Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0181 | 0.0092 | 0.0092 |
Schistosoma mansoni | regulator of G protein signaling | 0.0181 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1633 | 0.8902 | 0.8892 |
Echinococcus granulosus | axis inhibition protein axin | 0.0181 | 0.0092 | 0.0103 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0181 | 0.0092 | 0.0103 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0181 | 0.0092 | 0.0103 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0092 | 0.5 |
Echinococcus granulosus | axis inhibition protein axin | 0.0181 | 0.0092 | 0.0103 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1633 | 0.8902 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1633 | 0.8902 | 0.8892 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0185 | 0.0118 | 0.0027 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0181 | 0.0092 | 0.0103 |
Schistosoma mansoni | axis inhibition protein axin | 0.0181 | 0.0092 | 0.0092 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 0.0118 | 0.0118 |
Echinococcus granulosus | expressed protein | 0.0181 | 0.0092 | 0.0103 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0092 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0181 | 0.0092 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1814 | 1 | 1 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1633 | 0.8902 | 1 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0185 | 0.0118 | 0.0133 |
Schistosoma mansoni | regulator of G protein signaling | 0.0181 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1633 | 0.8902 | 0.8892 |
Schistosoma mansoni | regulator of G protein signaling | 0.0181 | 0.0092 | 0.0092 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0181 | 0.0092 | 0.0103 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0181 | 0.0092 | 0.0103 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0181 | 0.0092 | 0.0103 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0181 | 0.0092 | 0.0092 |
Entamoeba histolytica | hypothetical protein | 0.0181 | 0.0092 | 0.5 |
Schistosoma mansoni | axis inhibition protein axin | 0.0181 | 0.0092 | 0.0092 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0185 | 0.0118 | 0.0133 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1814 | 1 | 1 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0181 | 0.0092 | 0.0103 |
Schistosoma mansoni | regulator of G protein signaling | 0.0181 | 0.0092 | 0.0092 |
Schistosoma mansoni | regulator of G protein signaling | 0.0181 | 0.0092 | 0.0092 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0181 | 0.0092 | 0.0103 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0092 | 0.5 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0181 | 0.0092 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0181 | 0.0092 | 0.0103 |
Echinococcus multilocularis | expressed protein | 0.0181 | 0.0092 | 0.0103 |
Entamoeba histolytica | hypothetical protein | 0.0181 | 0.0092 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0092 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0181 | 0.0092 | 0.0092 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 0.0118 | 0.0118 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0181 | 0.0092 | 0.0103 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0181 | 0.0092 | 0.0103 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0181 | 0.0092 | 0.0103 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0092 | 0.5 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0181 | 0.0092 | 0.0103 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0181 | 0.0092 | 0.0092 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0.0092 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0181 | 0.0092 | 0.0103 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0181 | 0.0092 | 0.0103 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 25 % | Inhibition of jack bean urease using urea as substrate assessed as ammonia production at 250 ug/ml after 15 mins relative to control | ChEMBL. | 24095755 |
IZ (functional) | = 6 mm | Antimicrobial activity against Escherichia coli ATCC 25922 | ChEMBL. | 24095755 |
IZ (functional) | = 15 mm | Antimicrobial activity against Candida albicans ATCC 60193 | ChEMBL. | 24095755 |
IZ (functional) | = 30 mm | Antimicrobial activity against Saccharomyces cerevisiae RSKK 251 | ChEMBL. | 24095755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.