023 | 0.0715 | 0.3494 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0055 | 0.279 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0037 | 0.1618 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0029 | 0.1144 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0715 | 0.0715 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0029 | 0.1144 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0029 | 0.1144 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0029 | 0.1144 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.8 uM | Inhibition of BLM (unknown origin) by gel-based DNA unwinding assay | ChEMBL. | 24012121 |
IC50 (binding) | = 2.7 uM | Inhibition of WRN (unknown origin) by gel-based DNA unwinding assay | ChEMBL. | 24012121 |
IC50 (binding) | = 3 uM | Inhibition of BLM helicase (unknown origin) binding to DNA | ChEMBL. | 24856061 |
IC50 (binding) | = 5 uM | Inhibition of WRN helicase (unknown origin) | ChEMBL. | 24856061 |
IC50 (binding) | > 50 uM | Inhibition of RECQ1 (unknown origin) by gel-based DNA unwinding assay | ChEMBL. | 24012121 |
IC50 (binding) | = 50 uM | Inhibition of BLM helicase (unknown origin) assessed as branch migration activity | ChEMBL. | 24856061 |
Papp (ADMET) | = 1 ucm/s | Apparent permeability from apical to basolateral side of human Caco2 cells | ChEMBL. | 24012121 |
T1/2 (ADMET) | > 80 min | Half life in mouse liver microsomes in presence of NADPH | ChEMBL. | 24012121 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.