Detailed information for compound 1788742

Basic information

Technical information
  • TDR Targets ID: 1788742
  • Name: 4-chloro-N-[4-hydroxy-3-(2H-1,2,4-triazol-3-y lsulfanyl)phenyl]benzenesulfonamide
  • MW: 382.845 | Formula: C14H11ClN4O3S2
  • H donors: 3 H acceptors: 5 LogP: 3.18 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S(=O)(=O)Nc1ccc(c(c1)Sc1ncn[nH]1)O
  • InChi: 1S/C14H11ClN4O3S2/c15-9-1-4-11(5-2-9)24(21,22)19-10-3-6-12(20)13(7-10)23-14-16-8-17-18-14/h1-8,19-20H,(H,16,17,18)
  • InChiKey: RSHGQATUUXQKGC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-N-[4-hydroxy-3-(2H-1,2,4-triazol-3-ylthio)phenyl]benzenesulfonamide
  • ZINC05545049

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.1494 0.1494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Echinococcus granulosus alpha 1A adrenergic receptor 0.0028 0.1494 0.1494
Schistosoma mansoni neuropeptide receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus multilocularis orexin receptor type 2 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Leishmania major DNA polymerase eta, putative 0.0065 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0028 0.1494 0.1494
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0028 0.1494 0.1494
Schistosoma mansoni neuropeptide receptor 0.0028 0.1494 0.1494
Trypanosoma brucei unspecified product 0.0028 0.1423 0.1423
Schistosoma mansoni biogenic amine receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis dna polymerase kappa 0.0041 0.4387 0.4387
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis neuropeptide s receptor 0.0028 0.1494 0.1494
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.4387 0.4387
Giardia lamblia DINP protein human, muc B family 0.0041 0.4387 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0028 0.1494 0.1494
Brugia malayi hypothetical protein 0.0028 0.1494 0.1494
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.4387 1
Schistosoma mansoni neuropeptide receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0028 0.1494 0.5
Echinococcus granulosus dna polymerase eta 0.0065 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0028 0.1494 0.1494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.1494 0.1494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.1494 0.1494
Echinococcus multilocularis g protein coupled receptor 0.0028 0.1494 0.1494
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.1494 0.1494
Brugia malayi putative neuropeptide receptor NPR1 0.0028 0.1494 0.1494
Echinococcus granulosus 7tm_1 domain containing protein 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.4387 0.4387
Onchocerca volvulus 0.0028 0.1494 0.5
Onchocerca volvulus 0.0028 0.1494 0.5
Onchocerca volvulus 0.0028 0.1494 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.1494 0.1494
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.1494 0.1494
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Onchocerca volvulus 0.0028 0.1494 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0028 0.1494 0.1494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Brugia malayi hypothetical protein 0.0028 0.1494 0.1494
Schistosoma mansoni histamine h1 receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Echinococcus multilocularis neuropeptide receptor 0.0028 0.1494 0.1494
Echinococcus granulosus sex peptide receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.1494 0.1494
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis sex peptide receptor 0.0028 0.1494 0.1494
Schistosoma mansoni growth hormone secretagogue receptor 0.0028 0.1494 0.1494
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Schistosoma mansoni amine GPCR 0.0028 0.1494 0.1494
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0028 0.1494 0.1494
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0028 0.1494 0.1494
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.4387 0.4387
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.1494 0.1494
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Schistosoma mansoni DNA polymerase eta 0.0065 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.1494 0.1494
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.1494 0.1494
Schistosoma mansoni amine GPCR 0.0028 0.1494 0.1494
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis neuropeptide receptor A26 0.0028 0.1494 0.1494
Brugia malayi Serotonin receptor 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Schistosoma mansoni amine GPCR 0.0028 0.1494 0.1494
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.1494 0.1494
Brugia malayi sulfakinin receptor protein 0.0028 0.1494 0.1494
Brugia malayi hypothetical protein 0.0028 0.1494 0.1494
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.1494 0.1494
Schistosoma mansoni neuropeptide receptor 0.0028 0.1494 0.1494
Trypanosoma brucei unspecified product 0.0041 0.4387 0.4387
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis neuropeptide FF receptor 2 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus granulosus g protein coupled receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0028 0.1494 0.1494
Brugia malayi RE15519p 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.4387 0.4387
Schistosoma mansoni opsin-like receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Echinococcus multilocularis serotonin receptor 0.0028 0.1494 0.1494
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus multilocularis allatostatin A receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis G protein coupled receptor 139 0.0028 0.1494 0.1494
Schistosoma mansoni hypothetical protein 0.0028 0.1494 0.1494
Brugia malayi Melatonin receptor type 1A 0.0028 0.1494 0.1494
Echinococcus granulosus dna polymerase kappa 0.0041 0.4387 0.4387
Loa Loa (eye worm) hypothetical protein 0.0065 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.4387 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.1423 0.1423
Brugia malayi putative neuropeptide receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis somatostatin receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus granulosus orexin receptor type 2 0.0028 0.1494 0.1494
Echinococcus granulosus G protein coupled receptor 139 0.0028 0.1494 0.1494
Echinococcus multilocularis g-protein coupled receptor 0.0028 0.1494 0.1494
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.3413 0.3413
Brugia malayi AKH receptor 0.0028 0.1494 0.1494
Brugia malayi G-protein coupled receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus granulosus neuropeptide receptor 0.0028 0.1494 0.1494
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.4387 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Echinococcus granulosus somatostatin receptor 0.0028 0.1494 0.1494
Schistosoma mansoni opsin-like receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase eta, putative 0.0065 1 1
Brugia malayi larval opioid receptor 0.0028 0.1494 0.1494
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.1494 0.1494
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.4387 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.1423 0.1423
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Loa Loa (eye worm) melatonin receptor type 1A 0.0028 0.1494 0.1494
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.1494 0.1494
Echinococcus granulosus serotonin receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis fmrfamide receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Brugia malayi hypothetical protein 0.0028 0.1494 0.1494
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.1494 0.1494
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.4387 0.4387
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.1494 0.1494
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis dro:myosuppressin receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.1494 0.1494
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Schistosoma mansoni biogenic amine receptor 0.0028 0.1494 0.1494
Schistosoma mansoni hypothetical protein 0.0028 0.1494 0.1494
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0028 0.1494 0.1494
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Echinococcus granulosus hypothetical protein 0.0028 0.1494 0.1494
Echinococcus granulosus tachykinin peptides receptor 99D 0.0028 0.1494 0.1494
Echinococcus granulosus peptide allatostatin:somatostatin 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Brugia malayi hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.1494 0.1494
Brugia malayi hypothetical protein 0.0028 0.1494 0.1494
Onchocerca volvulus Neuropeptide F receptor homolog 0.0028 0.1494 0.5
Schistosoma mansoni hypothetical protein 0.0028 0.1494 0.1494
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.1494 0.1494
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.1494 0.1494
Echinococcus granulosus neuropeptide receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.1494 0.1494
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.1494 0.1494
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.4387 0.4387
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis g protein coupled receptor 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0028 0.1494 0.1494
Loa Loa (eye worm) TYRA-2 protein 0.0028 0.1494 0.1494
Schistosoma mansoni hypothetical protein 0.0028 0.1494 0.1494
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0028 0.1494 0.1494
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.4387 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.4387 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0028 0.1494 0.1494
Schistosoma mansoni biogenic amine receptor 0.0028 0.1494 0.1494
Schistosoma mansoni alpha-1 adrenergic receptor 0.0028 0.1494 0.1494
Brugia malayi hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Onchocerca volvulus 0.0028 0.1494 0.5
Echinococcus granulosus allatostatin A receptor 0.0028 0.1494 0.1494
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0028 0.1494 0.1494
Brugia malayi Dopamine receptor protein 2 0.0028 0.1494 0.1494
Echinococcus granulosus neuropeptide s receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Brugia malayi neuropeptide F receptor 0.0028 0.1494 0.1494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.1494 0.1494
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Brugia malayi Tachykinin-like peptides receptor 99D 0.0028 0.1494 0.1494
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Onchocerca volvulus 0.0028 0.1494 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.1494 0.1494
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Brugia malayi Dopamine receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0028 0.1494 0.1494
Echinococcus granulosus g protein coupled receptor 0.0028 0.1494 0.1494
Brugia malayi G protein-coupled receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis g protein coupled receptor 0.0028 0.1494 0.1494
Leishmania major DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.1494 0.1494
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.4387 0.4387
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Brugia malayi Serotonin receptor 0.0028 0.1494 0.1494
Schistosoma mansoni neuropeptide f receptor 76f 0.0028 0.1494 0.1494
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Brugia malayi hypothetical protein 0.0028 0.1494 0.1494
Echinococcus multilocularis dna polymerase eta 0.0065 1 1
Brugia malayi G-protein coupled receptor 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.1423 0.1423
Echinococcus granulosus 7TM GPCR rhodopsin 0.0028 0.1494 0.1494
Echinococcus granulosus g protein coupled receptor 0.0028 0.1494 0.1494
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.4387 0.4387
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.4387 0.4387
Schistosoma mansoni opsin-like receptor 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Echinococcus multilocularis neuropeptide receptor 0.0028 0.1494 0.1494
Brugia malayi neuropeptide F receptor 0.0028 0.1494 0.1494
Echinococcus granulosus g-protein coupled receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.1494 0.1494
Echinococcus granulosus fmrfamide receptor 0.0028 0.1494 0.1494
Brugia malayi Dopamine receptor protein 1 0.0028 0.1494 0.1494
Brugia malayi hypothetical protein 0.0028 0.1494 0.1494
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.4387 0.4387
Echinococcus multilocularis fmrfamide receptor 0.0028 0.1494 0.1494
Schistosoma mansoni amine GPCR 0.0028 0.1494 0.1494
Schistosoma mansoni amine GPCR 0.0028 0.1494 0.1494
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.1494 0.1494
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0028 0.1494 0.1494
Schistosoma mansoni myosin xvIII 0.0028 0.1494 0.1494
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0028 0.1494 0.1494
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.4387 0.4387
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0028 0.1494 0.1494
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.4387 1
Leishmania major DNA polymerase eta, putative 0.0037 0.3413 0.3413
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.1494 0.1494
Echinococcus granulosus neuropeptide FF receptor 2 0.0028 0.1494 0.1494
Echinococcus granulosus dro:myosuppressin receptor 0.0028 0.1494 0.1494
Brugia malayi GnHR receptor homolog 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0028 0.1494 0.1494
Trypanosoma brucei unspecified product 0.0028 0.1423 0.1423
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.3413 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Schistosoma mansoni adenoreceptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0028 0.1494 0.1494
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0028 0.1494 0.1494
Echinococcus multilocularis serotonin receptor 0.0028 0.1494 0.1494
Brugia malayi ORL1-like opioid receptor 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494
Onchocerca volvulus 0.0028 0.1494 0.5
Brugia malayi hypothetical protein 0.0028 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0028 0.1494 0.1494

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 13.02 % Inhibition of EGFR (unknown origin) at 10 uM after 30 mins by fluorescence assay relative to control ChEMBL. 24036042
Inhibition (binding) = 56.39 % Inhibition of AKT (unknown origin) at 10 uM after 30 mins by fluorescence assay relative to control ChEMBL. 24036042
Inhibition (binding) = 62.6 % Inhibition of ABL (unknown origin) at 10 uM after 30 mins by fluorescence assay relative to control ChEMBL. 24036042

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.