Detailed information for compound 1788862

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 244.287 | Formula: C13H9FN2S
  • H donors: 1 H acceptors: 1 LogP: 3.6 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Nc1ccnc2c1scc2
  • InChi: 1S/C13H9FN2S/c14-9-1-3-10(4-2-9)16-12-5-7-15-11-6-8-17-13(11)12/h1-8H,(H,15,16)
  • InChiKey: LANFQVAIPCGZPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0302 0.3843
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Trypanosoma brucei heat shock protein, putative 0.0031 0.0645 0.2543
Trichomonas vaginalis esterase, putative 0.0037 0.0787 0.3103
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3147 0.3147
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0565 0.2227
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0628 0.1996
Trichomonas vaginalis heat shock protein, putative 0.0025 0.048 0.1892
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0112 0.0112
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0787 0.133
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.1739 0.1739
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0112 0.1427
Echinococcus multilocularis tar DNA binding protein 0.0129 0.3147 0.3147
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.2536 1
Giardia lamblia Grp94/Hsp90 0.0025 0.048 0.7443
Loa Loa (eye worm) hypothetical protein 0.0011 0.0112 0.0357
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0112 0.0112
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Plasmodium vivax endoplasmin, putative 0.0031 0.0645 0.8195
Entamoeba histolytica hypothetical protein 0.0074 0.1739 0.6855
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0302 0.0302
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0112 0.0112
Mycobacterium tuberculosis Conserved protein 0.0037 0.0787 0.133
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.048 0.0811
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1187 1
Loa Loa (eye worm) TAR-binding protein 0.0129 0.3147 1
Leishmania major hypothetical protein, conserved 0.0037 0.0787 0.3103
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0565 1
Schistosoma mansoni hypothetical protein 0.0031 0.0628 0.0628
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0053 0.0169
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.2536 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0112 0.1427
Echinococcus granulosus endoplasmin 0.0025 0.048 0.048
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.1739 0.1739
Trichomonas vaginalis heat shock protein, putative 0.0025 0.048 0.1892
Loa Loa (eye worm) hypothetical protein 0.0097 0.2341 0.7439
Schistosoma mansoni heat shock protein 0.0031 0.0645 0.0645
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0167 0.0658
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0012 0.0012
Loa Loa (eye worm) phosphofructokinase 0.0105 0.2536 0.806
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0011 0.0112 0.0357
Brugia malayi steroid hormone receptor 0.0011 0.0112 0.0357
Entamoeba histolytica hypothetical protein 0.0074 0.1739 0.6855
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0112 0.0112
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0167 0.2121
Onchocerca volvulus 0.0037 0.0787 1
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0167 0.0658
Brugia malayi beta-lactamase family protein 0.0037 0.0787 0.2501
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.2341 0.7439
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0167 0.2588
Loa Loa (eye worm) beta-lactamase 0.0037 0.0787 0.2501
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0787 0.133
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0112 0.0357
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0302 0.1192
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3147 0.3147
Echinococcus granulosus heat shock protein 90 0.0025 0.048 0.048
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.2536 1
Echinococcus granulosus heat shock protein 0.0031 0.0645 0.0645
Leishmania major heat shock protein, putative 0.0013 0.0167 0.0658
Treponema pallidum heat shock protein 90 0.0025 0.048 0.1892
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.2536 0.2536
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0787 0.0787
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0112 0.0112
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0787 0.133
Loa Loa (eye worm) hypothetical protein 0.0037 0.0787 0.2501
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0112 0.0112
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0645 0.5432
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0167 0.053
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0565 0.7178
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0645 0.8195
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0787 0.3103
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0167 0.0167
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0645 0.2543
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0112 0.0112
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0645 0.2543
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0787 0.0787
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0112 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0112 0.0357
Loa Loa (eye worm) endoplasmin 0.0031 0.0645 0.2049
Loa Loa (eye worm) hypothetical protein 0.0037 0.0787 0.2501
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0787 0.3103
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0112 0.0112
Brugia malayi Hsp90 protein 0.0013 0.0167 0.053
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Brugia malayi heat shock protein 90 0.0031 0.0645 0.2049
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.2536 1
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0332 0.1308
Echinococcus granulosus tar DNA binding protein 0.0129 0.3147 0.3147
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.2536 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0787 0.3103
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0565 0.8759
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Brugia malayi nuclear hormone receptor 0.0011 0.0112 0.0357
Schistosoma mansoni cpg binding protein 0.0028 0.0549 0.0549
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.3147 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0112 0.0357
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0565 0.8759
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.1739 0.1739
Trypanosoma brucei heat shock protein, putative 0.0031 0.0645 0.2543
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0565 0.2227
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0787 0.3103
Plasmodium falciparum endoplasmin, putative 0.0019 0.0332 0.5145
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.3147 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0549 0.1744
Schistosoma mansoni cpg binding protein 0.0029 0.0589 0.0589
Schistosoma mansoni cpg binding protein 0.0029 0.0589 0.0589
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0112 0.0112
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Loa Loa (eye worm) hypothetical protein 0.0037 0.0787 0.2501
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0628 0.0628
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.5916 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0645 0.2543
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0112 0.0357
Schistosoma mansoni hypothetical protein 0.0031 0.0628 0.0628
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0645 0.2543
Mycobacterium leprae Probable lipase LipE 0.0037 0.0787 0.3103
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0302 0.0961
Echinococcus multilocularis GPCR, family 2 0.0031 0.0628 0.0628
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.048 0.1892
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.2536 0.4287
Loa Loa (eye worm) hypothetical protein 0.0031 0.0628 0.1996
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2536 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0012 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0112 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0112 0.0357
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0787 0.2501
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0787 0.133
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0112 0.0112
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0787 0.0787
Mycobacterium tuberculosis Conserved protein 0.0037 0.0787 0.133
Echinococcus granulosus heat shock protein 90 0.0031 0.0645 0.0645
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0112 0.1427
Plasmodium falciparum heat shock protein 90 0.0031 0.0645 1
Echinococcus granulosus GPCR family 2 0.0031 0.0628 0.0628
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2536 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0112 0.0357
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0012 0.0012
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0167 0.1406
Schistosoma mansoni endoplasmin 0.0031 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0011 0.0112 0.0357
Schistosoma mansoni hypothetical protein 0.0031 0.0628 0.0628
Echinococcus multilocularis heat shock protein 90 0.0031 0.0645 0.0645
Onchocerca volvulus 0.0037 0.0787 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0787 0.2501
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0112 0.0112
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0112 0.0112
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0332 0.1308
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0112 0.0357
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0565 0.2227
Brugia malayi 6-phosphofructokinase 0.0105 0.2536 0.806
Plasmodium vivax heat shock protein, putative 0.0013 0.0167 0.2121
Echinococcus granulosus cpg binding protein 0.0029 0.0589 0.0589
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0645 0.2049
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0645 0.2543
Brugia malayi phosphofructokinase 0.0105 0.2536 0.806
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0112 0.0112
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0645 0.2543
Brugia malayi CXXC zinc finger family protein 0.0028 0.0549 0.1744
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0112 0.0357
Brugia malayi beta-lactamase family protein 0.0037 0.0787 0.2501
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0302 0.0961
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0112 0.0112
Trypanosoma brucei heat shock protein, putative 0.0031 0.0645 0.2543
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0645 0.2543
Schistosoma mansoni hypothetical protein 0.0395 1 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0167 0.1406
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0565 0.4758
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0302 0.1192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0112 0.0357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0112 0.0357
Toxoplasma gondii exonuclease III APE 0.0018 0.0302 0.2547
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.2536 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0628 0.0628
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.2536 0.2536
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0787 0.3103
Echinococcus multilocularis heat shock protein 0.0031 0.0645 0.0645
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0565 0.2227
Brugia malayi 6-phosphofructokinase 0.0105 0.2536 0.806
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0112 0.0112
Echinococcus multilocularis endoplasmin 0.0025 0.048 0.048
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0302 0.1192
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0056 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0112 0.0112
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0565 0.4758
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0565 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0787 0.3103
Brugia malayi hypothetical protein 0.0074 0.1739 0.5525
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.2536 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0302 0.6301
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0787 0.3103
Loa Loa (eye worm) hypothetical protein 0.0011 0.0112 0.0357
Schistosoma mansoni hypothetical protein 0.0067 0.1548 0.1548
Echinococcus multilocularis dnaJ subfamily B 0.0395 1 1
Mycobacterium ulcerans heat shock protein 90 0.0025 0.048 0.1892
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.048 0.1892
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0787 0.133
Brugia malayi beta-lactamase 0.0037 0.0787 0.2501
Trypanosoma brucei heat shock protein, putative 0.0031 0.0645 0.2543
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0112 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2536 1
Trypanosoma brucei heat shock protein, putative 0.0031 0.0645 0.2543
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0565 0.7178
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3147 0.3147
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0112 0.0112
Toxoplasma gondii ABC1 family protein 0.0037 0.0787 0.6628
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.2536 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0112 0.0357
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0112 0.0357
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0056 0.0056
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.2536 0.806
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0302 0.1192
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0112 0.0357
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0302 0.1192
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0167 0.2121
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0112 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0112 0.0357
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.048 0.7443
Loa Loa (eye worm) hypothetical protein 0.0011 0.0112 0.0357
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3147 0.3147
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0787 0.2501
Brugia malayi nuclear receptor NHR-88 0.0011 0.0112 0.0357
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0565 0.4758
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0112 0.0112
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0565 0.2227
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0112 0.0357
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0112 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0565 0.2227
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0313 0.1234
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.2341 0.7439
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0787 0.3103
Mycobacterium ulcerans beta-lactamase 0.0037 0.0787 0.3103
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0787 0.3103
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0302 0.469
Schistosoma mansoni ap endonuclease 0.0018 0.0302 0.0302
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0112 0.0112
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0112 0.0112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.2341 0.7439
Loa Loa (eye worm) RNA binding protein 0.0129 0.3147 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0112 0.0112
Mycobacterium ulcerans lipase LipD 0.0037 0.0787 0.3103
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0628 0.1996
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0628 0.1996
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1548 0.492
Entamoeba histolytica hypothetical protein 0.0074 0.1739 0.6855
Loa Loa (eye worm) hypothetical protein 0.0037 0.0787 0.2501
Echinococcus multilocularis heat shock protein 90 0.0025 0.048 0.048
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0645 0.2543
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.048 0.1892
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0787 0.3103
Loa Loa (eye worm) hypothetical protein 0.0011 0.0112 0.0357
Trypanosoma brucei heat shock protein, putative 0.0031 0.0645 0.2543
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0167 0.0658
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0645 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0787 0.133
Onchocerca volvulus 0.0011 0.0112 0.1427
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0012 0.0012
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0167 0.0167
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0112 0.0112
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0167 0.2588
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0645 0.2543
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0565 0.8759
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0565 0.2227
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.2536 1
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0565 0.2227
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.2536 0.806
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0112 0.0357
Onchocerca volvulus 0.0037 0.0787 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0302 0.1192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0112 0.0357
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Schistosoma mansoni hypothetical protein 0.0074 0.1739 0.1739
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.048 0.048
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0167 0.0658
Mycobacterium tuberculosis Conserved protein 0.0037 0.0787 0.133
Trypanosoma brucei RNA helicase, putative 0.0102 0.2457 0.9689
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0645 0.2543
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0112 0.0112
Brugia malayi RNA binding protein 0.0129 0.3147 1
Schistosoma mansoni coup transcription factor 0.0011 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0067 0.1548 0.492
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0787 0.3103
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0787 0.0787
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0112 0.0112
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0302 0.469
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Trichomonas vaginalis heat shock protein, putative 0.0025 0.048 0.1892
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0565 0.2227
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0645 0.5432
Schistosoma mansoni hypothetical protein 0.0102 0.2457 0.2457
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3147 0.3147
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.2536 0.2536
Brugia malayi TAR-binding protein 0.0129 0.3147 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.048 0.1892
Loa Loa (eye worm) hypothetical protein 0.0011 0.0112 0.0357
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1349 0.1349
Schistosoma mansoni heat shock protein 0.0013 0.0167 0.0167
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0628 0.0628
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0302 0.1192
Brugia malayi ecdysteroid receptor 0.0011 0.0112 0.0357
Brugia malayi Endoplasmin precursor 0.0031 0.0645 0.2049
Schistosoma mansoni endoplasmin 0.0031 0.0645 0.0645
Onchocerca volvulus 0.0028 0.0549 0.6974
Trypanosoma brucei heat shock protein, putative 0.0031 0.0645 0.2543
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0302 0.1192
Trypanosoma brucei heat shock protein, putative 0.0031 0.0645 0.2543
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0787 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.048 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0787 0.133
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0787 0.3103
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0112 0.0357
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0056 0.0178
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0112 0.0112
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0302 0.1192
Loa Loa (eye worm) hypothetical protein 0.0037 0.0787 0.2501
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0112 0.0357
Loa Loa (eye worm) hypothetical protein 0.0011 0.0112 0.0357
Schistosoma mansoni heat shock protein 0.0031 0.0645 0.0645
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0302 0.0302
Entamoeba histolytica hypothetical protein 0.0074 0.1739 0.6855
Schistosoma mansoni hypothetical protein 0.0031 0.0628 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0112 0.0357
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0112 0.0357
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0645 0.2543
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2536 1
Schistosoma mansoni ap endonuclease 0.0018 0.0302 0.0302
Echinococcus multilocularis cpg binding protein 0.0029 0.0589 0.0589
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.2536 0.2536
Leishmania major heat shock protein 83-1 0.0031 0.0645 0.2543
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0112 0.0357
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0302 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0112 0.0357
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0112 0.0112

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 91.16 uM Growth inhibition of human HCT15 cells after 48 hrs by SRB assay ChEMBL. 24121236

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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