TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 389.473 | Formula: C21H19N5OS
H donors: 2 H acceptors: 2 LogP: 3.18 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1=C(NC(=O)Nc2ccccc2)N(c2ccccc2)C(=S)N2C1CCC2
InChi: 1S/C21H19N5OS/c22-14-17-18-12-7-13-25(18)21(28)26(16-10-5-2-6-11-16)19(17)24-20(27)23-15-8-3-1-4-9-15/h1-6,8-11,18H,7,12-13H2,(H2,23,24,27)
InChiKey: YKNMEICDDDEALI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	serine repeat antigen 5	0.002	0.0204	0.2005
Trypanosoma cruzi	oligopeptidase b	0.0042	0.0478	0.1179
Echinococcus multilocularis	cathepsin L cysteine protease	0.0052	0.0603	0.0603
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0204	0.1407
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0034	0.0386	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0478	0.0723
Leishmania major	cathepsin L-like protease	0.0052	0.0603	0.2497
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0364	0.2769
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0177	0.2186	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0603	0.4794
Onchocerca volvulus		0.0052	0.0603	0.0914
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0022	0.0233	0.0233
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0204	0.0309
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0012	0.0104	0.0157
Trichomonas vaginalis	rotamase, putative	0.0033	0.0364	0.2769
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0718	0.1087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0603	0.4794
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0478	0.1179
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0512	0.0776
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0603	0.4794
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Loa Loa (eye worm)	cathepsin B	0.01	0.1217	0.1844
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0512	0.0776
Trypanosoma cruzi	major cysteine proteinase, putative	0.002	0.0204	0.0375
Schistosoma mansoni	rotamase	0.0033	0.0364	0.0552
Leishmania major	cathepsin L-like protease	0.0052	0.0603	0.2497
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0042	0.0478	0.6853
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0279	0.3481	0.5273
Brugia malayi	hypothetical protein	0.0135	0.1659	0.2514
Plasmodium vivax	serine-repeat antigen (SERA)	0.002	0.0204	0.2005
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.01	0.1217	0.3352
Plasmodium falciparum	serine repeat antigen 2	0.002	0.0204	0.2005
Trypanosoma brucei	oligopeptidase b	0.0042	0.0478	0.1902
Toxoplasma gondii	prolyl endopeptidase	0.0042	0.0478	0.1902
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Mycobacterium ulcerans	aminopeptidase N PepN	0.0034	0.0386	0.4603
Brugia malayi	Cathepsin L-like precursor	0.0052	0.0603	0.0914
Loa Loa (eye worm)	aminopeptidase N	0.0034	0.0386	0.0585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.0386	0.0585
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0204	0.0309
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0046	0.007
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.002	0.0204	0.2005
Leishmania major	cathepsin L-like protease	0.0052	0.0603	0.2497
Echinococcus granulosus	cathepsin l1	0.0052	0.0603	0.0914
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0204	0.0309
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0355	0.1319
Echinococcus granulosus	cathepsin L	0.002	0.0204	0.0309
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0309
Onchocerca volvulus		0.0031	0.0336	0.0509
Entamoeba histolytica	hypothetical protein, conserved	0.0042	0.0478	0.6853
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0355	0.1319
Trypanosoma cruzi	prolyl endopeptidase	0.0042	0.0478	0.1179
Trypanosoma cruzi	major cysteine proteinase, putative	0.002	0.0204	0.0375
Brugia malayi	prolyl oligopeptidase family protein	0.0042	0.0478	0.0723
Echinococcus granulosus	cathepsin b	0.0279	0.3481	0.5273
Echinococcus multilocularis	prolyl endopeptidase	0.0042	0.0478	0.0478
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0046	0.007
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.002	0.0204	0.0309
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.002	0.0204	0.2005
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0718	0.3039
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0157
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.002	0.0204	0.0309
Leishmania major	oligopeptidase b	0.0042	0.0478	0.1902
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Brugia malayi	cathepsin B-like cysteine proteinase	0.0279	0.3481	0.5273
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0336	0.0509
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0042	0.0478	0.1179
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0042	0.0478	0.0723
Onchocerca volvulus		0.0034	0.0386	0.0585
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.002	0.0204	0.2005
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.002	0.0204	0.2005
Trypanosoma cruzi	aminopeptidase, putative	0.0034	0.0386	0.0911
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0012	0.0104	0.0157
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0526	0.6601	0.6601
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0012	0.0104	0.008
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1659	0.2514
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0386	0.0386
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.002	0.0204	0.0604
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.01	0.1217	0.1844
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0233	0.0353
Echinococcus granulosus	acylamino acid releasing enzyme	0.0042	0.0478	0.0723
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0052	0.0603	1
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.001	0.0076	0.5
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.002	0.0204	0.2005
Toxoplasma gondii	aminopeptidase N, putative	0.0012	0.0104	0.013
Brugia malayi	hypothetical protein	0.0012	0.0104	0.0157
Schistosoma mansoni	cathepsin S (C01 family)	0.002	0.0204	0.0309
Loa Loa (eye worm)	fibroinase	0.0052	0.0603	0.0914
Brugia malayi	cathepsin Z-like cysteine proteinase	0.002	0.0204	0.0309
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0012	0.0104	0.0157
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0386	0.0386
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.002	0.0204	0.2005
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0052	0.0603	0.0603
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0718	0.3039
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0052	0.0603	0.0914
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0718	0.1087
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0478	0.3728
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0034	0.0386	0.1469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0204	0.1407
Plasmodium vivax	vivapain-2	0.0052	0.0603	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0052	0.0603	0.0603
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.0386	0.0585
Brugia malayi	TATA binding protein associated factor	0.0012	0.0104	0.0157
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0603	0.4794
Brugia malayi	prolyl oligopeptidase family protein	0.0042	0.0478	0.0723
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0177	0.2186	0.6198
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0022	0.0233	0.046
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0034	0.0386	0.0911
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0512	0.0776
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0177	0.2186	0.3312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0204	0.1407
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0603	0.4794
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0042	0.0478	0.1179
Brugia malayi	prolyl oligopeptidase family protein	0.0042	0.0478	0.0723
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0204	0.1407
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.0386	0.0585
Trypanosoma brucei	cysteine peptidase C (CPC)	0.01	0.1217	0.5407
Echinococcus granulosus	cathepsin l1	0.0052	0.0603	0.0914
Trypanosoma cruzi	cysteine proteinase, putative	0.002	0.0204	0.0375
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0355	0.0818
Trypanosoma brucei	prolyl endopeptidase	0.0042	0.0478	0.1902
Brugia malayi	cathepsin L precursor	0.002	0.0204	0.0309
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0512	0.0512
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0204	0.1407
Trypanosoma cruzi	cysteine peptidase, putative	0.0052	0.0603	0.1548
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0052	0.0603	0.0914
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0204	0.0309
Toxoplasma gondii	cathepsin CPC2	0.002	0.0204	0.0604
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0478	0.7484
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0012	0.0104	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0157
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0042	0.0478	0.6853
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.002	0.0204	0.2005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0012	0.0104	0.013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0052	0.0603	0.4794
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0386	0.0386
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0718	0.1087
Echinococcus multilocularis	cathepsin L	0.002	0.0204	0.0204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Schistosoma mansoni	cpg binding protein	0.0032	0.0358	0.0542
Brugia malayi	Cathepsin L-like precursor	0.0052	0.0603	0.0914
Echinococcus granulosus	cysteine protease	0.002	0.0204	0.0309
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.007	0.007
Trypanosoma brucei	aminopeptidase, putative	0.0012	0.0104	0.013
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0512	0.0776
Plasmodium vivax	unspecified product	0.002	0.0204	0.2005
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0336	0.0509
Loa Loa (eye worm)	prolyl oligopeptidase	0.0526	0.6601	1
Toxoplasma gondii	hypothetical protein	0.0042	0.0478	0.1902
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0052	0.0603	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.002	0.0204	0.0309
Leishmania major	cathepsin L-like protease	0.0052	0.0603	0.2497
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0042	0.0478	0.6853
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0034	0.0386	0.1469
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0046	0.0046
Plasmodium falciparum	serine repeat antigen 3	0.002	0.0204	0.2005
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0204	0.0309
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Plasmodium vivax	vivapain-2	0.0052	0.0603	1
Leishmania major	cathepsin L-like protease	0.0052	0.0603	0.2497
Plasmodium falciparum	serine repeat antigen 7	0.002	0.0204	0.2005
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0603	0.0914
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0034	0.0386	0.1469
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.002	0.0204	0.0309
Brugia malayi	Cathepsin L-like precursor	0.0052	0.0603	0.0914
Echinococcus granulosus	dnaJ subfamily B	0.0434	0.5443	0.8245
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0034	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0603	0.0914
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0204	0.0309
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0204	0.1407
Trypanosoma cruzi	cysteine proteinase, putative	0.002	0.0204	0.0375
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0204	0.0309
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.002	0.0204	0.1407
Plasmodium vivax	serine-repeat antigen (SERA)	0.002	0.0204	0.2005
Entamoeba histolytica	cysteine proteinase, putative	0.0052	0.0603	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0157
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.002	0.0204	0.2005
Echinococcus multilocularis	cathepsin b	0.0279	0.3481	0.3481
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0034	0.0386	0.0585
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.002	0.0204	0.2005
Loa Loa (eye worm)	TATA binding protein associated factor	0.0012	0.0104	0.0157
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.0386	0.0585
Echinococcus multilocularis	expressed protein	0.0033	0.0364	0.0364
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0052	0.0603	0.0914
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0012	0.0104	0.0157
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0204	0.1407
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.002	0.0204	0.2005
Brugia malayi	prolyl oligopeptidase family protein	0.0526	0.6601	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0177	0.2186	0.3312
Plasmodium falciparum	serine repeat antigen 6	0.002	0.0204	0.2005
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0042	0.0478	0.0723
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0034	0.0386	0.0585
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0042	0.0478	0.2701
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0204	0.1407
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0204	0.0309
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0022	0.0233	0.0353
Brugia malayi	Papain family cysteine protease containing protein	0.0052	0.0603	0.0914
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0068	0.0103
Onchocerca volvulus		0.0052	0.0603	0.0914
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0034	0.0386	0.2954
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0042	0.0478	0.1902
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0603	0.0914
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0204	0.0309
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Schistosoma mansoni	hypothetical protein	0.0434	0.5443	0.8245
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0204	0.1407
Plasmodium vivax	vivapain-3	0.002	0.0204	0.2005
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0718	1
Toxoplasma gondii	cathepsin CPL	0.0052	0.0603	0.2497
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0052	0.0603	1
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0012	0.0104	0.013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0309
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0042	0.0478	0.1902
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0718	1
Loa Loa (eye worm)	hypothetical protein	0.0279	0.3481	0.5273
Toxoplasma gondii	cathepsin B	0.01	0.1217	0.5407
Trypanosoma cruzi	cysteine peptidase, putative	0.0052	0.0603	0.1548
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0052	0.0603	0.0914
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0042	0.0478	0.6853
Plasmodium vivax	unspecified product	0.002	0.0204	0.2005
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.007	0.0106
Brugia malayi	cathepsin Z-like cysteine proteinase	0.002	0.0204	0.0309
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0718	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0386	0.0386
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.002	0.0204	0.1407
Brugia malayi	cathepsin L-like precursor	0.0052	0.0603	0.0914
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0042	0.0478	0.0723
Leishmania major	cysteine peptidase A (CPA)	0.0052	0.0603	0.2497
Entamoeba histolytica	aminopeptidase, putative	0.0034	0.0386	0.4568
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Loa Loa (eye worm)	ctsf protein	0.0052	0.0603	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0603	0.0914
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0526	0.6601	1
Giardia lamblia	Cathepsin B precursor	0.01	0.1217	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0042	0.0478	0.5
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.002	0.0204	0.0375
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0046	0.0046
Schistosoma mansoni	cpg binding protein	0.0031	0.0336	0.0509
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0204	0.1407
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0012	0.0104	0.008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0034	0.0386	0.2954
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0364	0.0552
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0718	0.0718
Echinococcus granulosus	expressed protein	0.0033	0.0364	0.0552
Trichomonas vaginalis	rotamase, putative	0.0032	0.0355	0.2686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Leishmania major	cathepsin L-like protease	0.0052	0.0603	0.2497
Entamoeba histolytica	cysteine protease, putative	0.0052	0.0603	1
Echinococcus multilocularis	cathepsin L	0.002	0.0204	0.0204
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0603	0.4794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0603	0.4794
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0526	0.6601	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0279	0.3481	0.5273
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0204	0.0309
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0012	0.0104	0.0558
Plasmodium falciparum	serine repeat antigen 1	0.002	0.0204	0.2005
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0364	0.0552
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0603	0.4794
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0309
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0052	0.0603	0.0914
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0042	0.0478	0.1902
Echinococcus multilocularis	cysteine protease	0.0052	0.0603	0.0603
Brugia malayi	Cathepsin L-like precursor	0.0052	0.0603	0.0914
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.002	0.0204	0.0309
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0204	0.1407
Loa Loa (eye worm)	cysteine protease	0.0052	0.0603	0.0914
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0012	0.0104	0.008
Brugia malayi	prolyl oligopeptidase family protein	0.0177	0.2186	0.3312
Echinococcus multilocularis	cathepsin b	0.0279	0.3481	0.3481
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0042	0.0478	0.2701
Leishmania major	cathepsin L-like protease	0.0052	0.0603	0.2497
Echinococcus granulosus	cathepsin L cysteine protease	0.002	0.0204	0.0309
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0177	0.2186	0.6198
Onchocerca volvulus		0.0052	0.0603	0.0914
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.002	0.0204	0.0309
Toxoplasma gondii	cathepsin CPC1	0.002	0.0204	0.0604
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0177	0.2186	1
Brugia malayi	Peptidase family M1 containing protein	0.0034	0.0386	0.0585
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0279	0.3481	0.5273
Trypanosoma cruzi	cysteine protease, putative	0.002	0.0204	0.0375
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.002	0.0204	0.0309
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0603	0.4794
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0104	0.0157
Loa Loa (eye worm)	prolyl oligopeptidase	0.0042	0.0478	0.0723
Plasmodium falciparum	serine repeat antigen 4	0.002	0.0204	0.2005
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.002	0.0204	0.0309
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0177	0.2186	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0052	0.0603	0.0914
Plasmodium vivax	vivapain-1	0.002	0.0204	0.2005
Schistosoma mansoni	cathepsin C	0.002	0.0204	0.0309
Toxoplasma gondii	preprocathepsin c precursor, putative	0.002	0.0204	0.0604
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0042	0.0478	0.3728
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0204	0.0309
Brugia malayi	hypothetical protein	0.0034	0.0386	0.0585
Brugia malayi	fibroinase precursor	0.002	0.0204	0.0309
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.007	0.0106
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0204	0.0375
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0512	0.0776
Brugia malayi	Cathepsin L-like precursor	0.0052	0.0603	0.0914
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0718	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.01	0.1217	1
Echinococcus multilocularis	cysteine protease	0.0052	0.0603	0.0603
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0012	0.0104	0.0104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0052	0.0603	0.4794
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0603	0.4794
Plasmodium falciparum	serine repeat antigen 9	0.002	0.0204	0.2005
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0042	0.0478	0.6853
Schistosoma mansoni	cathepsin B (C01 family)	0.002	0.0204	0.0309
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0052	0.0603	0.1548
Onchocerca volvulus		0.0052	0.0603	0.0914
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0204	0.1407
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0355	0.0818
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0012	0.0104	0.0157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0204	0.1407
Echinococcus multilocularis	aminopeptidase N	0.0034	0.0386	0.0386
Onchocerca volvulus		0.0012	0.0104	0.0157
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0006	0.0009
Brugia malayi	cathepsin L-like cysteine proteinase	0.002	0.0204	0.0309
Leishmania major	cathepsin L-like protease	0.0052	0.0603	0.2497
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0204	0.0309
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0042	0.0478	0.3728
Onchocerca volvulus		0.0034	0.0386	0.0585
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0309
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0204	0.1407
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.002	0.0204	0.1407
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.002	0.0204	0.0309
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0177	0.2186	0.2186
Plasmodium falciparum	cysteine proteinase falcipain 1	0.002	0.0204	0.2005
Schistosoma mansoni	cpg binding protein	0.0032	0.0358	0.0542
Echinococcus granulosus	cpg binding protein	0.0032	0.0358	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0478	0.0723
Brugia malayi	Peptidase family M1 containing protein	0.0034	0.0386	0.0585
Plasmodium falciparum	serine repeat antigen 8	0.002	0.0204	0.2005
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0042	0.0478	0.1902
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0042	0.0478	0.0478
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0042	0.0478	0.1902
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0042	0.0478	0.609
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0512	0.0512
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0204	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0233	0.0353
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0386	0.0386
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.002	0.0204	0.0604
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0104	0.0157
Trypanosoma cruzi	cysteine peptidase, putative	0.0052	0.0603	0.1548
Brugia malayi	Cathepsin L-like precursor	0.0052	0.0603	0.0914
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.002	0.0204	0.2005
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0042	0.0478	0.0723
Schistosoma mansoni	cathepsin F (C01 family)	0.0052	0.0603	0.0914
Onchocerca volvulus		0.002	0.0204	0.0309
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.01	0.1217	0.5407
Brugia malayi	Cathepsin L-like precursor	0.0052	0.0603	0.0914
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0681	0.2866
Trypanosoma cruzi	oligopeptidase b	0.0042	0.0478	0.1179
Echinococcus granulosus	cathepsin L	0.002	0.0204	0.0309
Entamoeba histolytica	cysteine proteinase, putative	0.0052	0.0603	1
Onchocerca volvulus	Cathepsin L homolog	0.0052	0.0603	0.0914
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.002	0.0204	0.1407
Trypanosoma cruzi	cruzipain precursor, putative	0.0052	0.0603	0.1548
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0478	0.1179
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0512	0.0776
Brugia malayi	Cathepsin L-like precursor	0.0052	0.0603	0.0914
Onchocerca volvulus		0.0052	0.0603	0.0914
Giardia lamblia	Cathepsin B precursor	0.01	0.1217	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0052	0.0603	0.0603
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0046	0.007
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0204	0.0309
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0768	0.1164
Echinococcus granulosus	cathepsin b	0.0279	0.3481	0.5273
Schistosoma mansoni	cathepsin F (C01 family)	0.0052	0.0603	0.0914
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0204	0.1407
Onchocerca volvulus	Cathepsin F homolog	0.0052	0.0603	0.0914
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0309
Echinococcus multilocularis	dnaJ subfamily B	0.0434	0.5443	0.5443
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0012	0.0104	0.008
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0478	0.0723
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.002	0.0204	0.2005
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0104	0.0157
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.002	0.0204	0.2005
Onchocerca volvulus	Cathepsin L homolog	0.0052	0.0603	0.0914
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0204	0.1407
Entamoeba histolytica	cysteine proteinase, putative	0.0052	0.0603	1
Onchocerca volvulus		0.0052	0.0603	0.0914
Onchocerca volvulus		0.0052	0.0603	0.0914
Onchocerca volvulus		0.0052	0.0603	0.0914
Trypanosoma cruzi	cysteine peptidase, putative	0.0052	0.0603	0.1548
Echinococcus granulosus	aminopeptidase N	0.0034	0.0386	0.0585
Echinococcus multilocularis	cpg binding protein	0.0032	0.0358	0.0358
Toxoplasma gondii	aminopeptidase n, putative	0.0012	0.0104	0.013
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0042	0.0478	0.0723
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0052	0.0603	0.2497
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0177	0.2186	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0355	0.3775
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0526	0.6601	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0512	0.0776
Brugia malayi	cathepsin F-like cysteine proteinase	0.002	0.0204	0.0309
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0355	0.1319
Plasmodium falciparum	peptidase, putative	0.0042	0.0478	0.7484
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0279	0.3481	0.5273
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0279	0.3481	1
Trypanosoma cruzi	aminopeptidase, putative	0.0012	0.0104	0.008
Trypanosoma brucei	Aminopeptidase M1, putative	0.0034	0.0386	0.1469
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0233	0.0353
Trypanosoma brucei	Aminopeptidase M1, putative	0.0034	0.0386	0.1469
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0309
Toxoplasma gondii	aminopeptidase N protein	0.0012	0.0104	0.013
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0042	0.0478	0.1902
Echinococcus granulosus	prolyl endopeptidase	0.0042	0.0478	0.0723
Giardia lamblia	Cathepsin B precursor	0.01	0.1217	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 14.2 ug ml-1	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	ChEMBL.	24090920

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24090920

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2436199

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1788589