Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | egl-9 family hypoxia-inducible factor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131326 | All targets in OG5_131326 |
Neospora caninum | 2OG-Fe(II) oxygenase family protein, putative | Get druggable targets OG5_131326 | All targets in OG5_131326 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0058 | 0.0027 | 0.0027 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.051 | 0.8892 | 0.8892 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.051 | 0.8892 | 0.8892 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0 | 0.5 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0058 | 0.0027 | 0.003 |
Entamoeba histolytica | hypothetical protein | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0566 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0058 | 0.0027 | 0.0027 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0056 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0056 | 0 | 0.5 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0058 | 0.0027 | 0.003 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.051 | 0.8892 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0058 | 0.0027 | 0.0027 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.051 | 0.8892 | 0.8892 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.051 | 0.8892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.4881 | 0.4881 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0566 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.6 uM | Inhibition of PHD2 (unknown origin) after 30 mins by fluorescence polarization assay | ChEMBL. | 24042008 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.