Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4003 | 0.5908 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4003 | 0.5908 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4003 | 0.5908 | 0.5 |
Brugia malayi | thymidylate synthase | 0.1254 | 0.1141 | 0.1141 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4003 | 0.5908 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4003 | 0.5908 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.6362 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1254 | 0.1141 | 0.1141 |
Chlamydia trachomatis | dihydrofolate reductase | 0.6362 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0597 | 0 | 0.5 |
Onchocerca volvulus | 0.1254 | 0.1141 | 0.5 | |
Echinococcus granulosus | dihydrofolate reductase | 0.6362 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.6362 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4003 | 0.5908 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.6362 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.6362 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.6362 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.6362 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.6362 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.12 uM | Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme. | ChEMBL. | 10328306 |
IC50 (binding) | = 0.12 uM | Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme. | ChEMBL. | 10328306 |
IC50 (binding) | = 0.31 uM | Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf9 cells | ChEMBL. | No reference |
IC50 (binding) | = 0.31 uM | Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf9 cells | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Inhibition of human cyclooxygenase-1 (hCOX-1) enzyme. | ChEMBL. | 10328306 |
IC50 (binding) | > 100 uM | Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf9 cells | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Inhibition of human cyclooxygenase-1 (hCOX-1) enzyme. | ChEMBL. | 10328306 |
IC50 (binding) | > 100 uM | Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf9 cells | ChEMBL. | No reference |
Ratio (binding) | > 320 | Relative binding to COX-1 and COX-2 enzymes | ChEMBL. | No reference |
Ratio (binding) | > 320 | Relative binding to COX-1 and COX-2 enzymes | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.