Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0369 | 0.9727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0722 | 0.0742 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0378 | 1 | 1 |
Onchocerca volvulus | 0.0026 | 0 | 0.5 | |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0369 | 0.9727 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0035 | 0.0259 | 0.359 |
Trichomonas vaginalis | hypothetical protein | 0.0378 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0369 | 0.9727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.4616 | 0.4746 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0026 | 0 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0038 | 0.034 | 0.0349 |
Loa Loa (eye worm) | glutamate receptor | 0.0042 | 0.045 | 0.0463 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0051 | 0.0722 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0042 | 0.045 | 0.0463 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0047 | 0.0611 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0378 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0378 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0378 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0378 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0378 | 1 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0369 | 0.9727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.9727 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0035 | 0.0259 | 0.359 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0051 | 0.0722 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0378 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0035 | 0.0259 | 0.4239 |
Onchocerca volvulus | 0.0026 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 91.15 uM | Growth inhibition of human HCT15 cells after 48 hrs by SRB assay | ChEMBL. | 24121236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.